Clinical, microbiological, immunological and metabolic features of purulent process occurrence in the periodontium in patients with chronic generalized periodontitis.
Keywords:generalized periodontitis, lipid peroxidation, immunodeficiency, biocenosis
Significance of processes of freelipid peroxidation, local immunological disorders and features of biocenosis of periodontal tissues and their role in the occurrence of purulent process in the periodontium in 64 patients with chronic generalized periodontitis of I-II severity degree is proved. By total of results of clinical, microbiological and metabolic studies in patients it was showed, that formation of purulent process in periodontal tissues is due to the dominance in the gingival econiche of staphylococus, fuzospiliar infection, deficiency of secretory immunity of the oral mucosa, intensity of lipid peroxidation and inhibition of antioxidant protection. It was found that the normalization of the levels of immunoglobulins, especially of sIgA, cytokines (IL-1β, TNF-α), the operation of POL and AOP are the main markers of improved clinical picture of the disease.
Grudyanov AI. [Periodontal diseases]. Moscow: Publishing House "Medical Information Agency". 2009;336. Russian.
Mashchenko IS. [Periodontal disease]. Dnepro-petrovsk: Colo. 2003;271. Russian.
Muller HP. [Periodontics]. L'vov. GalDent. 2004;256. Russian.
Cochran D.L. Inflammation and bone loss in pe-riodontal disease. Periodontol. 2008;79:1569-76.
Delves PJ, Roitt IM. The immune system. Second of two parts. J Med. 2000;343:108-17.
Kebschull M, Papapanou PN. Periodontal micro-bial complexes associated with specific cell and tissue responses. J Clin Periodontol. 2011;38:17-27.
Michael PM. Immunological and Inflammatory Aspects of Periodontal Disease. Continuing Education Course. 2013;1-18.
Socransky SS, Haffajee AD. Periodontal micro-bial ecology. Periodontol 2005;38:135-187.
How to Cite
Copyright (c) 2017 Medical Perspectives
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Submitting manuscript to the journal "Medicni perspektivi" the author(s) agree with transferring copyright from the author(s) to publisher (including photos, figures, tables, etc.) editor, reproducing materials of the manuscript in the journal, Internet, translation into other languages, export and import of the issue with the author’s article, spreading without limitation of their period of validity both on the territory of Ukraine and other countries. This and other mutual duties of the author and all co-authors separately and editorial board are secured by written agreement by special form to use the article, the sample of which is presented on the site.
Author signs a written agreement and sends it to Editorial Board simultaneously with submission of the manuscript.