Application of cytogenetic researches in efficiency assessment of vaccines against leukemia virus in cattle

Maria Drahulian, Tetiana Dorosch, Svitlana Kostenko

Аннотация


We studied the effect of immunogens of the leukemia virus in cattle on the cytogenetic parameters of bone marrow in the dynamics of immunogenesis. We found that each drug has its own specific effect, which is due to the structural differences of the leukemia virus in cattle. The method of cytogenetic studies of bone marrow cells should be used to assess the safety and immunogenic properties of retroviral origin drugs


Ключевые слова


genetic monitoring; cattle leukemia virus; immunogenesis; mice; bone marrow cells

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Литература


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Il’inskykh, N. N. (1984). Tsitogenenticheskiy analіz posledstviy infektsionnogo mutageneza v svyati s sostoyaniyem immunoreaktivnosti organizma [Cytogenetic analysis of consequences of infectious mutagenesis complimented by condition of immunoreactivity of an organism]. Tomsk, 42.

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Yarylin, А. А. (1996). Apoptoz i ego mesto v immunnykh protsessakh [Apoptosis and its role in immune processes]. Immunology, 6, 10–23.

Shimizu, N., Kamezaki, F., Shigematsu, Sh. (2005). Tracking of microinjected DNA in live cells reveals the intracellular behavior and elimination of extrachromosomal genetic material. Nucleic Acids Research, 33 (19), 6296–6307. doi: 10.1093/nar/gki946


Пристатейная библиография ГОСТ


Cell proliferation blocking and mitosis pathology in cells infected by cytomegalovirus / N. E. Fedorova et. al. // Academy of science abstracts. 2003. Vol. 392, Issue 4. P. 552–555.

Cerkhezia S. E., Mykhaylova G. R., Gorshunova L. P. Chromosome research of bone marrow cells of mice which took anti rabies vaccine // Cytology and genetics. 1980. Vol. 14, Issue 4. P. 67–70.

Infectious caryopathology / I. N. Ilinskykh et. al. // Tomsk: Tomsk university press. 2005. 168 p.

Yarylin А. А. Apoptosis and its role in an organism as a whole // Glaucoma. 2003. Vol. 2. P. 46–54.

Serenot Ch. K. Studies related to morphological changes k-562 cell culture nuclei influenced by viral vaccine // Thesis collection related to the topics of 64-th International scientific students’ conference named after N. I. Pirogov. 2005. P. 52.

Sivakova T. N., Mylnikova E. A. Caryopathic effect of Nobivak Rabies vaccine on bone marrow cells and white mice testis // Fundamental medical-biological science and practical healthcare. 2010. P. 46–49.

Methodological guidance on cytogenetic testing in swine breeding / A. F. Yakovlev et. al. Kharkiv: Ukraine Veterinary Theoretical research institute. 1990. 24 p.

Interleukin-4 inhibits tumor necrosis factor-α–induced and spontaneous apoptosis of biomaterial-adherent macrophages / Brodbeck W. G. et. al. // Journal of Laboratory and Clinical Medicine. 2002. Vol. 139, Issue 2. P. 90–100. doi: 10.1067/mlc.2002.121260

Spontanous ex vivo apoptosis of peripheral blood mononuclear cells in patients with head and neck cancer / T. Saito et. al. // Clinical Cancer Research. 1999. Vol. 5. Р. 1263–1273.

Il’inskykh N. N. Cytogenetic analysis of consequences of infectious mutagenesis complimented by condition of immunoreactivity of an organism: abstract PhD thesis. Tomsk, 1984. 42 p.

Ingel F. I. Perspectives of micronuclear test in human lymphocytes cultivated in cytogenetic block conditions. Part 1: Cell proliferation // Ecological Genetics. 2006. Vol. 4, Issue 3. P. 7–19. doi: 10.17816/ecogen437-19

Ilin D. A. Formation of micronuclei // Natural science and humanism. 2006. Vol. 3. P. 58.

Yarylin А. А. Apoptosis and its role in immune processes // Immunology. 1996. Vol. 6. P. 10–23.

Shimizu N., Kamezaki F., Shigematsu Sh. Tracking of microinjected DNA in live cells reveals the intracellular behavior and elimination of extrachromosomal genetic material. Nucleic Acids Research. 2005. Vol. 33, Issue 19. P. 6296–6307. doi: 10.1093/nar/gki946





DOI: https://doi.org/10.15587/2313-8416.2018.121096

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ISSN 2313-8416 (Online), ISSN 2313-6286 (Print)