Peculiarities of protein metabolism in pregnancy complicated by intrauterine infection
DOI:
https://doi.org/10.15587/2519-4798.2018.121784Keywords:
intrauterine infections, protein metabolism, implementation of intrauterine infectionAbstract
Purpose of the study. To determine the features of protein metabolism by changes in proteinograms in pregnant women with intrauterine infection.
Materials and methods. The examined 180 pregnant women were divided into 3 groups depending on the presence and nature of the infection: viral (CMV, herpes simplex virus types 1, 2, 6), bacterial (chlamydia, ureaplasma, mycoplasma) and mixed (viral-bacterial) infection. Each of these groups was divided into 2 subgroups: with subsequent implementation of infection in newborns (1) and without it (0). This group in the study was the main one. Control group included 50 patients with physiological pregnancy.
Serum of pregnant women was assessed for the content of total protein and protein fractions: albumin, total globulin fraction, alpha-1, alpha-2, beta and gamma globulin fractions.
Results. The study showed that protein composition of blood is most affected by viral infections. An increase in the level of gamma globulins is the most noticeable change in this case. However, patients with implementation of viral infection barely had a tendency to an increase in this fraction, while in the subgroup without implementation of this infection this increase was significant and quite expressed (by 30 %, p<00.05).
This increase in immunoglobulins, along with other conditions, will likely prevent further implementation of viral infection in newborns.
The presence of bacterial infection in the examined pregnant was also shown to have a weaker impact on protein metabolism. As a feature, we can note only slight hyperproteinemia (not more than 10 % higher than in control) in patients with implementation of bacterial infection, which was not observed in any of the other groups. This increase in the level of total protein could have developed due to the impact of infection on the genitourinary system and a disruption of excretion of nitrogenous compounds.
Combined viral and bacterial infections resulted in a more pronounced effect of the viral infection, although this group was found to have certain features in the form of moderate dysproteinemia with a decrease in albumin level and an increase in alpha and beta globulin fractions.
Conclusions. This study showed that intrauterine infection in pregnant women can affect protein composition of blood serum. The peculiarities of the impact of different types of infectious agents are variously reflected in their action on various aspects of protein metabolism in pregnant womenReferences
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Copyright (c) 2018 Mikola Shcherbina, Liudmyla Vygivska
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