Hyponatremia in patients with chronic heart failure and preserved ejection fraction of the left ventricle

Authors

  • Ekaterina Lazidi SI "L. T. Malaya National Institute of Therapy of National Academy of Medical Sciences of Ukraine" L. Maloi ave., 2a, Kharkiv, Ukraine, 61039, Ukraine https://orcid.org/0000-0001-6263-5667
  • Iurii Rudyk SI "L. T. Malaya National Institute of Therapy of National Academy of Medical Sciences of Ukraine" L. Maloi ave., 2a, Kharkiv, Ukraine, 61039, Ukraine
  • Olena Visotska Kharkiv National University of Radio Electronics Nauky ave., 14, Kharkiv, Ukraine, 61166, Ukraine https://orcid.org/0000-0003-3723-9771
  • Anna Pecherska Kharkiv National University of Radio Electronics Nauky ave., 14, Kharkiv, Ukraine, 61166, Ukraine https://orcid.org/0000-0001-7069-0674
  • Ganna Bolotskykh SI "L. T. Malaya National Institute of Therapy of National Academy of Medical Sciences of Ukraine" L. Maloi ave., 2a, Kharkiv, Ukraine, 61039, Ukraine

DOI:

https://doi.org/10.15587/2519-4798.2018.122201

Keywords:

chronic heart failure, preserved ejection fraction, hyponatremia, clinical and prognostic value

Abstract

Aim of the study: to study the occurrence of hyponatremia in patients with chronic heart failure (CHF) with LVPEF.

Material and methods: The study multi-directionally included 361 patients with CHF and LVPEF, who were at stationary treatment in the clinic SI “National institute of therapy, named after L.T. Malaya, NAMS of Ukraine”. All patients were divided in 3 groups: Group 1 – 120 patients with the stable course of the disease. Group 2 –163 patients with decompensation of CHF in LVPEF. Group 3 included 78 patients with HF and LVPEF, died as a result of HF acute decompensation. The obtained results were processed using the package of applied statistic programs SPSS 17.0.

Results of the study: In group 1 6 patients (5.0 %) demonstrated hyponatremia. In group 2 it was detected in 42 patients (25.8 %), in 3 group – in 30 persons (38.0 %). Hyponatremia occurs more often in patients with CHF and LVPEF older than 60 years (75.6±4.9 %) comparing with younger patients (24.4±4.9 %, p<0,04). It was also established, that among patients with hyponarema there were more men (65.0±4.8 %), than women (35.0±4.8 %, p<0,01). The obtained data testify that hyponatremia in patients with the stable course of HF and LVPEF is associated with lower mean values of the aldosterone concentration and higher potassium levels in blood serum. NTproBNP content as other biochemical parameters in the compared groups of patients with stable HF and LVPEF didn’t differ.

Conclusions: Thus, the obtained data allow to make the following conclusions:

1. Hyponatremia in patients with the stable course of HF and LVPEF is associated with lower mean values of the aldosterone concentration and higher potassium levels in blood serum. NTproBNP concentration patients with CHF and LVPEF with different hyponatremia levels didn’t differ.

2. Among patients with CHF and LVPEF hyponatremia occurs more often in older male patients.

3. Hyponatemia at CHF and LVPEF is associated with the more severe clinical course and unfavorable outcome of the disease

Author Biographies

Ekaterina Lazidi, SI "L. T. Malaya National Institute of Therapy of National Academy of Medical Sciences of Ukraine" L. Maloi ave., 2a, Kharkiv, Ukraine, 61039

Postgraduate student

Department of Clinical Pharmacology and Pharmacogenetics of Noncommunicable Diseases

Iurii Rudyk, SI "L. T. Malaya National Institute of Therapy of National Academy of Medical Sciences of Ukraine" L. Maloi ave., 2a, Kharkiv, Ukraine, 61039

MD, Head of Department

Department of Clinical Pharmacology and Pharmacogenetics of Noncommunicable Diseases

Olena Visotska, Kharkiv National University of Radio Electronics Nauky ave., 14, Kharkiv, Ukraine, 61166

Doctor of Technical Sciences, Professor

Department of Biomedical Engineering

Anna Pecherska, Kharkiv National University of Radio Electronics Nauky ave., 14, Kharkiv, Ukraine, 61166

PhD

Department of Biomedical Engineering

Ganna Bolotskykh, SI "L. T. Malaya National Institute of Therapy of National Academy of Medical Sciences of Ukraine" L. Maloi ave., 2a, Kharkiv, Ukraine, 61039

Junior Researcher

Department of Clinical Pharmacology and Pharmacogenetic of Noncommunicable Diseases

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Published

2018-03-01

How to Cite

Lazidi, E., Rudyk, I., Visotska, O., Pecherska, A., & Bolotskykh, G. (2018). Hyponatremia in patients with chronic heart failure and preserved ejection fraction of the left ventricle. ScienceRise: Medical Science, (2 (22), 4–9. https://doi.org/10.15587/2519-4798.2018.122201

Issue

No. 2 (22) (2018)

Section

Medical Science

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Copyright (c) 2018 Ekaterina Lazidi, Iurii Rudyk, Iurii Rudyk, Olena Visotska, Olena Visotska, Anna Pecherska, Anna Pecherska

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