Dynamics of cadmium acclumulation in the internal organs of rats after exposure to cadmium chloride and cadmium sulphide nanopartiles of various sizes.

Authors

  • O. L. Apykhtina
  • K. P. Kozlov

DOI:

https://doi.org/10.26641/2307-0404.2017.2.109707

Keywords:

nanoparticles, cadmium, toxicity, content in internal organs

Abstract

The article presents the results of study of cadmium accumulation in the internal organs of Wistar rats after prolonged intraperitoneal administration of cadmium chloride and cadmium sulphide nanoparticles of 4-6 nm and 9-11 nm in size in a dose of 0.08 mg /kg/day calculated as cadmium. Toxic effects were evaluated after 30 injections (1.5 months), 60 injections (3 months), and 1.5 months after the exposure has been ceased. The results of the study showed that the most intensive accumulation of cadmium was observed in the kidneys and liver of experimental animals, which is due to the peculiarities of the toxicokinetics and the route of administration of cadmium compounds. In the kidneys, spleen and thymus of animals exposed to cadmium sulphide nanoparticles, a greater concentration of cadmium than in the organs of animals exposed to cadmium chloride was found. Cadmium accumulated more intensively in the spleen after exposure to larger nanoparticles, than in the kidneys and thymus. In the liver, heart, aorta and brain significant accumulation was observed after cadmium chloride exposure.

 

Author Biographies

O. L. Apykhtina

SI «Institute for Occupational Health of AMS of Ukraine»
laboratory of industrial toxicology and occupational hygiene when using chemicals
Saksaganskogo str., 75, Kyiv, Ukraine

K. P. Kozlov

SI «Institute for Occupational Health of AMS of Ukraine»
laboratory of industrial toxicology and occupational hygiene when using chemicals
Saksaganskogo str., 75, Kyiv, Ukraine

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Published

2017-07-29

How to Cite

1.
Apykhtina OL, Kozlov KP. Dynamics of cadmium acclumulation in the internal organs of rats after exposure to cadmium chloride and cadmium sulphide nanopartiles of various sizes. Med. perspekt. [Internet]. 2017Jul.29 [cited 2024Nov.21];22(2):4-9. Available from: https://journals.uran.ua/index.php/2307-0404/article/view/109707

Issue

Vol. 22 No. 2 (2017)

Section

THEORETICAL MEDICINE

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