HLA DRB1 polymorphism and risk of HIV/tuberculosis co-infection.

Authors

  • L. R. Shostakovych-Koretskaya
  • O. O. Volikova
  • K. Y. Lytvyn
  • I. O. Gubar
  • O. A. Kushnerova
  • O. V. Sheveleva

DOI:

https://doi.org/10.26641/2307-0404.2017.3.111930

Keywords:

HLA DRB1 gene polymorphism, HIV-infected patients, co-infection HIV/tuberculosis

Abstract

In the research data on the study of interconnection between polymorphism of HLA DRB1 genes and the risk of HIV infection and co-infection and HIV/tuberculosis are presented.The cohort of observation was HIV-infected individuals with different clinical stages aged from 24 to 58 years, average age being 38 years. 90 patients (89.2%) received HAART.There were 32 (31.4%) HIV-infected patients with manifestations of tuberculosis, 70 (68.6%) HIV patients without manifestations of tu­ber­culosis. Among the cohort of HIV-infected patients with manifestations of tuberculosis, pulmonary forms of tuberculosis was in 32 (100%), of which extrapulmonary forms of tuberculosis were in 12 (37.5%) patients. The majority of cases of tuberculosis occurred in HIV-infected patients in the IV clinical stage. Among HIV-infected patients, the following alleles of the HLA gene DRB1 *01 (10%) *04 (10%) *07 (13%), *11 (15%), *13 (13%), *15 (10%) occurred more often, HLA DRB1 *03 *08 *09 *10, *12, *14, *16, * 17, *18 were rarely found (1-7%). Similar distributions of DRB1 genes were noted among residents of the region with the dominance of HLA DRB1 *01 *04 *07 *11 *13 and *15. With the presence of alleles of the locus DRB1 *13, DRB1 *03 and DRB1 *08, the greatest probability of co-infection of tuberculosis was observed in HIV-infected patients. The risk of tuberculosis is by 2 times higher with a significant difference in HIV-infected patients with DRB1 *13 locus alleles, DRB1 *03 – by 4.4 times and DRB1 *08 – by 5.4 times. Significant chances of tuberculosis occurrence are higher – by 2.6 times in HIV-infected patients with DRB1 *13 locus alleles, DRB1 *03 – by 5.1 times and DRB1 *08 – by 6.4 times. Thus, the variability of the HLA DRB1 locus alleles may play a predisposing or protective role in the occurrence of tuberculosis in HIV-infected patients.

Author Biographies

L. R. Shostakovych-Koretskaya

SE «Dnipropetrovsk medical academy of Health Ministry of Ukraine»
Department of Infectious Diseases
V. Vernadsky str., 9, Dnipro, 49044, Ukraine

O. O. Volikova

SE «Dnipropetrovsk medical academy of Health Ministry of Ukraine»
Department of Infectious Diseases
V. Vernadsky str., 9, Dnipro, 49044, Ukraine

K. Y. Lytvyn

SE «Dnipropetrovsk medical academy of Health Ministry of Ukraine»
Department of Infectious Diseases
V. Vernadsky str., 9, Dnipro, 49044, Ukraine

I. O. Gubar

SE «Dnipropetrovsk medical academy of Health Ministry of Ukraine»
Department of Infectious Diseases
V. Vernadsky str., 9, Dnipro, 49044, Ukraine

O. A. Kushnerova

SE «Dnipropetrovsk medical academy of Health Ministry of Ukraine»
Department of Infectious Diseases
V. Vernadsky str., 9, Dnipro, 49044, Ukraine

O. V. Sheveleva

SE «Dnipropetrovsk medical academy of Health Ministry of Ukraine»
Department of Infectious Diseases
V. Vernadsky str., 9, Dnipro, 49044, Ukraine

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1.
Shostakovych-Koretskaya LR, Volikova OO, Lytvyn KY, Gubar IO, Kushnerova OA, Sheveleva OV. HLA DRB1 polymorphism and risk of HIV/tuberculosis co-infection. Med. perspekt. [Internet]. 2017Oct.12 [cited 2024Nov.5];22(3):81-8. Available from: https://journals.uran.ua/index.php/2307-0404/article/view/111930

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CLINICAL MEDICINE