HLA DRB1 polymorphism and risk of HIV/tuberculosis co-infection.
DOI:
https://doi.org/10.26641/2307-0404.2017.3.111930Ключові слова:
HLA DRB1 gene polymorphism, HIV-infected patients, co-infection HIV/tuberculosisАнотація
In the research data on the study of interconnection between polymorphism of HLA DRB1 genes and the risk of HIV infection and co-infection and HIV/tuberculosis are presented.The cohort of observation was HIV-infected individuals with different clinical stages aged from 24 to 58 years, average age being 38 years. 90 patients (89.2%) received HAART.There were 32 (31.4%) HIV-infected patients with manifestations of tuberculosis, 70 (68.6%) HIV patients without manifestations of tuberculosis. Among the cohort of HIV-infected patients with manifestations of tuberculosis, pulmonary forms of tuberculosis was in 32 (100%), of which extrapulmonary forms of tuberculosis were in 12 (37.5%) patients. The majority of cases of tuberculosis occurred in HIV-infected patients in the IV clinical stage. Among HIV-infected patients, the following alleles of the HLA gene DRB1 *01 (10%) *04 (10%) *07 (13%), *11 (15%), *13 (13%), *15 (10%) occurred more often, HLA DRB1 *03 *08 *09 *10, *12, *14, *16, * 17, *18 were rarely found (1-7%). Similar distributions of DRB1 genes were noted among residents of the region with the dominance of HLA DRB1 *01 *04 *07 *11 *13 and *15. With the presence of alleles of the locus DRB1 *13, DRB1 *03 and DRB1 *08, the greatest probability of co-infection of tuberculosis was observed in HIV-infected patients. The risk of tuberculosis is by 2 times higher with a significant difference in HIV-infected patients with DRB1 *13 locus alleles, DRB1 *03 – by 4.4 times and DRB1 *08 – by 5.4 times. Significant chances of tuberculosis occurrence are higher – by 2.6 times in HIV-infected patients with DRB1 *13 locus alleles, DRB1 *03 – by 5.1 times and DRB1 *08 – by 6.4 times. Thus, the variability of the HLA DRB1 locus alleles may play a predisposing or protective role in the occurrence of tuberculosis in HIV-infected patients.
Посилання
Bondarenko VN, Ruzanov DJu. [HIV-associated tuberculosis (literature review)]. Problemy zdorov'ja i jekologii. 2008;3(17):41-46. Russian.
Volikova OA, Shostakovych-Koretskaya LR, Lytvyn EY, Kushnerova EA, Petul'ko AP, Panikova TN, Vaganova ON. [The emergence of HIV-associated tuberculosis, depending on the system HLA]. Scientific and Practical Conference. Profilaktychna medycyna. 2015;3/4(25):18-19. Russian.
Volikova OA, Shostakovych-Koretskaya LR, Lytvyn EY, Kushnerova EA, Petul'ko AP, Panikova TN. [Change of immunological and virological parameters in HIV depending on the histocompatibility system]. Scientific and Practical Conference. Profilaktychna medycyna. 2015;3/4(25):19-20. Russian.
Kishkun AA. [Immunological and serological studies in clinical practice]. Мoskva, Meditsinskoe informatsionnoe agenstvo. 2006;536. Russian.
Volikova OO, Shostakovych-Koretskaya LR, Lytvyn KY, Kushnjerova OA, Petul'ko AP, Panykova TN. [Laboratory diagnostic of immunosuppression level in HIV-infected patients]. Scientific and Practical Conference. Profilaktychna medycyna. 2016;3-4 (27):37-38. Ukrainian.
Mavrutenkov VV. [Herpesvirus infection type IV: immunopathogenesis, clinic, diagnosis and treatment]. [dissertation]. 14.01.13. Dnipropetrovs'k, 2008;296. Ukrainian.
Procjuk RG. [Features of pulmonary tuberculosis in HIV-infected patients and patients with AIDS]. Ukraynskyj pul'monologycheskyj zhurnal. 2007;4:9-13. Ukrainian.
Rebrova Oyu. [Statistical analysis of medical data. Application of the STATISTICA software package]. Мoskva, MediaSfera 3. 2006;312. Russian.
Shostakovych-Koretskaya LR, Volikova OO, Lytvyn KY, Kushnjerova OA, Chykarenko ZO. [The role of genetic factors in predicting the transition of HIV infection and development of HIV-associated diseases]. GVKG MOZ Ukrai'ny. 2011;18:616-24. Ukrainian.
Volikova OO, Shostakovych-Koretskaya LR, Lytvyn KY, Kushnjerova OA, Rjeznik OS. [Role of ІІ class of histocompatibility in development of concominant diseases in HIV-infected patients]. Problemy vijs'kovoi' ohorony zdorov’ja. 2015;2(44):59-62. Ukrainian.
Khaitov RM, Alekseev LP. [Physiological role of the main complex of human histocompatibility]. Immunologiya. 2001;3:37-42. Russian.
Lombard Z, et al. Association of HLA-DR,-DQ, and vitamin D receptor alleles and haplotypes with tuberculosis in the Venda of South Africa. Human immunology. 2006;67(8):643-54.
Lawn S, Churchyard G. Epidemiology of HIV associated tuberculosis. Curr. Opin. HIV AIDS. 2009;4:325-33.
Corbett EL, Watt CJ, Walker N, Maher D, Williams BG, Raviglione MC, et al. The growing burden of tuberculosis: Global trends and interactions with the HIV epidemic. Arch. Intern. Med. 2003;163:1009–21.
Trachtenberg Elizabeth A., and Erlich Henry A. A review of the role of the human leukocyte antigen (HLA) system as a host immunogenetic factor influencing HIV transmission and progression to AIDS. HIV Molecular Immunology. 2001;I43:43-60.
Volikova OA. Correlation of locus alleles of DRB1 II class of histocompatibility complex with clinical, immunological and virological parameters in HIV infection. European science review. 2015;9-10:48-50.
##submission.downloads##
Як цитувати
Номер
Розділ
Ліцензія
Авторське право (c) 2017 Медичні перспективи
Ця робота ліцензується відповідно до Creative Commons Attribution 4.0 International License.
Submitting manuscript to the journal "Medicni perspektivi" the author(s) agree with transferring copyright from the author(s) to publisher (including photos, figures, tables, etc.) editor, reproducing materials of the manuscript in the journal, Internet, translation into other languages, export and import of the issue with the author’s article, spreading without limitation of their period of validity both on the territory of Ukraine and other countries. This and other mutual duties of the author and all co-authors separately and editorial board are secured by written agreement by special form to use the article, the sample of which is presented on the site.
Author signs a written agreement and sends it to Editorial Board simultaneously with submission of the manuscript.
