Neurotropic action of soy lecithin in the process of cognitive function formation in white rats.
DOI:
https://doi.org/10.26641/2307-0404.2015.1.40230Keywords:
soy lecithin, polyunsaturated fatty acids (PUFAs), cognitive functionAbstract
In experiments conducted on white rats neurotropic action of soy lecithin, known as a source of unsaturated fatty acids on the background of the neurotoxic impact of CCl4was studied. Useage of CCl4by courses showed a significant inhibitory effect that affected the spontaneous behavior of rats “in the open field” by significant inhibition of mobility (44 - 77%), research activity (81%) and increased emotionality (140%). Suchusageofsoy lecithin having anti-oxidant activity and membrane-stabilizing effect led to optimization of spontaneous behavior of rats. Theinfringement of cognitive function is, possibly, due to the prooxydative effect ofCCl4 anddecreaseintheunsaturated fatty acid fraction in the structure of the brain lipids.Level of research, mink instinct, emotionality, vertical mobility were restored, and horizontal mobility even increased by 59%. Thus, soy lecithin may be recommended as a drug with correcting cognitive brain function.
References
Drobot LB, Samojlenko AA, Vorotnikov AV. [Reactive oxygen species in signal transduction]. 2013;6:819-25. Russian. 2. Buresh Ya. [Techniques and basic experiments to study the brain and behavior]. 1991;399. Russian. 3. Galkina OV. [Features of free radical processes and antioxidant protection of the adult brain] Neurochemistry. 2013;30(2):93-98. Russian. 4. Kokunin VA. [Statistical data processing with a small number of experiments]. Ukrainian Biochemical Journal. 1975;47(6): 776-91. Russian. 5. Midzjanovskaja IS, Folomkina AA, Koshtojanc OH. [The concentration of serotonin and its metabolite 5-HIAA in brain structures of Wistar rats and Way / Rij, impact of impiramin on peak-wave activity] Neurochemistry. 2010;27(3):238-44. Russian. 6. Mikitjuk VV, Gluh ІS, Shul'ga SM. [Lecithin as a factor in obtaining animal products]. 2010;114. Ukrainian. 7. Privrockaja IB, Kuchmerovskaja TM. [Oxidative stress in blood leukocytes pro / antioxidative status and fatty acid composition of lipids of the pancreas in experimental acute pancreatitis in rats]. Ukrainian Biochemical Journal. 2013;5:711-18. Russian. 8. Titov VN, Vostrov IA, Shirjaeva JuK. [Coming-to-be in phylogeny of lipoproteins of low and very low density and insulin. Lipotoxicity of fatty acids and lipids. Positional isomers of triglycerides]. The successes of modern biology. 2012;32(5):506-26. Russian. 9. Ukolova TN, Aljohina TA, Meshkov IO. [Postural-motor reactions and distribution of brain monoamines in rats of Catatonic line in early ontogenesis] Neurochemistry. 2012;29(2):128-33. Russian. 10. Almedia PFF. Thermodynamics of lipid interaction in complex bilayers. Biohim Biophes.Acta. 2009;1788:72-85. 11. Simons K. Membrane organization and lipid rafts. Cold Spring Harb. Perspect. Biol. 3 2011. – a004697.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2017 Medical Perspectives
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Submitting manuscript to the journal "Medicni perspektivi" the author(s) agree with transferring copyright from the author(s) to publisher (including photos, figures, tables, etc.) editor, reproducing materials of the manuscript in the journal, Internet, translation into other languages, export and import of the issue with the author’s article, spreading without limitation of their period of validity both on the territory of Ukraine and other countries. This and other mutual duties of the author and all co-authors separately and editorial board are secured by written agreement by special form to use the article, the sample of which is presented on the site.
Author signs a written agreement and sends it to Editorial Board simultaneously with submission of the manuscript.
