Neurotropic action of soy lecithin in the process of cognitive function formation in white rats.
DOI:
https://doi.org/10.26641/2307-0404.2015.1.40230Ключевые слова:
soy lecithin, polyunsaturated fatty acids (PUFAs), cognitive functionАннотация
In experiments conducted on white rats neurotropic action of soy lecithin, known as a source of unsaturated fatty acids on the background of the neurotoxic impact of CCl4was studied. Useage of CCl4by courses showed a significant inhibitory effect that affected the spontaneous behavior of rats “in the open field” by significant inhibition of mobility (44 - 77%), research activity (81%) and increased emotionality (140%). Suchusageofsoy lecithin having anti-oxidant activity and membrane-stabilizing effect led to optimization of spontaneous behavior of rats. Theinfringement of cognitive function is, possibly, due to the prooxydative effect ofCCl4 anddecreaseintheunsaturated fatty acid fraction in the structure of the brain lipids.Level of research, mink instinct, emotionality, vertical mobility were restored, and horizontal mobility even increased by 59%. Thus, soy lecithin may be recommended as a drug with correcting cognitive brain function.
Библиографические ссылки
Drobot LB, Samojlenko AA, Vorotnikov AV. [Reactive oxygen species in signal transduction]. 2013;6:819-25. Russian. 2. Buresh Ya. [Techniques and basic experiments to study the brain and behavior]. 1991;399. Russian. 3. Galkina OV. [Features of free radical processes and antioxidant protection of the adult brain] Neurochemistry. 2013;30(2):93-98. Russian. 4. Kokunin VA. [Statistical data processing with a small number of experiments]. Ukrainian Biochemical Journal. 1975;47(6): 776-91. Russian. 5. Midzjanovskaja IS, Folomkina AA, Koshtojanc OH. [The concentration of serotonin and its metabolite 5-HIAA in brain structures of Wistar rats and Way / Rij, impact of impiramin on peak-wave activity] Neurochemistry. 2010;27(3):238-44. Russian. 6. Mikitjuk VV, Gluh ІS, Shul'ga SM. [Lecithin as a factor in obtaining animal products]. 2010;114. Ukrainian. 7. Privrockaja IB, Kuchmerovskaja TM. [Oxidative stress in blood leukocytes pro / antioxidative status and fatty acid composition of lipids of the pancreas in experimental acute pancreatitis in rats]. Ukrainian Biochemical Journal. 2013;5:711-18. Russian. 8. Titov VN, Vostrov IA, Shirjaeva JuK. [Coming-to-be in phylogeny of lipoproteins of low and very low density and insulin. Lipotoxicity of fatty acids and lipids. Positional isomers of triglycerides]. The successes of modern biology. 2012;32(5):506-26. Russian. 9. Ukolova TN, Aljohina TA, Meshkov IO. [Postural-motor reactions and distribution of brain monoamines in rats of Catatonic line in early ontogenesis] Neurochemistry. 2012;29(2):128-33. Russian. 10. Almedia PFF. Thermodynamics of lipid interaction in complex bilayers. Biohim Biophes.Acta. 2009;1788:72-85. 11. Simons K. Membrane organization and lipid rafts. Cold Spring Harb. Perspect. Biol. 3 2011. – a004697.
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