The mixed impact of chemical and physical factors on reproductive system of rats in conditions of cold stress.

Authors

  • I. V. Zavgorodnii
  • R. O. Bachіnskyi
  • D. P. Pertsev
  • O. L. Litovchenko
  • N. I. Gorgol

DOI:

https://doi.org/10.26641/2307-0404.2016.4.90777

Keywords:

reproductive system, nіtrobenzol, methyl tertiary butyl ether, electromagnetic radiation, cold stress, gonadotoxic action, mixed impact

Abstract

The results of experimental investigations on studying features of gonadotoxic effect of nitrobenzene (NB), methyl tertiary butyl ether (MTBE) and electromagnetic radiation (EMR) both in conditions of cold stress and in conditions of thermal acceptability are given. The investigations were carried out on laboratory animals, in 30-fold intragastric administration of NB or MTBE in a dose of 1/10 LD50 and exposition of animals in two different thermal regimens – 4 hours a day, 5 times a week. Effect of EMR was simulated in 70 kHz frequency, 600 V/m voltage.The features of gonadotoxic effect of NB and MTBE were studied by the indices of spermatozoa functional state, general histological  analysis of the state of testicle tissues, supplemented with morphometric values, was carried out,. The analysis of results of experimental research proves that morpho-functional changes of reproductive system in laboratory animals during the influence of chemical factors (NB and MTBE), physical factors (EMR) in two different thermal regimens are similar provided that there is the increase of gonadotoxic effect in mixed effect of mentioned factors and decreased temperature.

Author Biographies

I. V. Zavgorodnii

Kharkiv National Medical University
Av. Nauky, 4, Kharkiv, 61022, Ukraine

R. O. Bachіnskyi

Kharkiv National Medical University
Av. Nauky, 4, Kharkiv, 61022, Ukraine

D. P. Pertsev

Kharkiv National Medical University
Av. Nauky, 4, Kharkiv, 61022, Ukraine

O. L. Litovchenko

Kharkiv National Medical University
Av. Nauky, 4, Kharkiv, 61022, Ukraine

N. I. Gorgol

Kharkiv National Medical University
Av. Nauky, 4, Kharkiv, 61022, Ukraine

References

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Yavorovskyi OP, Paustovskyi IuO. [Features of working conditions and health of workers employed in manufacturing and application of metyl tret-butyl ether refineries Ukraine]. Dovkillia ta zdorov’ia. 2008;3(46):60-63. Ukrainian.

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Published

2016-12-22

How to Cite

1.
Zavgorodnii IV, Bachіnskyi RO, Pertsev DP, Litovchenko OL, Gorgol NI. The mixed impact of chemical and physical factors on reproductive system of rats in conditions of cold stress. Med. perspekt. [Internet]. 2016Dec.22 [cited 2024Dec.24];21(4):28-32. Available from: https://journals.uran.ua/index.php/2307-0404/article/view/90777

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Section

THEORETICAL MEDICINE