Clinical, microbiological, immunological and metabolic features of purulent process occurrence in the periodontium in patients with chronic generalized periodontitis.

Authors

  • А. А. Gudaryan
  • N. B. Kuznyak
  • I. I. Dronik

DOI:

https://doi.org/10.26641/2307-0404.2016.4.91472

Keywords:

generalized periodontitis, lipid peroxidation, immunodeficiency, biocenosis

Abstract

Significance of processes of freelipid peroxidation, local immunological disorders and features of biocenosis of periodontal tissues and their role in the occurrence of purulent process in the periodontium in 64 patients with chronic generalized periodontitis of I-II severity degree is proved. By total of results of clinical, microbiological and metabolic studies in patients it was showed, that formation of purulent process in periodontal tissues is due to the dominance in the gingival econiche of staphylococus, fuzospiliar infection, deficiency of secretory immunity of the oral mucosa, intensity of lipid peroxidation and inhibition of antioxidant protection. It was found that the normalization of the levels of immunoglobulins, especially of sIgA, cytokines (IL-1β, TNF-α), the operation of POL and AOP are the main markers of improved clinical picture of the disease.

Author Biographies

А. А. Gudaryan

SE «Dnipropetrovsk medical academy of Health Ministry of Ukraine»
Oral surgery, implantology and periodontology department
Dzerzhinsky str., 9, Dnipro, 49044, Ukraine

N. B. Kuznyak

SE «Bukovinian state medical university» 
Department of prosthetic dentistry
Theatralna sq., 2, Chernivtsi, 58002, Ukraine

I. I. Dronik

SE «Bukovinian state medical university»
Department of prosthetic dentistry
Theatralna sq., 2, Chernivtsi, 58002, Ukraine

References

Grudyanov AI. [Periodontal diseases]. Moscow: Publishing House "Medical Information Agency". 2009;336. Russian.

Mashchenko IS. [Periodontal disease]. Dnepro-petrovsk: Colo. 2003;271. Russian.

Muller HP. [Periodontics]. L'vov. GalDent. 2004;256. Russian.

Cochran D.L. Inflammation and bone loss in pe-riodontal disease. Periodontol. 2008;79:1569-76.

Delves PJ, Roitt IM. The immune system. Second of two parts. J Med. 2000;343:108-17.

Kebschull M, Papapanou PN. Periodontal micro-bial complexes associated with specific cell and tissue responses. J Clin Periodontol. 2011;38:17-27.

Michael PM. Immunological and Inflammatory Aspects of Periodontal Disease. Continuing Education Course. 2013;1-18.

Socransky SS, Haffajee AD. Periodontal micro-bial ecology. Periodontol 2005;38:135-187.

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Published

2016-12-22

How to Cite

1.
Gudaryan АА, Kuznyak NB, Dronik II. Clinical, microbiological, immunological and metabolic features of purulent process occurrence in the periodontium in patients with chronic generalized periodontitis. Med. perspekt. [Internet]. 2016Dec.22 [cited 2024Jul.21];21(4):98-105. Available from: https://journals.uran.ua/index.php/2307-0404/article/view/91472

Issue

Section

CLINICAL MEDICINE