Prediction of treatment results of low-grade gliomas of the cerebral hemispheres.

Authors

  • A. G. Sirko
  • L. A. Dzyak
  • O. I. Balashova
  • T. L. Berdova
  • G. N. Donchenko
  • N. V. Skljar
  • N. N. Shestakova
  • D. N. Romanukha

DOI:

https://doi.org/10.26641/2307-0404.2017.3.111926

Keywords:

low-grade gliomas, anaplastic astrocytoma, glioblastoma, surgery, gross-total resection, adjuvant therapy, survival, Kaplan-Meier

Abstract

Glial tumors are the most common primary neoplasms of the central nervous system. Their proportion in the total structure of primary brain tumors is 50-65%. In Ukraine, according to the statistical data of the cancer-registry of the year 2014, 49,3% of patients with primary diagnosed malignant neoplasms of the brain did not live for one year. The aim of the study was to improve the survival rates of patients with low-grade glial tumors (LGT) (grade III-IV) by determining optimal treatment strategy and main prognostic survival factors. A prospective study of the results of treatment of patients with LGT from 2009 to 2014 was conducted. The study consistently included 100 operated patients with LGT (anaplastic astrocytoma (AA) and glioblastoma (GLB)). The median survival in the total group of patients (n=100) was 363.5 days (12 months). The main statistically significant prognostic factors of survival were: the completeness of tumor removal (p=0.00000000007) and the character of adjuvant therapy (p=0.000012). With the removal of LGT III-IV grade aplasias, which do not spread to functionally important areas and deep areas of the brain, one should try to perform Gross-total resection (GTR), which ensures long-term survival. The median survival of patients after GTR was 22.3 months. An integrated approach to the treatment which includes surgery, adjuvant radiotherapy and monochemotherapy with temozolamide showed the best survival rates – 20.5 months.

Author Biographies

A. G. Sirko

SE «Dnipropetrovsk medical academy of Health Ministry of Ukraine»
V.Vernadsky str., 9, Dnipro, 49044, Ukraine
«Dnipropetrovsk Regional Clinical Hospital named after I.I. Mechnikov» **
Soborna sq., 14, Dnipro, 49005, Ukraine

L. A. Dzyak

SE «Dnipropetrovsk medical academy of Health Ministry of Ukraine»
V.Vernadsky str., 9, Dnipro, 49044, Ukraine

O. I. Balashova

SE «Clinical Oncology Dispensary» of DRC ***
Havrylenko str., 1, Dnipro, 49055, Ukraine

T. L. Berdova

SE «Clinical Oncology Dispensary» of DRC ***
Havrylenko str., 1, Dnipro, 49055, Ukraine

G. N. Donchenko

SE «Clinical Oncology Dispensary» of DRC ***
Havrylenko str., 1, Dnipro, 49055, Ukraine

N. V. Skljar

SE «Clinical Oncology Dispensary» of DRC ***
Havrylenko str., 1, Dnipro, 49055, Ukraine

N. N. Shestakova

SE «Clinical Oncology Dispensary» of DRC ***
Havrylenko str., 1, Dnipro, 49055, Ukraine

D. N. Romanukha

SE «Dnipropetrovsk medical academy of Health Ministry of Ukraine»
V.Vernadsky str., 9, Dnipro, 49044, Ukraine

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How to Cite

1.
Sirko AG, Dzyak LA, Balashova OI, Berdova TL, Donchenko GN, Skljar NV, Shestakova NN, Romanukha DN. Prediction of treatment results of low-grade gliomas of the cerebral hemispheres. Med. perspekt. [Internet]. 2017Oct.12 [cited 2024Dec.22];22(3):52-9. Available from: https://journals.uran.ua/index.php/2307-0404/article/view/111926

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CLINICAL MEDICINE