Possibilities of personalized therapy in patients with chronic pelvic pain and inflammatory diseases of the pelvic organs.
DOI:
https://doi.org/10.26641/2307-0404.2018.4.153001Keywords:
chronic pelvic pain, inflammatory diseases of the pelvic organs, interleukins, personalized therapyAbstract
The aim of our study was to create a pathogenetically determined systemic approach to improve the treatment and the psycho-emotional state of a woman with chronic pelvic pain and inflammatory diseases of the pelvic organs through the individualization of therapeutic and rehabilitation tactics on the basis of the study of immune-hormonal relations, and psychopersonal characteristics of thematic patients.A comparative evaluation of the cytokine (IL-10, IL-6, TNF-α) and hormonal profile (luteinizing hormone (LH), follicle-stimulating hormone (FSH), estradiol, progesterone, prolactin,cortisol) was carried out as well as; monitoring of pain and psycho-emotional disorders of the dynamics of observation.In the dynamics of observation after the treatment for 6 months it was noted: a decrease in the pro-inflammatory activity of the cytokine profile: IL-6 by 43.28%, TNF-α by 63.27%;recovery of hormonal ratios – in76% of women;88% of patients identified a significant improvement in general and psychoemotional state;reduction of reactive anxiety and depressive disorders to normal values was determined in 84% of patients; regression of pain syndrome to the minimum indices according to the VAS scale was determined in 96% of patients. This demonstrates the effectiveness of personalized therapy and the possibility of expanding the therapeutic - diagnostic algorithm in patients with chronic pelvic pain.
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