Features of hormonal function in pregnant women - displaced persons.
DOI:
https://doi.org/10.26641/2307-0404.2019.2.170146Keywords:
pregnancy, stress-associated hormones, hormones of the fetoplacental complex, pregnant women - displaced personsAbstract
Harmonious and stable psycho-emotional state of pregnant women is an important condition of successful pregnancy course, fetal development and physiological childbirth. People are facing various problems related to mental health that vary from psycho-emotional stress to the mental disorders. Important factors that determine the physiology of pregnancy are the psycho-emotional state of the pregnant and fetoplacental complex. Among the consequences of severe stress during pregnancy is dizziness, tachycardia, trembling of limbs, elevated arterial pressure, unmotivated increase in nervousness and anxiety, sleep disorder, depression that lead to worsening of general condition of a future mother. The purpose of the study was to determine changes in the production of placental hormones and stress-associated hormones in pregnant women - displaced persons. To carry out the study, a randomised dynamic prospective clinical-paraclinical examination of 96 pregnant women (the main group) - displaced persons and 39 pregnant women (control group), who lived permanently in the territory of Ukraine under control, with gestation period after 22 weeks was used. Concentration of stress-associated (cortisol and prolactin) and placental (estradiol, progesterone, placental lactogen) hormones in serum was determined by solid-phase immunoassay. Increased estradiol concentrations and relative reductions in progesterone and placental lactogen, displacement of estrogen-progesterone equilibrium toward relative hyperestrogeny, increase in the concentration of stress-associated hormones were observed. The revealed hormonal and metabolic disorders in pregnant women, internally displaced persons, are biochemical markers of placental dysfunction, which testifies to the expediency of a comprehensive preconceptional preparation with the involvement of a psychologist and inclusion of preventive measures in the form of long-term progesterone support during pregnancy in the program of antenatal observation of such women.References
Astahov VM, Bacyleva OV, Puz IV. [Psychological support of pregnant women in modern conditions]. Zdorove zhenschiny. 2014;4(90):58-61. Russian.
Zhabchenko IA, Oleshko VF, Bondarenko OM, Syudmak OR. [Features of hormonal homeostasis in pregnant women with functional disorder of the obstructive function of the cervix]. Reproduktivnaya endokrinologiya. 2016;5(31):85-89. Ukrainian. doi: https://doi.org/10.18370/2309-4117.2016.31.85-89.
Zhuk SI, Shurevskaya OD. [Stress fetal programming]. Zdorovie zhenschiny. 2017;1(117):116-9. Ukrainian.
Larina AA, Grigoryan OR, Andreeva EN, Dzeranova LK. [Hyperprolactinemia and pregnancy - review of literature]. Problemyi reproduktsii. 2013;3:13-17. Russian.
Malgozhata Zyigmunt, Yatsek Sapa. [Progesterone – a new look at an old drug]. Reproduktivnaya endokrinologiya. 2017;1(33):17-25. Russian. doi: https://doi.org/10.18370/2309-4117.2017.33.17-25.
Malgina GB, Vetchanina EG, Pronina TA. [Perinatal problems associated with psychoemotional stress during pregnancy and their correction]. Materials of the All-Russian Conference with international participation «Perinatalnaya psihologiya i meditsina»,Ivanovo, 2001;35-38. Russian.
[Order of the Ministry of Health ofUkrainedated July 15, 2011 N 417 “Methodological recommendations for the provision of ambulatory obstetric and gynecological care”]. Kyiv; 2011. Ukrainian.
Moskalenko VF. [Biostatistika]. Kyiv. 2009;184. Ukrainian.
8 disturbances of high estrogen. Available from: https://ukr.media/medicine/379194/. Ukrainian.
Sebko TV, Heydar LA, Koneeva SS. [Hyperprolactinemia]. Rossiyskiy meditsinskiy zhurnal. 2016;22(5):250-9. Russian.
Tatarchuk TF. [Stress and reproductive function of women]. Mezhdunarodnyi endokrinologicheskiy zhurnal. 2006;3(5). Russian.
Trishkin AG. [The information content of the determination of placental lactogen and free estriol for the diagnosis of chronic placental insufficiency]. Zhurnal akusherstva i zhenskih bolezney. 2011;LX(2):63-67. Russian.
Trishkin AG, Novikova ON, Artymuk NV, Ushakova GA, Kiprina ES, Bikmetova ES. [Hormonal and metabolic characteristics of fetoplacental complex in women with fetal growth retardation]. Mat i ditya v Kuzbasse (Spetsvyipusk 1). 2012;59-63. Russian.
Katarzyna Zielniok, Małgorzata Gajewska, Tomasz Motyl. Molecular actions of 17β-estradiol and progesterone and their relationship with cellular signaling pathways. Postepy Hig Med Dosw. 2014;68:777-92. doi: https://doi.org/10.5604/17322693.1108390
Downloads
How to Cite
Issue
Section
License
Copyright (c) 2019 Medicni perspektivi (Medical perspectives)
This work is licensed under a Creative Commons Attribution 4.0 International License.
Submitting manuscript to the journal "Medicni perspektivi" the author(s) agree with transferring copyright from the author(s) to publisher (including photos, figures, tables, etc.) editor, reproducing materials of the manuscript in the journal, Internet, translation into other languages, export and import of the issue with the author’s article, spreading without limitation of their period of validity both on the territory of Ukraine and other countries. This and other mutual duties of the author and all co-authors separately and editorial board are secured by written agreement by special form to use the article, the sample of which is presented on the site.
Author signs a written agreement and sends it to Editorial Board simultaneously with submission of the manuscript.
