Allergic and non-allergic skin diseases in children of Ukraine: a retrospective study of the prevalence and incidence over the past 24 years

O.P. Volosovets; Yu.K. Bolbot; G.V. Beketova; V.S. Berezenko; T.R. Umanets; O.O. Rechkina; I.O. Міtiuriaeva-Korniyko; T.М. Volosovets; T.V.  Pochinok

doi:10.26641/2307-0404.2021.3.242265

Authors

O.P. Volosovets Bogomolets National Medical University, T. Shevchenko blvd., 13, Kyiv, 01601, Ukraine https://orcid.org/0000-0001-7246-0768
Yu.K. Bolbot Dnipro State Medical University, V. Vernadsky str., 9, Dnipro, 49044, Ukraine https://orcid.org/0000-0001-5679-1700
G.V. Beketova Shupyk National Healthcare University of Ukraine, Dorohozhytska str., Kyiv, 04112, Ukraine https://orcid.org/0000-0002-8400-4580
V.S. Berezenko Bogomolets National Medical University, T. Shevchenko blvd., 13, Kyiv, 01601, Ukraine https://orcid.org/0000-0002-3777-5251
T.R. Umanets State organization «Academician Lukyanova Institute of Pediatrics, Obstetrics and Gynecology of the National Academy of Medical Sciences of Ukraine», P. Mayboroda str., 8, Kyiv, 04050, Ukraine https://orcid.org/0000-0001-9058-7383
O.O. Rechkina State organization «National Institute of phthisiology and pulmonology named after F.G. Yanovski of the NAMS of Ukraine», Mykola Amosova str., 10, Kyiv, 03038, Ukraine https://orcid.org/0000-0002-7545-8572
I.O. Міtiuriaeva-Korniyko Bogomolets National Medical University, T. Shevchenko blvd., 13, Kyiv, 01601, Ukraine https://orcid.org/0000-0002-6757-3415
T.М. Volosovets Shupyk National Healthcare University of Ukraine, Dorohozhytska str., Kyiv, 04112, Ukraine https://orcid.org/0000-0001-9950-3748
T.V. Pochinok Bogomolets National Medical University, T. Shevchenko blvd., 13, Kyiv, 01601, Ukraine https://orcid.org/0000-0003-0802-2071

DOI:

https://doi.org/10.26641/2307-0404.2021.3.242265

Keywords:

children, allergic and non-allergic skin diseases, atopic dermatitis, incidence, prevalence, environment, pollutants

Abstract

Bacterial, allergic, parasitic and fungal skin lesions are much more common among children than among adult patients. The aim of this study was to analyze data on the prevalence and incidence of diseases of skin and subcutaneous tissue with allergic and non-allergic origin among children of Ukraine in period from 1994 to 2017. Our main purpose was to determine the possible impact of different adverse environmental factors on children`s growth, including radiation, connected with the Chernobyl disaster in 1986. Over the past 24 years Ukraine has witnessed a 10.3% increase in prevalence of diseases of skin and subcutaneous tissue among children and 8.6% raise of incidence rate with a predominance of detection of this pathology in children affected by the Chernobyl accident and children from areas of radiological control. We have found a direct influence of moderate strength on the connection between population-weighted effective dose of total human exposure (in millizieverts) in different regions of the country in the period of 1997-2011 and the incidence and prevalence of skin diseases among children aged 0-14 years, including 2011 (p<0.05).This fact may indicate the impact of this disaster on the occurrence and pathogenesis of skin diseases and its consequences among children. During the same period, due to the influence of a number of environmental factors, there was a significant transformation in the structure of skin diseases in children. We have witnessed double increasing of the proportion of allergic lesions of the skin and its elements. The prevalence of diseases of the skin and its elements in general has reached 28.7% against the corresponding reduction of skin infections.

References

Baloga VI, Kholosha VI, Evdin AI. [25 years of the Chernobyl disaster. Security of the future. National report of Ukraine. Radiological and medical consequences of the Chernobyl disaster]. Ministry of Emergencies of Ukraine. Kyiv. KIM; 2011. p. 367. Russian.

Kalyuzhna LD, Bardova SV, Vozianova SV, Mikhnʹova YeM, Murzina YeO. [Pediatric dermatovene¬reology]. Kyiv. Hramota: 2014. p. 303. Ukrainian.

Zabolotko VM. [Provision of medical care to children aged 0-17 in health care institutions under the management of the Ministry of Health of Ukraine: statistical and analytical reference book 1996-2019]. 2020. Ukrainian. Available from: https://www.ukrmedstat@medstat.gov.ua.

Rebrova OYu. [Statistical analysis of medical data. Application of Statistica applications]. Moskva: MediaSfera; 2018. p. 312. Russian.

Reznichenko NYu. [Allergic skin diseases in pediatric practice: features of clinical manifestations and therapeutic approaches]. Perinatologiya i pediatriya. 2016;4(68):89-93. Ukrainian. doi 10.15574/pp.2016.68.89

Serdyuk AM, Stus VP, Lyashenko VI. [Ecology of the environment and safety of life of the population in the industrial regions of Ukraine]. Dnepropetrovsk: Thresholds: 2011. p. 1-486. Ukrainian.

Shumna TE. [The main aspects of allergy diagnosis and treatment of children with atopic dermatitis, residents of the industrial region]. Asthma ta alerhiia. 2014;1:23-29. Ukrainian.

Allmon A, Deane K, Martin KL. (2015) Common Skin Rashes in Children. Am Fam Physician. 2015 Aug 1;92(3):211-216. PMID: 26280141

Kalhan TA, Loo EXL, Kalhan AC, Kramer MS, Karunakaran B, Un Lam C, Van Bever H, Shek LP, Goh A, Chong YS, Lee BW, Gluckman P, Kwek K, Saw SM, God¬frey K, Hsu CY. Atopic dermatitis and early childhood caries: Results of the GUSTO study. J Allergy Clin Immunol. 2017 Jun;139(6):2000-2003.. Epub 2017 Jan 23. doi: https://doi.org/10.1016/j.jaci.2016.10.038

Volosovets OP, Kryvopustov SP, Volosovets TM, Abaturov OE, Kryuchko TO. Changes in health status of child population of Ukraine after Chernobyl сatastrophe. Wiadomości Lekarskie.2019; LXXII (10):1974-1976.

Environment of Ukraine. Statistical yearbook. State Statistics Service of Ukraine. Kyiv, 2016. 225 p.

Özçelik S, Kulaç İ, Yazıcı M, Öcal E. Distribution of childhood skin diseases according to age and gender, a single institution experience. Turk Pediatri Ars. 2018 Jun 1;53(2):105-112. PMCID: PMC6089785. doi: https://doi.org/10.5152/TurkPediatriArs.2018.6431

Halpert E, Ibañez M, Chaparro R, Molina J, Torres M. Prevalence of skin diseases in children 1 to 6 years old in the city of Bogota, Colombia. World Allergy Organization Journal. December 2020;13, 12;100484 doi: https://doi.org/10.1016/j.waojou.2020.100484

Silverberg JI. Public Health Burden and Epidemiology of Atopic Dermatitis. Dermatol Clin. 2017 Jul;35(3):283-289. Epub 2017 Apr 22. PMID: 28577797. doi: https://doi.org/10.1016/j.det.2017.02.002

WHO Epidemiology and Management of Common Skin Diseases in Children in Developing Countries. WHO. 2014:1-54. Available from: https://www.who.int/maternal_child_adolescent/documents/fch_cah_05_12/en/