State of catecxolaminergine systems of the brain in forming of sydnocarb psychosis.
DOI:
https://doi.org/10.26641/2307-0404.2014.1.24489Keywords:
brain, catecholamins, neurospecific albumen S - 100, psychosisAbstract
Violations of mnestic reactions are one of substantial signs of disorders of nervous activity. On the basis of it, as a criterion of forming of experimental psychosis, in our supervisions, the state of processes of conditionally-reflex memory was studied in rats. To cover up mechanisms of derangements of conditionally reflex activity in the process of forming of psychotic symptomatic complex, maintenance of adrenalin, noradrenalinum and neurospecific albumen S - 100 in the brain structures, that take a direct part in the processes of memory was studied. Derangements of cognitive function, that are the result of neurotoxic action of sydnocarb, are related to reduction of maintenance of noradrenalinum in the frontal cortex, as well as adrenalin in the pons varolii. That is, sydnocarb psychosis is accompanied by reduction of activating role of the cortex and trunk structures, negatively affecting the state of mnestic reactions. In the hippocampus and striate body excitation causes violation of memory processes and on the contrary, concentration of noradrenalinum rose. Thus, the presented model of experimental psychosis, created by subacute introduction of sydnocarb, is an adequate and alternative methodology of psychotic disorders forming in animals resulted from direct participation of the catecholaminergetic systems of CNS.References
Базян А.С. Молекулярно-химические основы эмоциональных состояний и подкрепления / А.С. Ба¬зян, Г.А. Григорьян // Успехи физиол. наук.- 2006.- Т. 37, № 1.- С. 68-83.
Бородкин Ю.С. Фармакология краткосрочной па¬мяти / Ю.С. Бородкин, В.А. Крауз. – М.: Медицина, 1978. – 232 с.
Буреш Я. Методики и основные эксперименты по изучению мозга и поведения / Я. Буреш, О. Бу¬ре¬шова, П. Хьюстон. – М.: Высшая шк., 1991. – 400 с.
Григорьян Г.А. Проблема подкрепления. От це¬лостного поведения к нейрохимическим основам и развитию психопатологий / Г.А. Григорьян // Журнал высшей нервной деятельности им. И.П. Павлова. – 2005.- Т. 55, № 5.- С. 685-698.
Дроздов А.Л. Динамика нейроспецифического белка (NCAM) и лизосомных протеаз гиппокампа при формировании условной реакции активного избе¬га¬ния / А.Л. Дроздов, В.И. Черная // Вопросы мед. хи¬мии. – 2010 г.
Иззати-Заде К.Ф. Нарушения обмена серо¬тонина в патогенезе заболеваний нервной системы / К.Ф. Иззати-Заде, А.В. Баша, Н.Д. Демчук // Журн. неврологии и психиатрии им. С.С. Корсакова. – 2004. – № 9. – С. 62-70.
Лабораторные методы исследования в кли¬нике: справочник / В.В. Меньшиков, Л.Н. Делек¬тор¬с¬кая, Р.П. Золотницкая [и др.]; под ред. В.В. Мень¬шикова.-М.: Медицина, 1987. – 368 с.
Лакин Г.В. Биометрия / Г.В. Лакин – М.: Высшая шк., 1990. - 352 с.
Нейрометаболическая фармакотерапия / под ред. Е.М. Бурцева, О.А. Громова. – М., 2000.- С. 4-21.
Пептиды вазопрессинового ряда и поведение / Л.А. Громов, Г.В. Дзяк, А.Л. Дроздов, В.А. Крауз. – Д.: Пороги, 2009.-175 с.
Проблемы организации социально-психиатри¬ческой и психотерапевтической службы в Украине / Б.В. Михайлов, А.К. Напреенко, И.И. Кутько, А.И. Сер¬дюк [и др] // Вопросы пограничной психи¬а¬трии, психотерапии, мед. психологии. материалы науч.-практ. конф. – Харьков, 2008. – С. 4-12.
Раевский К.С. Функциональная роль и фарма¬кологическая регуляция дофаминергических систем мозга // Вестник РАМН. – 1998. - № 8. - С. 19-24.
Регістр лікарських засобів України / под ред. Стефанова О.В. – К., 2000. – 791 с.
Силькис И.Г. Влияние нейромодуляторов на синаптическую пластичность в дофаминергических структурах среднего мозга (гипотетический меха¬низм) // Журнал высшей нервной деятельности им. И.П. Павлова. – 2003. – Т. 53, № 4. – С. 464-479.
Участие дофаминергических систем мозга в развитии МФТП-индуцированного депрессивного сос¬то¬яния у крыс / Н.Б. Панкова, Н.А. Крупина, И.Н. Ор¬лова [и др.] // Журнал высшей нервной дея¬тельности. – 2007.- Т. 57, № 2. – С. 243-254.
Фармакоэкономический анализ использования рисполепта при лечении больных шизофренией / В.А. То¬чилов, Е.В. Снедков, В.Л. Семенов-Тян-Шан¬ский // Психиатрия и психофармакотерапия.-2002.-Т.4, № 2.-С. 1118-1123.
Davis L.M. Economics and schizophrenia: the real cost / L.M. Davis, M.F. Drummond // Br. J. Psy¬chiatr. – 1994. – Vol. 165, Suppl. 25. – P. 18-21.
Drozdov A.L. The parcipitation of the neuro¬specific protein inprocesses of learning of conditioned reflex memory / A.L. Drozdov, V.I. Chornaya // Abstr. Conf. Univer. Curie-Sclodowska. – Lublin, 2004. – Vol. XVII, N 2. – P. 265-268.
To model a psuchiatric disorder in animals: schizo¬phrenia as a reality test / B.K. Lipska, Ph.D. Daniel, R. Daniel, M.D. Weinberger // Neuropsychopharma¬co¬logy. – 2000. – N 23. – P. 223-239.
Ykoyama S. Clinical study S-100beta protein as marker of brain injury in surgery / S. Ykoyama // Kyobu. Geka. – 2005. – Vol. 84, N 15. – P. 1210-1215.
Bazyan A, Grigoryan GA. [Molecular and che¬mical bases of emotional states and reinforcements]. Us¬pekhi fiziologicheskikh nauk. 2006;37(1):68-83. Rus¬sian.
Borodkin S, Krausz VA. [Pharmacology short-term memory]. Medical. 1978:232. Russian.
Bures J, Bureshova O, Houston P. [Techniques and basic experiments for the study of the brain and povedeniya]. Vysshaya shkola. 1991:400. Russian.
Grigoryan GA. Problem reinforcements. [From the holistic behavior to neurochemical basis and de¬velopment of psychopathology]. Zhurnal vysshey nervnoy deyatel'nosti im. I.P. Pavlova. 2005;55(5):685-98. Rus¬sian.
Drozdov AL, Black VI. [Dynamics neurospecific protein (NCAM) and lysosomal proteases in the forma¬tion of hippocampal conditioned reaction of active avoidance]. Voprosy meditsinskoy khimii; 2010. Russian.
Izzat-Zadeh KF, Basha A, Demchuk ND. [Disor¬ders of serotonin in the pathogenesis of diseases of the nervous system]. Journal Nevrologii i psikhiatrii im. S.S. Korsakova. 2004;9:62-70. Russian.
Menshikov VV, Delektorskaya LN, Zolotnitskaya RP. [Laboratory Methods in the clinic: Directory]. Me¬dicine. 1987:368. Russian.
Lakin GV. [Biometrics]. M.: Vysshaya shkola. 1990;352. Russian.
Burceva EM, Gromova OA. [Neyrome¬tabo¬licheskie pharmacotherapy]. M. 2000:4-21. Russian.
Gromov LA, Dzyak GV, Drozdov AL, Kraus VA. [Peptides and vasopressin series povedenie]. Dnepro¬petrovsk: Porogu. 2009:175. Russian.
Mikhaylov BV, Napreenko AK, Kut'ko II, Serdyuk AI. [Problems of organization of social-psy¬chiatric and psychotherapeutic services in Ukraine. Bor¬der issues psychiatry, psychotherapy, honey. psychology. Proceedings of konferentsii]. Kharkiv. 2008:4-12. Russian.
Raevskiy KS. [The functional role and phar¬macological regulation of dopaminergic systems in the brain. The functional role and pharmacological regu¬lation of dopaminergic systems in the brain]. Bulletin of the Russian Academy of Medical Sciences. 1998;8:19-24. Russian.
Stefanova OV. [Register medicines Ukraine]. Kiev. 2000:791. Ukrainian.
Silkis IG. [Influence of neuromodulators on synaptic plasticity in the dopaminergic midbrain struc¬tures (hypothetical mechanism)]. Journal of Higher Ner¬vous Activity of I.P. Pavlov. 2003;53(4):464-79. Russian.
Pankov NB, Krupin NA, Orlov I. [Participation of dopaminergic systems in the brain in the development of MPTP-induced depressive state in rats]. Journal of Higher Nervous Activity. 2007;57(2):243-54. Russian.
Tochilov VA, Snedkov EV, Semenov-Tyan-Shanskiy VL, Bogdan EV, Svistun SYa, Morshchikhina LI. [Pharmacoeconomic analysis of the use of risperidone in the treatment of patients with schizophrenia]. Psy¬chiatry and psihofarmakoterapiya. 2002;4(2);1118-23. Russian.
Davis LM, Drummond MF. Economics and schizophrenia: the real cost. 1994;165(Suppl. 25):18-21.
Drozdov AL, Chornaya VI. The parcipitation of the neurospecific protein inprocesses of learning of conditioned reflex memory. Abstr. Conf. Univer. Curie-Sclodowska, Lublin. 2004;17(2):265-8.
Lipska BK, Daniel PhD, Daniel R, Weinberger MD. To model a psuchiatric disorder in animals: schi¬zophrenia as a reality test. Neuropsychopharmacology. 2000;23:223-39.
Ykoyama S. Clinical study S-100beta protein as marker of brain injury in surgery. Kyobu. Geka. 2005;84(15):1210-5.
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