Сhronic relapsing inflammatory optic neuropathy: diagnostic strategies and treatment (literature review)

T.I. Nehrych; M.B. Kopchak; S.Ya.  Kyryliuk

doi:10.26641/2307-0404.2023.2.283157

Authors

T.I. Nehrych Danylo Halytsky Lviv National Medical University, Pekarska str, 69, Lviv, 79010, Ukraine https://orcid.org/0000-0003-0170-511X
M.B. Kopchak Lviv regional clinical perinatal center, George Washington str, 6, Lviv, 79032, Ukraine https://orcid.org/0000-0002-0035-2132
S.Ya. Kyryliuk Municupal non-profit enterprise of Lviv regional council «Lviv regional clinical hospital», Chernihivska str, 7, Lviv, 79010, Ukraine https://orcid.org/0000-0001-9547-314X

DOI:

https://doi.org/10.26641/2307-0404.2023.2.283157

Keywords:

chronic relapsing inflammatory optic neuropathy, relapsing idiopathic optic neuropathy, diagnosis, treatment, review

Abstract

The article presents a review and analysis of scientific works on the problem of chronic relapsing inflammatory optic neuropathy, its diagnostic criteria and treatment methods. Chronic relapsing inflammatory optic neuropathy, first described in 2003, is an autoimmune inflammatory disease of the optic nerve of unknown etiology, accompanied by frequent painful episodes of optic neuritis, with a clear response to steroid therapy and relapses after its withdrawal. An analysis of foreign works published in the E-Library, CrossRef, PubMed, Web of Science, Scopus databases was carried out in order to systematize data on the etiology, pathogenesis, clinical manifestations, diagnostic criteria, differential diagnosis and treatment of this pathological condition. It has been established that chronic recurrent inflammatory optic neuropathy is a rare, recurrent, corticosteroid-dependent optic neuropathy in which there is no other neurological deficit, no etiological factor is identified and it is a diagnosis of exclusion. It is important to identify such patients because the appointment of appropriate immunosuppressive therapy causes remission of the disease.

References

Arzani M, Sahraian MA, Rezaei H, Moghadasi AN. Recurrent isolated optic neuritis: A study on 22 patients. Iran J Neurol. 2017;16(3):130-5. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5673985/pdf/IJNL-16-130.pdf

Benoilid A, Tilikete C, Collongues N, Arndt C, Vighetto A, Vignal C, et al. Relapsing optic neuritis: A multicenter study of 62 patients. Mult Scler. 2014;20:848-53. doi: https://doi.org/10.1177/1352458513510223

Kidd D, Burton B, Plant GT, Graham EM. Chronic relapsing inflammatory optic neuropathy (CRION). Brain. 2003;126:276-84. doi: https://doi.org/10.1093/brain/awg045

Chwalisz BK. Chronic relapsing inflammatory optic neuropathy (CRION). Arq Neuropsiquiatr. 2022;80(5):453-4. doi: https://doi.org/10.1093/brain/awg045

Dib El Jalbout N, Rizk M, Khoueir Z, Sadaka A. Chronic relapsing inflammatory optic neuropathy: an underdiagnosed cause of recurrent vision loss. Can J Ophthalmol. 2022;57(2):e59-e61. doi: https://doi.org/10.1016/j.jcjo.2021.08.003

Molina-Carrión LE, Lira-Tecpa J, Jiménez-Arellano MP, Cruz-Domínguez MP, Medina G. Disease course of Chronic Relapsing Inflammatory Optic Neuropathy (CRION) in a single care center. Arq Neuropsiquiatr. 2022;80(5):510-5. doi: https://doi.org/10.1590/0004-282x-anp-2021-0157

Petzold A, Plant G. Chronic relapsing inflammatory optic neuropathy: a systematic review of 122 cases reported. J Neurol. 2014;261:17-26. doi: https://doi.org/10.1007/s00415-013-6957-4

Wingerchuk DM, Lennon VA, Lucchineti CF, Pittock SJ, Weinshenker BG. The spectrum of neuro-myelitis optica. Lancet Neurol. 2007;6:805-15. doi: https://doi.org/10.1016/S1474-4422(07)70216-8

Brust JCM. Current Diagnosis & Treatment Neurology. 3rd Ed. McGraw-Hill Education; 2019. 624 р.

Matiello M, Lennon VA, Jacob A, Pittock SJ, Lucchineti CF, Wingerchuk DM, et al. NMO-IgG predicts the outcome of recurrent optic neuritis. Neurology. 2008;70:2197-200. doi: https://doi.org/10.1212/01.wnl.0000303817.82134.da

Petzold A, Pittock S, Lennon V, Maggiore C, Weinshenker BG, Plant GT. Neuromyelitis optica-IgG (aquaporin-4) autoantibodies in immune-mediated optic neuritis. J Neurol Neurosurg Psychiatry. 2010;81:109-11. doi: https://doi.org/10.1136/jnnp.2008.146894

De Seze J, Arndt C, Jeanjean L, Zephir H, Blanc F, Labauge P, et al. Relapsing inflammatory optic neuritis: is it neuromyelitis optica? Neurology. 2008;70:2075-6. doi: https://doi.org/10.1212/01.wnl.0000313375.20123.25

Waschbisch A, Atiya M, Schaub C, Derfuss T, Schwab S, Lee DH, et al. Aquaporin-4 antibody negative recurrent isolated optic neuritis: clinical evidence for disease heterogeneity. J Neurol Sci. 2013;331:72-5. doi: https://doi.org/10.1016/j.jns.2013.05.012

Lee HJ, Kim B, Waters P, Woodhal M, Irani S, Ahn S, et al. Chronic relapsing inflammatory optic neuro-pathy (CRION): a manifestation of myelin oligoden-drocyte glycoprotein antibodies. J Neuroinflamm. 2018;15:302. doi: https://doi.org/10.1186/s12974-018-1335-x

Akaishi T, Sato DK, Takahashi T, Nakashima I. Clinical spectrum of inflammatory central nervous system demyelinating disorders associated with antibodies against myelin oligodendrocyte glycoprotein. Neurochem Int. 2019;130:104319. doi: https://doi.org/10.1016/j.neuint.2018.10.016

Reindl M, Di Pauli F, Rostásy K, Berger T. The spectrum of MOG autoantibody-associated demyelinating diseases. Nat Rev Neurol. 2013;9:455-61. doi: https://doi.org/10.1038/nrneurol.2013.118

Hervás-García JV, Pagani-Cassara F. Neuropatía óptica inflamatoria recurrente crónica: revisión de la bibliografía. Rev Neurol. 2019;68:524-30. doi: https://doi.org/10.33588/rn.6812.2018261

Ramos-Fernández C, García-Oliva I, Reyes-Rodríguez MA, Francisco-Hernández F, Tandón-Cárdenes L, González-Hernández A. Neuropatía óptica inflamatoria recurrente crónica (CRION): a propósito de un caso. Arch Soc Canar Oftal. 2011;22:93-8.

Saini M, Khurana D. Chronic relapsing inflammatory optic neuropathy. Ann Indian Acad Neurol. 2010;13:61-3. doi: https://doi.org/10.4103/0972-2327.61280

Samra A, Ramtahal J. Recurrent subacute visual loss presenting in a 52-year-old Caucasian woman with chronic relapsing inflammatory optic neuropathy: a case report. J Med Case Rep. 2012;6:15. doi: https://doi.org/10.1186/1752-1947-6-15

Frohman L, DellaTorre K, Turbin R, Bielory L. Clinical characteristics, diagnostic criteria and therapeutic outcomes in autoimmune optic neuropathy. Br J Ophthalmol. 2009;93:1660-6. doi: https://doi.org/10.1136/bjo.2009.159350

Lee MD, Song BJ, Odel JG, Sadun AA. Bilateral vision loss responsive to corticosteroids. Surv Ophthalmol. 2013;58:634-9. doi: https://doi.org/10.1016/j.survophthal.2012.05.006

Frohman EM, Frohman TC, Zee DS, McColl R, Galetta S. The neuroophthalmology of multiple sclerosis. Lancet Neurol. 2009;4:111-21. doi: https://doi.org/10.1016/S1474-4422(05)00992-0

Beck RW, Trobe JD, Moke PS, Gal RL, Xing D, Bhatti MT, et al. High- and low-risk profiles for the development of multiple sclerosis within 10 years after optic neuritis: experience of the Optic Neuritis Treatment Trial. Arch Ophthalmol. 2003;121:944-9. doi: https://doi.org/10.1001/archopht.121.7.944

Nilsson P, Larsson EM, Maly-Sundgren P, Perkfet R, Sandberg-Wollheim M. Predicting the outcome of optic neuritis. Evaluation of risk factors after 30 years of follow up. J Neurol. 2005;252:396-402. doi: https://doi.org/10.1007/s00415-005-0655-9

Miller DH, Weinshenker BG, Filippi M, Banwell BL, Cohen JA, Freedman MS, et al. Differential diagnosis of suspected multiple sclerosis: a consensus approach. Mult Scler. 2008;14:1157-74. doi: https://doi.org/10.1177/1352458508096878

Voss E, Raab P, Trebst C, Stangel M. Clinical approach to optic neuritis: pitfalls, red flags and differential diagnosis. Ther Adv Neurol Disord. 2011;4:123-34. doi: https://doi.org/10.1177/1756285611398702

Bichuetti DB, Camargo AS, Falcao AB, Gonçalves FF, Tavares IM, De Oliveira EM. The retinal nerve fiber layer of patients with neuromyelitis optica and chronic relapsing optic neuritis is more severely damaged than patients with Multiple Sclerosis. J Neuroophthalmol. 2013;33:220-4. doi: https://doi.org/10.1097/WNO.0b013e31829f39f1

Plant GT, Sibtain NA, Thomas D. Hyperacute corticosteroid treatment of optic neuritis at the onset of pain may prevent visual loss: a case series. Mult Scler Int. 2011;815068. doi: https://doi.org/10.1155/2011/815068

Raimundo M, Fonseca C, Lemos J, Fonseca P. Central serous chorioretinopathy as a cause of vision loss in chronic relapsing inflammatory optic neuropathy. Am J Ophtalmol Case Rep. 2018;11:131-4. doi: https://doi.org/10.1016/j.ajoc.2018.06.013

Myers TD, Smith JR, Wertheim MS, Egan RA, Shults WT, Rosenbaum JT. Use of corticosteroid sparing systemic immunosuppression for treatment of cortico-steroid dependent optic neuritis not associated with demyelinating disease. Br J Ophthalmol. 2004;88:673-80. doi: https://doi.org/10.1136/bjo.2003.028472

Herrero-Latorre R, Fernández-Pérez S, De la Mata G, Idioipe M, Satué M, García-Martín E. A case of chronic relapsing inflammatory optic neuropathy (CRION). Acta Ophthalmologica. 2011;248(89):S329.

De Benito L, Muñoz L, Martínez M, Cortés C, De Andrés C. Recurrent bilateral inflammatory idiopathic optic neuropathy treated with mycophenolate mofetil: clinical and radiological course. Neuro-ophthalmology. 2005;29:149-59. doi: https://doi.org/10.1080/01658100500218053

Stiebel-Kalish H, Hammel N, Van Everdingen J, Huna-Baron R, Lee AG. Intravenous immunoglobulin in recurrent relapsing inflammatory optic neuropathy. Can J Ophthalmol. 2010;45:71-5. doi: https://doi.org/10.3129/i09-238

Kurz D, Egan RA, Rosenbaum JT. Treatment of corticosteroid dependent optic neuropathy with intravenous immunoglobulin. Am J Ophthalmol. 2005;140:1132-3. doi: https://doi.org/10.1016/j.ajo.2005.06.053

Somlai J, Kovács T. Neuro-Ophthalmology. 1st edition. Springer; 2016. 728 р.