Gender and age-related features in office and home blood pressure control in patients with uncomplicated hypertension in real clinical practice.
DOI:
https://doi.org/10.26641/2307-0404.2016.2.72130Keywords:
hypertension, home blood pressure, fixed drug combination, peryndopril, amlodipin, masked uncontrolled hypertensionAbstract
The aim of our work was the assessment of effectiveness of standardized algorithmic treatment based on fixed-dose combination of perindopril/amlodipine and gender and age-related differences for office and home blood pressure control in real clinical practice. Our study included 421 patients with uncomplicated arterial hypertension 204 (48.5%) patients aged60 years and older, 78 (18.5%) men (group 1), 126 (29,9%) women (group 2) and 217 (51,5%) patients younger than 60 years, 115 (27,3%) men (group 3) and 102 (24,2%) women (group 4). Home and office blood pressure measurements were performed with the standardized oscillometric automatic device with individually selected cuff. At visit 1, patients were given training and written instructions for home blood pressure measuring and recording (twice per day for 7 consecutive days before each of 5 next visit) and were prescribed a fixed-dose combination of perindopril/amlodipine, which, if needed, was followed by consecutive addition of indapamide SR, spironolactone, and moxonidine or doxazosin for target office blood pressure achievement(<140/90 mm Hg). We have identified gender and age-related differences in home blood pressure control, including lower incidence of achievement of recommended level (<135/85 mm Hg) in men younger of 60 years compared to women of the same age and persons over 60 years of both genders, which resulted in a greater incidence of masked uncontrolled hypertension in this group of patients at comparable level of adherence to treatment.
References
Radchenko GD, Slashcheva TG, Sirenko YuM, Mushtenko LO. [Gender differences of blood pressure control in patients with arterial hypertension]. Uk-rayins'kyy kardiolohichnyy zhurnal. 2015;4:34–44. Ukrainian.
Amosova EN, Rudenko YV, Rokita OI, et al. [Effectiveness of a unified step treatment algorithm to control blood pressure in patients with hypertension in ambulatory practice: PERFECT findings]. Sertse i sudyny. 2014;1:34–46. Ukrainian.
Kovalenko VM, Kornatzky VM. [Cardiologycal diseases as medical, social and socio-political problem]. Kyiv, 2014. Ukrainian.
Conen D, Aeschbacherv, Thijs L, et al. Age-Specific Differences Between Conventional and Ambu-latory Daytime Blood Pressure Values. Hypertension 2014:64:1073-9.
Kreutz R, Ammentorp B, Laeis P, de la Sierra A. Efficacy and Tolerability of Triple-Combination Therapy With Olmesartan, Amlodipine, and Hydrochlorothiazide: A Subgroup Analysis of Patients Stratified by Hyper-tension Severity, Age, Sex, and Obesity. J Clin Hy¬pertens. 2014;16:729-40.
Parati G, Stergiou S, Asmar R, et al. European Society of Hypertension guidelines for blood pressure monitoring at home: a summary report of the Second International Consensus Conference on Home Blood Pressure Monitoring. J. Hypertens. 2008;26:1505-30.
Mancia G, Fagard R, Narkiewicz K, et al. Guide-lines for themanagement of arterial hypertension TheTask Force for the management ofarterial hypertension of the European Society of Hypertension and of the European Society of Cardiology. Journal of Hypertension. 2013;31:1281-357.
Glynn LG, Murphy AW, Smith SM, et al. Interventions used to improve control of blood pressure in patients with hypertension. Cochrane Database of Syste-matic Reviews 2010. Art. No.: CD005182. DOI: 10.1002/14651858.CD005182.pub4
Borghi C, Tubach F, De Backer G, et al. Lack of control of hypertension in primary cardiovascular disease prevention in Europe: Results from the EURIKA study. International Journal of Cardiology DOI: Article In Press. Available: http://dx.doi.org/10.1016/j.ijcard.2016.05.044/
Franklin SS, O’Brien E, Thijs L, et al. Masked Hypertension A Phenomenon of Measuremen. Hyper-tension. 2015;65:16-20.
Sheppard JP, Fletcher B, Gill P, et al. Predictors of the Home-Clinic Blood Pressure Difference: A Sys¬tematic Review and Meta-Analysis. Am J Hypertens. 2016;29:614-25.
Girerd X, Fourcade J, Brillet G, et al. The com-pliance evaluation test: a validated tool for detection of nonadherence among hypertensive treated patients. Journal of Hypertension 2001;19:74.
Cuckson AC, Reinders A, Shabeeh H, Shennan AH. Validation of the Microlife BP 3BTO-A oscil¬lo¬metric blood pressure monitoring device according to a modified British Hypertension Society protocol. Blood Press. Monit 2002;7;319-24.
Sivén SS, Niiranen TJ, Kantola IM, Jula A. Whi¬te-coat and masked hypertension as risk factors for progression to sustained hypertension: the Finn-Home study. Journal of Hypertension. 2016;34:54-60.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2017 Medical Perspectives
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Submitting manuscript to the journal "Medicni perspektivi" the author(s) agree with transferring copyright from the author(s) to publisher (including photos, figures, tables, etc.) editor, reproducing materials of the manuscript in the journal, Internet, translation into other languages, export and import of the issue with the author’s article, spreading without limitation of their period of validity both on the territory of Ukraine and other countries. This and other mutual duties of the author and all co-authors separately and editorial board are secured by written agreement by special form to use the article, the sample of which is presented on the site.
Author signs a written agreement and sends it to Editorial Board simultaneously with submission of the manuscript.
