Histomorphological features of combined forms of tuberculosis and lung cancer.

Авторы

  • Y. F. Savenkov
  • Y. F. Koshak
  • I. A. Malcev
  • I. V. Korpusenko
  • P. E. Bakulin

DOI:

https://doi.org/10.26641/2307-0404.2017.1.100904

Ключевые слова:

pulmonary tuberculosis, lung cancer, post-tuberculosis changes, bronchopulmonary and mediastinal lymph nodes

Аннотация

The were studied pathological features of combined forms of tuberculosis and non-small cell lung cancer in 72 patients who underwent radical surgical resection interventionsfrom transsternal access with mediastinal lymph node dissection, with predominanceof pneumonectomy - 63.9%. There were identified three main categories of pathological changes: cancer on the background of post-tuberculosis changes, cancer in tuberculoma, cancer in the wall of the active cavity. Post-tuberculosis changes were presented by dense centers, fibrosis, cirrhosis areas, sanitized cavities with histological predominance of coarse fiber connective tissue with giant cellgranulomas, with areas characterized by the appearance of the lung tissue with atypical proliferation and metaplasia of bronchopulmonary epithelium, which is a precancerous condition. This malignant tumor process was presented mainly by adenocarcinomas and squamous cell cancer and differred by polymorphic macro- and microscopic picture. Cancer intuberculoma and fibrous wall cavity differed by pronounced activity of tuberculosis process in the form of lymphohistiocytic infiltration, foci of caseous necrosis and presence of expressed granulation layer of Pirogov-Langhans’cells. The basic morphological causes of carcinogenesis due to secondary changes of lung tissue in patients with tuberculosis were determined. The features of metastasis of malignant tumors on the background of specific tuberculous and post-tuberculosis changes in regional lymph nodes and the interrelation between the frequency of metastatic lesions with severity of tuberculosis and post-tuberculosis changes in them were studied; this has clinical significance in the surgical treatment of patients with concomitant forms of tuberculosis and lung cancer.

Биографии авторов

Y. F. Savenkov

CE «Dnepropetrovsk regional clinical therapeutic and preventive association" Phthisiology» DRC *
Bekhtereva str., 12, Dnipro, 49000, Ukraine

Y. F. Koshak

Ternopil regional antitubercular dispensary STMO «Phthisiology» **
Pidlisna str., 26a, vil. Velyki Gai', Ternopil district, Ternopil region

I. A. Malcev

SE «Dnipropetrovsk medical academy of Health Ministry of Ukraine» ***
Department of Pathological Anatomy
Department of Surgery N 2
Dzerzhinsky str., 9, Dnipro, 49044, Ukraine

I. V. Korpusenko

SE «Dnipropetrovsk medical academy of Health Ministry of Ukraine» ***
Department of Pathological Anatomy
Department of Surgery N 2
Dzerzhinsky str., 9, Dnipro, 49044, Ukraine

P. E. Bakulin

CE «Dnepropetrovsk regional clinical therapeutic and preventive association" Phthisiology» DRC *
Bekhtereva str., 12, Dnipro, 49000, Ukraine

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Загрузки

Опубликован

2017-04-04

Как цитировать

1.
Savenkov YF, Koshak YF, Malcev IA, Korpusenko IV, Bakulin PE. Histomorphological features of combined forms of tuberculosis and lung cancer. Med. perspekt. [Интернет]. 4 апрель 2017 г. [цитируется по 22 декабрь 2024 г.];22(1):61-8. доступно на: https://journals.uran.ua/index.php/2307-0404/article/view/100904

Выпуск

Том 22 № 1 (2017)

Раздел

CLINICAL MEDICINE

Лицензия

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