Characteristics of sputum cellular composition in patients with chronic obstructive pulmonary disease of professional etiology.
DOI:
https://doi.org/10.26641/2307-0404.2018.3(part1).142342Ключевые слова:
diseases of bronchopulmonary apparatus, inflammation, cytogram, sputumАннотация
Inhalation of high concentrations of various types of dust, in particular of inorganic origin, leads to disruption of the normal mechanism of lung cleaning. A consequence of this is the development of inflammation of the airways with the formation of COPD. The inflammatory response of the airways with exacerbation of COPD is accompanied by the increase in the total number of neutrophils and lymphocytes. This heterogeneous cellular infiltrate is the source of specific biologically active substances that play a significant role in the structural and functional changes in the mucous membrane of the bronchopulmonary system. Sputum formation is one of the main clinical symptoms of respiratory diseases. By the parameters of the cellular composition of sputum, it is possible to determine the pathogenetic variant and the severity of the inflammatory response of the respiratory mucosa. The aim of the work was to study the cellular composition in the spontaneous sputum of COPD patients of mining industry. Cytological and statistical methods of investigation were used to achieve this goal. The study of the characteristics of the cell composition of sputum, depending on the degree of severity of COPD of professional etiology, is relevant and informative and allows to evaluate the activity and role of local inflammation in the development and course of the disease. With an increase in the severity of bronchial obstruction in sputum, the total number of cellular elements, neutrophils and lymphocytes increases. The feature of local inflammation developing in the initial stages of COPD of professional etiology is the predominance of macrophages in sputum. With worsening of the severity of the disease course, when the inflammation acquires a persistent character, the number of neutrophils and lymphocytes increases in sputum.
Библиографические ссылки
Basanec AV. [COPD of professional etiology: modern approaches to disease control]. Ukr. pul'monol. zhurnal. 2016;4;59-63. Ukrainian.
Levina OV, Ivchuk VV, Rubcov RV. [Practical value of determination of erythrocytic parameters in patients with COPD of professional etiology]. Svit medycyny ta biologii. 2017;4;50-53. doi: 10.26724/2079-8334-2017-4-62-50-53. Ukrainian.
Rubcov RV, Koval'chuk TA. [Chronic obstructive pulmonary disease in mining workers (etiology, prevalence): a look at the problem]. Visnyk problem biologii i medycyny. 2017;2;25-29. Russian.
Barnes PJ. Cellular and molecular mechanisms of chronic obstructive pulmonary disease. Clinics in chest medicine. 2014;35(1);71-86. doi: 10.1016/j.ccm.2013.10.004
Brightling CE, Bleecker ER, Panettieri RA. Benralizumab for chronic obstructive pulmonary disease and sputum eosinophilia: a randomised, double-blind, placebo-controlled, phase 2a study. The Lancet Respiratory Medicine. 2014;2(11);891-901. doi: 10.1016/S2213-2600(14)70187-0
Shaw JG, Vaughan A, Dent AG. Biomarkers of progression of chronic obstructive pulmonary disease (COPD). Journal of thoracic disease. 2014;6(11);1532. doi: 10.3978/j.issn.2072-1439.2014.11.33
Khurana S, Ravi A, Sutula J. Clinical characteristics and airway inflammation profile of COPD persistent sputum producers. Respiratory medicine. 2014;108(12);1761-1770. doi: 10.1016/j.rmed.2014.09.020
Iwamoto H, Gao J, Koskela J. Differences in plasma and sputum biomarkers between COPD and COPD–asthma overlap. European Respiratory Journal. 2014;(2);421-429. doi: 10.1183/09031936.00024313
Wagener AH, de Nijs SB, Lutter R. External validation of blood eosinophils, FENO and serum periostin as surrogates for sputum eosinophils in asthma. Thorax. 2014;1-6. doi: 10.1136/thoraxjnl-2014-205634
Global Strategy for the Diagnosis, Management and Prevention of COPD, Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2017;123.
Freeman CM, Crudgington S, Stolberg VR. Design of a multi-center immunophenotyping analysis of peripheral blood, sputum and bronchoalveolar lavage fluid in the Subpopulations and Intermediate Outcome Measures in COPD Study (SPIROMICS). Journal of translational medicine. 2015;13(1);19. doi: 10.1186/s12967-014-0374-z
Patel N, Belcher J, Thorpe G. Measurement of C-reactive protein, procalcitonin and neutrophil elastase in saliva of COPD patients and healthy controls: correlation to self-reported wellbeing parameters. Respiratory research. 2015;16(1);62. doi: 10.1186/s12931-015-0219-1
Singh D, Kolsum U, Brightling CE. Eosinophilic inflammation in COPD: prevalence and clinical characteristics. European Respiratory Journal. 2014;44(6);1697-1700. doi: 10.1183/09031936.00162414
Zuo L, Lucas K, Fortuna CA. Molecular regulation of toll-like receptors in asthma and COPD. Frontiers in physiology. 2015;6;312. doi: 10.3389/fphys.2015.00312
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