Influence of gel bentonite on physiological indicators of the white laboratory mice.
DOI:
https://doi.org/10.26641/2307-0404.2018.4.152924Ключевые слова:
white laboratory mice, bentonite gelАннотация
The evaluation of the effect of lifelong usage of sodium form of gel bentonite on some physiological parameters of mice (body weight, feed and water intake, general condition, change in coordination of movements, state of wool, fertility and mortality) was performed on 110 white laboratory mice (BALB / c line). This experimental study was carried out in two replicates. To accomplish this task, the mice were divided into two groups: control – the animals were on a standard diet, and experimental – they used water with the addition of sodium form of bentonite gel (0.5-1%). It was found that prolonged intake of bentonite gel by laboratory animals neither led to an excessive increase in their weight (the weight gain of the experimental group did not differ statistically significantly from the control group, p≤0.05), nor did it cause acute or chronic intoxication. It is also shown that the constant use of bentonite has a positive effect on the organism of experimental mice, which is expressed in the decrease of animal mortality, increase of life expectancy and pronounced positive effect on fertility functions (increase in the number of offspring). Based on the obtained data it can be assumed that the continuous intake of bentonite by the animal organism is one of the factors of their microbiome improvement, which affects on a plenty of physiological functions, including animals reproduction. It is possible that smectite sorbents also enrich the body of mice by certain essential mineral elements (silicon, etc.) and has cytomucoprotective properties concerning the mucous membranes of the macroorganism.
Библиографические ссылки
Dzhamaldinov ACh, Narizhnyiy AG, Kreyndlina NI. [Influence of introduction of organic silicon enterosorbents into the boar ratio on their reproductive function]. Report on “Scientific research and their practical application. Modern state and ways of development 2013 SWorld” 1-12 October 2013. Russian.
Narizhnyiy AG, Luzhnyih LYu, Eskin GV, Kropachev NA, et al. [The effect of feeding enterosorbents on the reproductive ability of pigs]. Nauk.-tehn. byul. In-tu biologiyi tvarin ta Derzh. n.-d. kontrol. In-tu vetpreparativ ta korm. dobavok. 2008;9(3):307-14. Russian.
Dyupuk ZhP, Zherom MS, Tria ZhM. [Therapeutic use of medical clays in gastroenterology]. Russian Medical Journal. 2006;1:35. Russian.
Kovalchuk NM, Lezova AA. [Gastrointestinal diseases of newborn piglets in modern conditions: recommendations].Krasnoyarsk. 2006;35. Russian.
Kuznetsov VN. [Litofagia]. Biology. 2001;5:1-8. Russian.
Murzina EA. [Substantiation of using enterosorbents in the complex therapy of chronic allergic dermatoses]. Modern drugs and technologies. 2013;2-3:50-53. Russian.
NagornayaNV, Bordugova EV, Dubova АV. [Use of enterosorbs in treatment of atopic dermatitis]. Sovremennaya pediatriya. 2005;4(9):67-70. Russian.
Yankovskyi DS, Shyrobokov VP, Dyment HS. [The method of cultivating anaerobic bacteria]. The patent for utility model number N 42906 Ukraine. А61К 35/66, А23С 9/12, С12N 1/20 – appl. 04.03.2009. Ukrainian.
Pentyuk A, Polesya T, Ilika V, Piskun R, Vershinin A, Popilov A. [Polysorb MP in the prevention and treatment of cholelithiasis and atherosclerosis]. Vrach (The Doctor). 2008;2:20-21. Russian.
Ponomarova OV, Pivnyuk VM, Nosko MM, Sakhno LA, Dekhtyar T.V., Nikolaev VG, Chekhun VF. [Prophylaxis by coal enterosorbent of acute and extended emethogenic toxicity of cancer patient chemotherapy]. Oncology. 2008;103):370-3. Ukrainian.
Tereshin VА. [Evaluation of the White Coal® enterosorbent efficacy in patients with hepatobiliary system diseases]. Herald of Pancreatic Club. 2015;3:67-72. Russian.
TomchukVA.[Enterosorbents, their properties and applications]. The Animal Biology. 2014;16(1):148-59. Ukrainian.
Frolkis VV. [Influence of enterosorption on EPR signals of different ages rats liver]. Questions of medical chemistry. 1986;32(3):80. Russian.
Frolkis VV, Muradyan HК. [Experimental ways of prolonging life]. L: Nauka; 1988. Russian.
Shyrobokov VP, Yankovskyi DS, Dyment HS. [Microbic chronicle of biosphere]. Svitohliad. 2010;5(25):18-28. Ukrainian.
Shyrobokov VP, Yankovskyi DS, Dyment HS. [At the dawn of life genesis : the role of clay minerals]. Svitohliad. 2013;1(39):58-65. Ukrainian.
Shirobokov VP, Yankovskiy DS, Dyiment GS. [Prospects of bentonite using in the creation of a new type of multiprobiotics]. Modern pediatrics. 2008;4(21):143-154. Russian.
Yankovskiy DS, Shirobokov VP, Dyiment GS. [Creation of new complex preparations based on biomass of probiotic bacteria and smectite gel]. Preventive medicine. 2013;3-4 (21):108-15. Russian.
Prasai T, Walsh K, Bhattarai S, Midmore D, Van T,MooreR, et al. Biochar, Bentonite and Zeolite Supplemented Feeding of Layer Chickens Alters Intestinal Microbiota and Reduces Campylobacter Load. PLOS ONE. 2016;11(4):e0154061.
Schulman G, Berl T, Beck G, Remuzzi G, Ritz E, Arita K, et al. Randomized Placebo-Controlled EPPIC Trials of AST-120 inCKD. Journal of the American Society of Nephrology. 2014;26(7):1732-46.
Загрузки
Как цитировать
Выпуск
Раздел
Лицензия
Copyright (c) 2018 Medicni perspektivi (Medical perspectives)
Это произведение доступно по лицензии Creative Commons «Attribution» («Атрибуция») 4.0 Всемирная.
Submitting manuscript to the journal "Medicni perspektivi" the author(s) agree with transferring copyright from the author(s) to publisher (including photos, figures, tables, etc.) editor, reproducing materials of the manuscript in the journal, Internet, translation into other languages, export and import of the issue with the author’s article, spreading without limitation of their period of validity both on the territory of Ukraine and other countries. This and other mutual duties of the author and all co-authors separately and editorial board are secured by written agreement by special form to use the article, the sample of which is presented on the site.
Author signs a written agreement and sends it to Editorial Board simultaneously with submission of the manuscript.
