Effectiveness of morphogenetic protein rhBMP-2 use in atypical third mandibular molars extraction.
DOI:
https://doi.org/10.26641/2307-0404.2020.2.206789Ключевые слова:
retention, pericoronaritis, third molars, inflammatory complicationsАннотация
Objective – improving the effectiveness of treatment of patients with retention and dystopia of the third molars of the lower jaw in their horizontal or inverse position by developing an integrated approach using photodynamic therapy and drugs that enhance osteogenesis (platelet autoplasma enriched with i-PRF fibrin and recombinant morphogenetic protein (rhBMP-2). 82 patients with difficult eruption of third molars of the lower jaw aged 19 to 37 were included in research: 40 (48.8%) men and 42 (51.2%) women. The standard approach to performing operations of atypical removal of retined third molars causes a significant number of complications (large bone defects, inflammatory contracture, post-traumatic neuritis, etc.). Treatment process was provided in two stages. During the first (preoperative) stage sanitation was done to eliminate or stabilize an acute infection which is inflammatory process in the area of impacted third molar. The second stage provides abscessed tooth extraction, wound sanitation, formed defect filling with osseo-inductive medications under the collagen membrane and complete closure. The developed surgical method for treating retention and dystopia of the lower third molars using biomaterial based on demineralized bone matrix (BCP) saturated with recombinant morphogenetic protein of bone rhBMP-2 can reduce the occurrence of postoperative inflammatory complications by 35.4%, and also reduce the time for their elimination as well.
Библиографические ссылки
Gudaryan OO, Іdashkіna NG, Nekhanevich ZhM. [Features of treatment of patients with complicated retention of the third molars at the inpatient stage]. Мedichni perspektivi. 2016;16(3):47-50. Ukrainian. doi: https://doi.org/10.26641/2307-0404.2016.3.82020
Jordanishvili AK, Korovin NV, Serikov AA, Kevlova EV. [Аnatomo-topometric jaws characteristics at crossing and retention of wisdom toothes]. The problems of dentistry. 2017;3:53-56. Russian. doi: https://doi.org/10.18481/2077-7566-2017-13-3-53-56
Khalafyan AA. [STATISTICA 6. Statistical Data Analysis . Moskva: OOO «Binom-Press»]. 2007;512s. ISBN: 978-5-9518-0215-6. Russian.
Candotto V, Oberti L, Gabrione F, Scarano A, Rossi D, Romano M. Complication in third molar extractions. J Biol Regul Homeost Agents. 2019;33(3 Suppl. 1):169-72. PMID:31538464.
Jeyaraj PE, Chakranarayan A. Soft tissue healing and bony regeneration of impacted mandibular third molar extraction sockets, following postoperative incorporation of platelet-rich fibrin. Ann Maxillofac Surg.2018;8(1):10-18. doi: https://doi.org/10.4103/ams.ams_185_17
Boda SK, Almoshari Y, Wang H, Wang X, Reinhardt RA, Duan B, Wang D, Xie J. Mineralized nanofiber segments coupled with calcium-binding BMP-2 peptides for alveolar bone regeneration. ActaBiomater. 2019;85:282-293. doi: https://doi.org/10.1016/j.actbio.2018.12.051
Kim YJ, Lee JY, Kim JE, Park JC, Shin SW, Cho KS. Ridge preservation using demineralized bone matrix gel with recombinant human bone morphogenetic protein-2 after tooth extraction: a randomized controlled clinical trial. J Oral Maxillofac Surg. 2014;72(7):1281-90. doi: https://doi.org/10.1016/j.joms.2014.01.022
Gomes-Ferreira PH, Okamoto R, Ferreira S, De Oliveira D, Momesso GA, Faverani LP. Scientific evidence on the use of recombinant human bone morphogenetic protein-2 (rhBMP-2) in oral and maxillofacial surgery. Oral Maxillofac Surg. 2016;20(3):223-32. doi: https://doi.org/10.1007/s10006-016-0563-4
Steed MB. The indications for third-molar extractions. J Am Dent Assoc. 2014;145(6):570-3. doi: https://doi.org/10.14219/jada.2014.18
Graziani F, D'Aiuto F, Gennai S, Petrini M, Nisi M, Cirigliano N, Landini L, Bruno RM, Taddei S, Ghiadoni L. Systemic inflammation after third molar removal: A Case-Control Study. J Dent Res. 2017;96(13):1505-12. doi: https://doi.org/10.1177/0022034517722775
Meimandi M, Talebi Ardakani R, Esmaeil Nejad A, Yousefnejad P, Saebi K, Tayeed MH. The effect of photodynamic therapy in the treatment of chronic periodontitis: A Review of Literature. J Lasers Med Sci. 2017;8(Suppl 1):S7-S11. doi: https://doi.org/10.15171/jlms.2017.s2
Schorn L, Sproll C, Ommerborn M, Naujoks C, Kübler NR, Depprich R. Vertical bone regeneration using rhBMP-2 and VEGF. Head Face Med. 2017;13(1):11. doi: https://doi.org/10.1186/s13005-017-0146-0
Загрузки
Как цитировать
Выпуск
Раздел
Лицензия
Copyright (c) 2020 Medicni perspektivi (Medical perspectives)
Это произведение доступно по лицензии Creative Commons «Attribution» («Атрибуция») 4.0 Всемирная.
Submitting manuscript to the journal "Medicni perspektivi" the author(s) agree with transferring copyright from the author(s) to publisher (including photos, figures, tables, etc.) editor, reproducing materials of the manuscript in the journal, Internet, translation into other languages, export and import of the issue with the author’s article, spreading without limitation of their period of validity both on the territory of Ukraine and other countries. This and other mutual duties of the author and all co-authors separately and editorial board are secured by written agreement by special form to use the article, the sample of which is presented on the site.
Author signs a written agreement and sends it to Editorial Board simultaneously with submission of the manuscript.
