Hemodynamics, functional state of endothelium and renal function, platelets depending on the body mass index in patients with chronic heart failure and preserved systolic function.
DOI:
https://doi.org/10.26641/2307-0404.2014.1.24413Ключевые слова:
chronic heart failure, hemodynamics, endothelium, platelets, body mass indexАннотация
The aim of the study was to evaluate hemodynamics, endothelium function of kidneys and platelets depending on the body mass index (BMI) in patients with chronic heart failure (CHF) and preserved systolic function. 42 patients (mean age - 76,69±0,83 years) with CHF II-III FC NYHA with preserved systolic function (LVEF>45%) were enrolled. Echocardiography was performed, endothelial function, serum creatinine levels and microalbuminuria were determined in patients. BMI and glomerulation filtration rate were calculated by formulas. The morphological and functional status of platelets was estimated by electronic microscopy. It was defined that increased BMI in patients with CHF and preserved systolic function determines the structural and functional changes of the myocardium and leads to the endothelial and renal functional changes. An increased risk of thrombogenesis was established in patients with overweight and obesity.
Библиографические ссылки
Бильченко А.В. Артериальная гипертензия в различных клинических ситуациях / А.В. Бильченко, Г.В. Дзяк – Харьков: ЧПИ «Новое слово», 2012. – 196 с.
Коркушко О.В. Тромбоциты: физиология, мор¬фо¬логия, возрастные и патологические осо¬бен¬ности, антитромбоцитарная терапия / О.В. Коркушко, В.Ю. Лишневская. – К.: Медкнига, 2011. – 240 с.
Курята О.В. Ліпідний обмін і кардіовас¬куляр¬ний ризик у хворих на хронічну хворобу нирок: мо¬нографія / О.В. Курята, Є.О. Фролова; Дніпропетр. мед. акад. МОЗ України. – Дніпропетровськ : Герда, 2013. – 112с.
Курята О.В. Хронічна серцева недостатність зі збереженою систолічною функцією: особливості мор¬фо¬функціонального стану тромбоцитів та їх зміни під впливом лікування / О.В. Курята, Ю.С. Кушнір // Ме¬дицина неотложных состояний. – 2013. – № 6 (53). – С. 113-118.
Перцева Н.О. Кількісна ультраструктурна ха¬рак¬теристика тромбоцитів у хворих на цукровий діабет 2-го типу у фазі компенсації з артеріальною гі¬пертонією за умов корекції артеріального тиску лозар¬таном / Н.О. Перцева // Морфологія. – 2011. – T.V, № 4. – С. 37-44.
Про затвердження протоколів надання медич¬ної допомоги за спеціальністю «Кардіологія»: Наказ МОЗ України від 03.07.2006 № 436. – Режим доступу: www.moz.gov.ua.
Ратманова А. Сердечно-сосудистая заболевае¬мость и смертность - статистика по европейским стра¬нам (2008) / А. Ратманова // Medicine rewiew. – 2009. – № 1 (6). – С. 6–12.
Реброва О. Ю. Статистический анализ меди¬цинских данных. Применение пакета прикладных программ STATISTICA / О.Ю. Реброва. – М.: Медиа Сфера, 2002. – 312 с.
Рекомендації Асоціації кардіологів України з лікування хронічної серцевої недостатності у дорос¬лих (перегляд 2011) / Л.Г. Воронков, К.М. Амосова, А.Е. Багрій [та ін.] // Серцева недостатність. – 2011. – № 1. – С. 101-116.
Association of bodyweight with total mortality and with cardiovascular events in coronary artery disease: a systematic review of cohort studies / A. Romero-Corral, V. Mo¬n¬tori [et al.] // Lancet.–2006. – Vol. 368. – P. 666-678.
Celermajer D. S. Endothelial dysfunction: does it matter? It is relevant? / D. S. Celermajer // J. Am. Coll. Cardiology. – 1997. – Vol. 30. – P. 325–333.
Doehner W. The obesity paradox: weighing the benefit / W. Doehner, A. Clark, S. Anker // Eur. Heart J. – 2010. – Vol. 31, N 2. – P. 146-148.
Prognosis of heart failure with preserved ejection fraction: a 5 year prospective population-based study / C. Tri¬bouilloy, D. Rusinaru [et al.] // Eur. Heart J. – 2008. – Vol. 28, N 3. – P. 339-347.
The influence of body mass index on mortality and bleeding among patients with or at high-risk of athe¬rothrombotic disease / K. Mak, D. Bhatt [et al.] // Eur. Heart J. – 2009. – Vol. 30, N 7. – P. 857-865.
The Task Force for the diagnosis and treatment of Chronic Heart Failure of the European Society of Car¬diology. Guidelines for the diagnosis and treatment of Chronic Heart Failure: full text (update 2005) // Eur. Heart J. – 2005. – Vol. 7. – P. 1–45.
Bil'chenko AV, Dzyak GV. [Arterial hypertension in the various clinical situations]. Khar'kov: ChPI «Novoe slovo»; 2012. Russian.
Korkushko OV, Lishnevskaya VYu. [Platelets: phy¬siology, morphology, age and pathological features, antiplatelet therapy]. Kiev: Medkniga; 2011. Russian.
Kuryata OV, Frolova ЄO. [Lipid metabolism and cardiovascular risk in patients with chronic kidney di¬sease]. Dnіpropetrovs'k: Gerda; 2013. Ukrainian.
Kuryata OV, Kushnіr YuS. [Chronic heart failure with preserved systolic function: the feartures of mo¬r¬phological and functional status of platelets and their changes under the influence of the treatment]. Meditsina neotlozhnykh sostoyaniy. 2013;6(53):113-8. Ukrainian.
Pertseva NO. [Quantitative ultrastructural cha¬racteristics of platelets in the patients with diabetes mellitus type 2 in a compensation with arterial hyper¬tension under correction of arterial blood pressure with losartan]. Morphologіya. 2011;5(4):37-44. Ukrainian.
[On approval of the protocols of medical care in Cardiology. Order of HM of Ukraine from 03.07.2006 N 436]. Available from: http://www.moz.gov.ua. Uk¬rainian.
Ratmanova A. [Cardiovascular morbidity and mor¬tality - statistics of the European countries (2008)]. Medicine rewiew. 2009;1(6):6–12. Russian.
Rebrova OYu. [Statistical analysis of medical data. The use of the application package STATISTICA]. Media Sfera; 2002. Russian.
Voronkov LG, Amosova KM, Bagriy AE. [Re¬commendations of the Association of Cardiologists of Ukraine for the treatment of chronic heart failure in adults (view 2011)]. Sertseva nedostatnіst'. 2011;1:101-16. Ukrainian.
Romero-Corral A, Montori A. Association of bodyweight with total mortality and with cardiovascular events in coronary artery disease: a systematic review of cohort studies. Lancet. 2006;368:666-78.
Celermajer DS. Endothelial dysfunction: does it matter? It is relevant? J. Am. Coll. Cardiology. 1997;30:325–33.
Doehner W, Clark A, Anker S. The obesity pa¬ra¬dox: weighing the benefit. Eur. Heart J. 2010;31(2):146-8.
Tribouilloy C, Rusinaru D. Prognosis of heart failure with preserved ejection fraction: a 5 year pros¬pec¬tive population-based study. Eur. Heart J. 2008;28(3):339-47.
Mak K, Bhatt D. The influence of body mass index on mortality and bleeding among patients with or at high-risk of atherothrombotic disease. Eur. Heart J. 2009;30(7):857-65.
The Task Force for the diagnosis and treatment of Chronic Heart Failure of the European Society of Car¬diology. Guidelines for the diagnosis and treatment of Chronic Heart Failure: full text (update 2005). Eur. Heart J. 2005;7:1–45.
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