Morphological, spectral and toxicological features of new composite material of titanium nanodioxide with nanosilver for use in medicine and biology

Авторы

  • M.M. Zahornyi Frantsevich Institute of Problems of Materials Science, NAS of Ukraine, Krzhizhanovskoho str., 3, Kyiv, 03142; LLC «Nanotechcenter», Krzhizhanovskoho str., 3, Kyiv, 03680, Ukraine https://orcid.org/0000-0003-2443-8050
  • O.P. Yavorovsky Bogomolets National Medical University, T. Shevchenko вlvd., 13, Kyiv, 01601, Ukraine https://orcid.org/0000-0002-4573-8039
  • V.M. Riabovol Bogomolets National Medical University, T. Shevchenko вlvd., 13, Kyiv, 01601, Ukraine https://orcid.org/0000-0002-1582-7188
  • N.I. Tyschenko Frantsevich Institute of Problems of Materials Science, NAS of Ukraine, Krzhizhanovskoho str., 3, Kyiv, 03142; LLC «Nanotechcenter», Krzhizhanovskoho str., 3, Kyiv, 03680, Ukraine https://orcid.org/0000-0001-6714-121X
  • T.F. Lobunets Frantsevich Institute of Problems of Materials Science, NAS of Ukraine, Krzhizhanovskoho str., 3, Kyiv, 03142; LLC «Nanotechcenter», Krzhizhanovskoho str., 3, Kyiv, 03680, Ukraine https://orcid.org/0000-0002-9552-9163
  • T.V. Tomila Frantsevich Institute of Problems of Materials Science, NAS of Ukraine, Krzhizhanovskoho str., 3, Kyiv, 03142, Ukraine
  • O.V. Shirokov Frantsevich Institute of Problems of Materials Science, NAS of Ukraine, Krzhizhanovskoho str., 3, Kyiv, 03142, Ukraine https://orcid.org/0000-0002-0680-0370
  • A.V. Ragulya Frantsevich Institute of Problems of Materials Science, NAS of Ukraine, Krzhizhanovskoho str., 3, Kyiv, 03142; LLC «Nanotechcenter», Krzhizhanovskoho str., 3, Kyiv, 03680, Ukraine https://orcid.org/0000-0002-0859-0004
  • Ye.M. Anisimov Bogomolets National Medical University, T. Shevchenko вlvd., 13, Kyiv, 01601, Ukraine https://orcid.org/0000-0001-6822-5212

DOI:

https://doi.org/10.26641/2307-0404.2022.1.254381

Ключевые слова:

nanostructures, surface defects, titanium nanodioxide composite with nanosilver, titanium dioxide nanopowder, acute intraperitoneal toxicity, sensitizing effect, biological activity, anatase

Аннотация

The results of this study indicate that titanium dioxide nanoparticles (nano-TiO2) possess adsorptive, photocatalytic, bactericidal, virucidal and fungicidal properties, which are used in antibacterial coating, for air and water disinfection. In parallel with studies of the physicochemical characteristics of titanium dioxide, its toxicological assessment was carried out to prevent possible harmful effects on humans and the biosphere objects, followed by an assessment of the nano-TiO2 hazard class. To enhance these useful properties of nano-TiO2, nanopowders of titanium dioxide and a composite of titanium dioxide were synthesized with a silver (nano-TiO2 /Ag) by way of chemical precipitation of metatitanic acid adding silver nitrate to the composite at 500-600°C.  It was stated that the synthesized nanostructures have the following characteristics: anatase crystal structure of TiO2 (anatase, rutile, brookite – natural crystalline modifications of TiO2), the size of Ag nanoparticles is 35-40 nm, TiO2 – 13-20 nm. Nanocomposite has surface defects of the crystal lattice (oxygen vacancies, impurities, excess electrons or holes), silver nanoparticles are localized on the surface of anatase TiO2, which increases adsorptive, photocatalytic, biological and specifically antibacterial properties of the composite material nano-TiO2/Ag. According to the parameters of acute intraperitoneal toxicity, the studied nanocomposite anatase nano-TiO2/Ag was classified as a moderately dangerous substance (material). Nano-TiO2 and TiO2/Ag nanocomposites do not cause local irritation to the skin, yet have a mildly irritating effect on the mucous membrane of the eye, and are also characterized by a weak sensitization effect.

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Загрузки

Опубликован

2022-03-30

Как цитировать

1.
Zahornyi M, Yavorovsky O, Riabovol V, Tyschenko N, Lobunets T, Tomila T, Shirokov O, Ragulya A, Anisimov Y. Morphological, spectral and toxicological features of new composite material of titanium nanodioxide with nanosilver for use in medicine and biology. Med. perspekt. [Интернет]. 30 март 2022 г. [цитируется по 12 декабрь 2024 г.];27(1):152-9. доступно на: https://journals.uran.ua/index.php/2307-0404/article/view/254381

Выпуск

Том 27 № 1 (2022)

Раздел

PREVENTIVE MEDICINE

Лицензия

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