The effect of yoga practice on lipid profiles in patients with chronic heart failure

T.M. Babkina; G.S.  Smyrnova; L.A.  Mykhailenko; T.M.  Kozarenko; M.V.  Globa; V.V.  Kundina

doi:10.26641/2307-0404.2022.2.260241

Авторы

T.M. Babkina Shupyk National Healthcare University of Ukraine, Dorohozhytska str., 9, Kyiv, 04112, Ukraine https://orcid.org/0000-0001-5046-870X
G.S. Smyrnova Shupyk National Healthcare University of Ukraine, Dorohozhytska str., 9, Kyiv, 04112, Ukraine http://orcid.org/0000-0001-8788-7975
L.A. Mykhailenko Shupyk National Healthcare University of Ukraine, Dorohozhytska str., 9, Kyiv, 04112, Ukraine
T.M. Kozarenko Shupyk National Healthcare University of Ukraine, Dorohozhytska str., 9, Kyiv, 04112, Ukraine
M.V. Globa Shupyk National Healthcare University of Ukraine, Dorohozhytska str., 9, Kyiv, 04112, Ukraine
V.V. Kundina Shupyk National Healthcare University of Ukraine, Dorohozhytska str., 9, Kyiv, 04112, Ukraine

DOI:

https://doi.org/10.26641/2307-0404.2022.2.260241

Ключевые слова:

heart failure, dyslipidemia, yoga, full yogic breathing

Аннотация

The aim of the present study was to assess the efficiency of yoga practice in addition to the standard medical therapy in patients with chronic heart failure (HF) and dyslipidemia. One hundred and two patients with chronic HF and dyslipidemia were divided into the control group (CG) – 54 patients and the yoga group (YG) – 48 patients. The CG was prescribed standard therapy for chronic HF (angiotensin converting enzyme inhibitors, β-blockers, aldosterone antagonists, digoxin, loop diuretics, statins, antiplatelet agents) and dyslipidemia. The YG additionally followed lifestyle modification in the form of 1 h daily practice of yoga for a period of 3 months. All patients completed the questionnaire reporting on their age, gender, medical history and treatment. The fasting blood samples were analyzed for total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol, C-reactive protein, interleukin-8 and tumor necrosis factor -α on admission to the department and after 3 months of treatment. The pre-specified duration of the enrollment period was two years and during that time we interviewed 168 patients. Forty-two did not meet the inclusion criteria for the study, 24 patients refused to participate. A total of 102 patients were enrolled, of them, 54 were included into the control group and 48 into the yoga group. At baseline, there were no significant (p>0.05) differences between the groups in clinical characteristics of the patients. On admission to hospital the patients of both groups received standard therapy in comparable doses. By the end of the study, a significant (p<0.05) reduction in TC, TG and LDL-C levels was observed in both groups with a tendency to more considerable changes in YG. Correlation analysis revealed the positive correlation relationship between TC, LDL-C levels and cytokines. The present study has shown that the practice of yoga in addition to the standard therapy in patients with HF and dyslipidemia could be associated with lipid profile improvements.

Библиографические ссылки

Antomonov MYu. [Mathematical processing and analysis of biomedical data. 2nd edition]. Kyiv: MIC "Medinform"; 2017. p. 579. Russian.

Amin MN, Siddiqui SA, Ibrahim M, et al. Inflammatory cytokines in the pathogenesis of cardio-vascular disease and cancer. SAGE Open Medicine. 2020 January. doi: https://doi.org/10.1177/2050312120965752

Azami M, Hafezi Ahmadi MR, Yekta Koosha-li MH, et al. Effect of Yoga on Lipid Profile and C-reactive Protein in Women. Int J Prev Med. 2019;10:81. doi: https://doi.org/10.4103/ijpvm.IJPVM_487_17

Bonsu KO, Owusu IK, Buabeng KO, et al. Statin treatment and clinical outcomes of heart failure among Africans: an inverse probability treatment weighted analysis. J Am Heart Assoc. 2017;6(4):e004706. doi: https://doi.org/10.1161/JAHA.116.004706

Halldin A, Lissner L, Lernfelt B, et al. Cholesterol and triglyceride levels in midlife and risk of heart failure in women, a longitudinal study: the prospective population study of women in Gothenburg. BMJ Open. 2020;10:e036709. doi: https://doi.org/10.1136/bmjopen-2019-036709

Hedayatnia M, Asadi Z, Zare-Feyzabadi R, et al. Dyslipidemia and cardiovascular disease risk among the MASHAD study population. Lipids Health Dis. 2020;19:42. doi: https://doi.org/10.1186/s12944-020-01204-y

Lesyuk W, Kriza C, Kolominsky-Rabas P. Cost-of-illness studies in heart failure: a systematic review 2004-2016. BMC Cardiovascular Disorders. 2018;18(74):1-11. doi: https://doi.org/10.1186/s12872-018-0815-3

Levine B, Kalman J, Mayer L, et al. Elevated circulating levels of tumor necrosis factor in severe chronic heart failure. N Engl J Med. 1990;323:23641. doi: https://doi.org/10.1056/NEJM199007263230405

Li Li-Hua, Dutkiewicz EP, Huang Ying-Chen, et al. Analytical methods for cholesterol quantification. Journal of Food and Drug Analysis. 2019;27:375-86. doi: https://doi.org/10.1016/j.jfda.2018.09.001

Moutachakkir M, Lamrani Hanchi A, Baraou A, et al. Immunoanalytical characteristics of C-reactive protein and high sensitivity C-reactive protein. Ann Biol Clin (Paris). 2017;75(2):225-9. doi: https://doi.org/10.1684/abc.2017.1232

Stephens I. Medical yoga therapy. Children (Basel). 2017;4(2):12. doi: https://doi.org/10.3390/children4020012

Strassheim D, Dempsey E, Gerasimovskaya E, et al. Role of Inflammatory Cell Subtypes in Heart Failure. Journal of Immunology Research. 2019;(3):1-9. doi: https://doi.org/10.1155/2019/2164017

Tsoupras A, Lordan R, Zabetakis I. Inflammation, not cholesterol, is a cause of chronic disease. Nutrients. 2018;10(5):604. doi: https://doi.org/10.3390/nu10050604

Zhang Y, Vittinghoff E, Pletcher MJ, et al. Associations of blood pressure and cholesterol levels during young adulthood with later cardiovascular events. JACC. 2019;74(3):330-41. doi: https://doi.org/10.1016/j.jacc