Ways to promote the efficiency of herpetic stomatitis treatment

R.V.  Lutsenko; N.V.  Moisieieva; A.H.  Sydorenko; H.Yu.  Ostrovska; A.A.  Kapustianska

doi:10.26641/2307-0404.2023.2.283255

Авторы

R.V. Lutsenko Poltava state medical university, Shevchenko str., 23, Poltava, 36011, Ukraine https://orcid.org/0000-0003-0277-0458
N.V. Moisieieva Poltava state medical university, Shevchenko str., 23, Poltava, 36011, Ukraine https://orcid.org/0000-0002-5511-2988
A.H. Sydorenko Poltava state medical university, Shevchenko str., 23, Poltava, 36011, Ukraine https://orcid.org/0000-0002-9853-5892
H.Yu. Ostrovska Poltava state medical university, Shevchenko str., 23, Poltava, 36011, Ukraine https://orcid.org/0000-0002-3132-3537
A.A. Kapustianska Poltava state medical university, Shevchenko str., 23, Poltava, 36011, Ukraine https://orcid.org/0000-0001-9150-8472

DOI:

https://doi.org/10.26641/2307-0404.2023.2.283255

Ключевые слова:

herpes simplex virus, herpetic stomatitis, inosine pranobex, combination therapy, immunological parameters

Аннотация

The treatment of herpetic stomatitis should be etiotropic, pathogenetic, symptomatic, and local. The research determined the effectiveness of inosine pranobex (1000 mg 4 times a day) in herpetic stomatitis treatment. Addition of inosine pranobex to the pharmacotherapy of herpetic stomatitis reduced hospital stay and duration of treatment. The drug suppresses the synthesis of the virus due to the structure of inosinic acid in the polyribosomes of the cell affected by the virus, and also helps to eliminate the deficiency or dysfunction of immunity that occurred in the case of herpetic stomatitis, it affects the activity of T-cytotoxic lymphocytes and natural killers, enhances the action of neutrophil granulocytes, chemotaxis and phagocytosis of monocytes and macrophages, increases the synthesis of interleukins IL-1 and IL-2, affects the number of Ig G immunoglobulins. Applying inosine pranobex also significantly decreased pain syndrome manifestations from the start of the treatment. It contributed to body temperature normalization 2 days earlier which shortened the treatment period at the in-patient department. Applying inosine pranobex in the combination therapy of herpetic stomatitis has shown a potent clinical efficacy and can be an alternatіve to acyclic nucleosides in patients with herpetic stomatitis of the oral mucosa.

Библиографические ссылки

Bida AV, Romanova YuH. [Indicators of immunological markers of blood serum and the level of mineral metabolism of oral fluid in patients with chronic herpes infection in the evaluation of the treatment and prevention complex during dental implantation]. Actual problems of modern medicine: Herald of the Ukrainian Medical Stomatological Academy. 2018;18(1):217-21. Ukrainian.

Bondarenko HM, Shcherbakova YuV, Chyrva VB, Teslenko SV. [Ultrashort treatment regimen for recurrence of genital herpes using pathogenetic agents]. Dermatolohiia ta venerolohiia. 2019;4:12-4. Ukrainian. doi: https://doi.org/10.33743/2308-1066-2019-4-12-17

Horai MA, Kurdysh LF, Popova OI, Kotelmach OI. [Efficient improvements of herpex simplex la-bialis treatment using diode laser and “tebodont” gel]. Ukrainskyi stomatolohichnyi almanakh. 2018;1:21-3. Ukrainian. doi: https://doi.org/10.31718/2409-0255.1.2018.05

Hryshakova AM, Chaban TV, Skyba VYa. [Clinical effectiveness of treatment of acute herpetic stomatitis in children]. Journal of dentistry. 2017;3:49-52. Ukrainian.

Dronyk I. [Current issues of treatment of herpetic infection at a doctor's office]. The scientific heritage. 2020;47:7-8. Ukrainian.

Kravchun PH, Babadzhan VD, Miasoiedov VV, editors. [Methodology of scientific research in medicine]. Kharkiv: KhSMU; 2020. p. 260. Ukrainian.

Kramarov SO, Yevtushenko VV. [Modern approaches to the treatment of herpetic infection in children]. Aktualna infektolohiia. 2021;7:144-9. Ukrainian. doi: https://doi.org/10.22141/2312-413x.7.3.2019.170993

Nikolyshyna YeV, Bublii TD. [Prospects of improving treatment of HSV infected at the dentist’s]. Ukrainskyi stomatolohichnyi almanakh. 2018;2:30-2. Ukrainian.

Khodak LA, Ohiienko VI, Khodak AS. [Difficulties with the diagnosis of pain syndrome in a 16-year-old patient with herpes zoster (clinical case)]. Aktualna infektolohiia. 2021;7(3):172-4. Ukrainian. doi: https://doi.org/10.22141/2312-413x.7.3.2019.170999

Abaturov A, Nikulina A, Tokareva N. Effect of treatment with inosine pranobex in acute respiratory viral infections in children. Child`s health. 2021;13(5):490-4. doi: https://doi.org/10.22141/2224-0551.13.5.2018.141565

Avetikov DS, Bukhanchenko OP, Ivanytskyi IO, Aipert VV, Steblovskyi DV. Perspectives for applying the additional study methods for diagnostics optimization of postoperative hypertrophic scars of the head and neck. Wiadomosci lekarskie. 2018;71(3):470-3.

Cole S. Herpes simplex virus: epidemiology, diagnosis, and treatment. Nursing Clinics of North America. 2020;3(55):337-45. doi: https://doi.org/10.1016/j.cnur.2020.05.004

Edgar NR, Saleh D, Miller RA. Recurrent aphthous stomatitis: a review. J Clin Aesthet Dermatol. 2017;10(3):26-36.

Horbal N. Peculiarities of immunological parameters in patients with recurrent herpes simplex virus infection. Proceedings of the Shevchenko Scientific Society. Medical Sciences. 2019;2(57):128-32. doi: https://doi.org/10.25040/ntsh2019.02.13

Kłysik K, Pietraszek A, Karewicz A, Nowakowska M. Acyclovir in the Treatment of Herpes Viruses - A Review. Curr Med Chem. 2020;27(24):4118-37. doi: https://doi.org/10.2174/0929867325666180309105519

Petti S, Lodi G. The controversial natural history of oral herpes simplex virus type 1 infection. Oral Dis. 2019;25(8):1850-65. doi: https://doi.org/10.1111/odi.13234

Petrushanko T, Chereda V, Loban G. The relationship between colonization resistance of the oral cavity and individual-typological characteristics of personality: dental aspects. Wiadomosci lekarskie. 2017;70(4):754-7.

Zhu S, Viejo-Borbolla A. Pathogenesis and virulence of herpes simplex virus. Virulence. 2021;1(12):2670-702. doi: https://doi.org/10.1080/21505594.2021.1982373