Inhibitory mechanism of influence of thyroid hormones on cognitive function of the brain.

Автор(и)

  • A. G. Rodynsky
  • E. M. Demchenko
  • E. J. Kondratieva
  • A. J. Golubka
  • D. S. Yaroshenko

DOI:

https://doi.org/10.26641/2307-0404.2017.2.109709

Ключові слова:

hyperthyroidism, hypothyroidism, CNS, GABA, unsaturated fatty acids, hippocampus

Анотація

In experiments on young rats there were stu­died changes in the fatty acid spectrum of fraction of  free fatty acids (FFA) of neocortex and hippocampus in con­ditions of thyroid dysfunction. Elevated levels of thyroid hormones caused accumulation of polyunsaturated linoleic and linolenic acids in the neocortex by 2 times, in the hippocampus – by 52%. State of hypo­thyroidism also contributed to the increase of C18: 2,3 in the neocortex by 74.4%. Growth of share of unsaturated fatty acid fraction in the content of fatty acid spectrum of neocortex also was accompanied by decrease in saturated C16:0 and C21:0 by 25% and 36% res­pectively. Increase of the level of unsaturated fatty acids fraction of the cerebral cortex is possibly associated with the decrease in "unsaturation" structure of lipids, which in its turn may enhance serotonergic synaptic activity. Research of concentration of neuromediator amino acids in neocortex showed increase of serotonin content both in conditions of hyperthyroidism and hypothyroidism. In conditions of hyperthyroidism increased content of GABA was observed. Activity of serotonin- and GABA- ergic neurotransmitter systems of the brain in conditions of hyperthyroidism can be considered as increase of inhibitory processes in the  effect of feedback. In conditions of experimental hypothyroidism activation of the inhibitory effects of CNS serotonergic system may be one of the ways to reduce the metabolism.

Біографії авторів

A. G. Rodynsky

SE «Dnipropetrovsk medical academy of Health Ministry of Ukraine»
Department or Physiology
Vernadsky str., 9, Dnipro, 49044, Ukraine

E. M. Demchenko

SE «Dnipropetrovsk medical academy of Health Ministry of Ukraine»
Department or Physiology
Vernadsky str., 9, Dnipro, 49044, Ukraine

E. J. Kondratieva

SE «Dnipropetrovsk medical academy of Health Ministry of Ukraine»
Department or Physiology
Vernadsky str., 9, Dnipro, 49044, Ukraine

A. J. Golubka

SE «Dnipropetrovsk medical academy of Health Ministry of Ukraine»
Department or Physiology
Vernadsky str., 9, Dnipro, 49044, Ukraine

D. S. Yaroshenko

SE «Dnipropetrovsk medical academy of Health Ministry of Ukraine»
Department or Physiology
Vernadsky str., 9, Dnipro, 49044, Ukraine

Посилання

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Опубліковано

2017-06-29

Як цитувати

1.
Rodynsky AG, Demchenko EM, Kondratieva EJ, Golubka AJ, Yaroshenko DS. Inhibitory mechanism of influence of thyroid hormones on cognitive function of the brain. Med. perspekt. [інтернет]. 29, Червень 2017 [цит. за 24, Листопад 2024];22(2):9-13. доступний у: https://journals.uran.ua/index.php/2307-0404/article/view/109709

Номер

Том 22 № 2 (2017)

Розділ

ТЕОРЕТИЧНА МЕДИЦИНА

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