Assessment of functional tests on determining resistance of respiratory tract in patients with bronchial asthma, COPD and their combination.

Автор(и)

  • K. V. Nazarenko
  • S. G. Opimakh
  • M. O. Polianskaja

DOI:

https://doi.org/10.26641/2307-0404.2017.3.111929

Ключові слова:

asthma, COPD, asthma-COPD overlap, airway resistance

Анотація

The mechanical properties of the respiratory tract (including airway resistance) is an important indicator of pulmonary function, and definition of resistance is used to diagnose and monitor obstructive lung diseases. This study was performed in order to evaluate and compare functional results of tests to determine the resistance of the airways in patients with asthma, chronic obstructive pulmonary disease and their combination. The study involved 191 patients: with asthma (n=34), with COPD (n=17) and their combination (n=140). Patients underwent bodyplethysmography and impulse oscillometry. A statistically significant correlation of medium strength between parameters of the total resistance, determined with the help of bodyplethysmography and impulse oscillometry, r=0.57, p<0.001. According to ROC-analysis, the best point of distribution of normal and pathological parameters of impulse oscillometry (R5Hz) as a diagnosis of increased respiratory resistance is 130% and higher from the proper values. The area under the ROC curve is 0.807. When interpreting the results of impulse oscillometry in patients with asthma, COPD and their combination, R5Hz level equal to or exceeding 130% of the proper values is proposed to be regarded as a sign of an increased respiratory resistance with sensitivity of technique – 64.0%, specificity – 87.5% and prognostic value of the positive result - 98.2%. 

Біографії авторів

K. V. Nazarenko

SO «National institute of phthysiology and pulmonology
named after F.G. Ianovsky NAMS of Ukraine»
Pulmonology department *

S. G. Opimakh

Amosova str. 10, Kyiv, 03680, Ukraine
Diagnostics, therapy and clinical pharmacology department **
Amosova str. 10, Kyiv, 03680, Ukraine

M. O. Polianskaja

Amosova str. 10, Kyiv, 03680, Ukraine
Diagnostics, therapy and clinical pharmacology department **
Amosova str. 10, Kyiv, 03680, Ukraine

Посилання

1. Vlasov VV. [Study of diagnostic methods]. Mezh­dunarodnyiy zhurnal meditsinskoy praktiki. 2006;4:7–17. Russian.

2. Lapach SN, Chubenko AV, Babich PN. [Sta­tistical methods in biomedical research using Excel]. Kyiv, Morion. 2000;320. Russian.

3. Moskalenko VF, Puzanova OG. [Methodology of diagnosis and evidence, or evidence-based diagnosis]. Therapia. Ukrainskiy medichniy visnik. 2011;6:20–26. Ukrainian.

4. Crie´e CP, Sorichter S, Smith HJ. Body plethys­mography – Its principles and clinical use. Respiratory Medicine. 2011;105:959-71.

5. Desiraju K, Agrawal A. Impulse oscillometry: The state-of-art for lung function testing. Lung India. 2016;33(4):410-6.

6. Goldman MD, Smith HJ, Ulmer WT. Whole-body plethysmography. Eur. Respir. Mon. 2005;31:15-43.

7. Hayden SR, Brown MD. Likelihood ratio: a powerful tool for incorporating the results of a diagnostic test into clinical decision making. Ann. Emerg. Med. 1999;33:575-80.

8. Bickel S, Popler J, Lesnick B, Eid N. Impulse oscillometry: interpretation and practical applications. Chest. 2014;146(3):841-7.

9. Pellegrino R, Viegi G, Brusasco V. Interpretative strategies for lung function tests. Eur. Respir. J. 2005;26:948-68.

10. Lalkhen AG, McCluskey A. Clinical tests: sen­sitivity and specificity. Continuing Education in Anaes­thesia, Critical Care & Pain. 2008;8(6):221-3.

11. Wang N, Zeng NN, Zhu W. Sensitivity, Speci­ficity, Accuracy, Associated Confidence Interval And ROC Analysis With Practical SAS Implementations. Health Care and Life Sciences. 2010;14:32-39.

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Як цитувати

1.
Nazarenko KV, Opimakh SG, Polianskaja MO. Assessment of functional tests on determining resistance of respiratory tract in patients with bronchial asthma, COPD and their combination. Med. perspekt. [інтернет]. 12, Жовтень 2017 [цит. за 23, Листопад 2024];22(3):73-81. доступний у: https://journals.uran.ua/index.php/2307-0404/article/view/111929

Номер

Том 22 № 3 (2017)

Розділ

КЛІНІЧНА МЕДИЦИНА

Ліцензія

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