New aspects of non-invasive diagnosis of intestinal pathology.
DOI:
https://doi.org/10.26641/2307-0404.2018.1(part2).126948Ключові слова:
inflammatory bowel disease, ulcerative colitis, Crohn's disease, irritable bowel syndrome, differential diagnosis, fecal calprotectinАнотація
A comparative assessment of fecal calprotectin (FC) levels was performed in 160 patients with chronic inflammatory bowel disease (CIBD) (Crohn's disease (CD), ulcerative colitis (UC)) and irritable bowel syndrome (IBS). The results of FC in patients with CIBD and IBS were compared with the values of FC of 31 healthy patients (control group). The mean FC level in patients with CIBD was 65.75 μg/g compared to the control group (13.72 μg/g) (p<0.05). In the group of patients with IBS, the FC level was 16.18 μg/g (p≥0.05). Significant correlation was found between the levels of FC with CIBD and FC with IBS (p<0.05). The obtained results confirmed the high diagnostic value of the method of determining fecal calprotectin in the differential diagnosis of functional and inflammatory bowel diseases.
Посилання
Stepanov JuM,FedorovaNS. [The comparative content of fecal calprotectin in patients with chronic inflammatory bowel diseases and functional pathology of the colon]. Dnіpropetrovsk, Gastroenterologіya. 2010;401-6. Russian.
Stepanov JuM,FedorovaNS. [Realities and perspectives in the diagnosis of bowel diseases]. Suchasna gastroenterologіya. 2010;1(51):109-13. Russian.
FedorovaNS, Khanyukov AA. [Opportunities and prospects in the diagnosis of functional bowel disease]. Zdorov'e rebenka. 2017;12(2.1). Russian.
Carroccio A, Jacono G, Cottone М. Diagnostic Accuracy of Fecal calprotectin assay in distinguishing organic causes of chronic diarrhea from irritable bowel syndrome: a prospective study in adults and children. Clinical Chemistry. 2003;49:861-7.
Longstresh GF, Thompson WG, Chey WD, et al. Functional bowel disorders. Gastroenterology. 2006;130(5):1480-91.
Lorens-Meyer H. Inflammatory bowel disease. Laboratory Diagnostics. 2001;40.
Natalie E, Roy A. Sherwood Walsham Fecal calprotectin in inflammatory bowel disease. Clin Exp Gastroenterol. 2016;9:21-29.
Faecal calprotectin diagnostic tests for inflammatory diseases of the bowel / National Institute for Health and Clinical Excellence. NICE diagnostic guideline 11.LondonUK; 2013.
Tibble J, Sigthorsson G, Bridger S. Use of surrogate markers of inflammation andRomecriteria to distinguish organic from nonorganic intestinal disease. Gastroenterology. 2002;123:450-60.
Tibble J, Sigthorsson G, Bridger S. Surrogate markers of intestinal inflammation are predictive of relapse in patients with inflammatory bowel disease. Gastroenterology. 2000;119:15-22.
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