Features of the local immunity state of upper respiratory tract mucosa in children – pupil-orphans of children’s home and effectiveness of seasonal prophylaxis of ARVI using multicomponent herbal preparation.
DOI:
https://doi.org/10.26641/2307-0404.2013.3.18997Ключові слова:
children, children's homes, local immunity, mucosal microflora of the nose and throat, seasonal prophylaxis of ARVIАнотація
A total of 116 children from children’s homes at the age from 3 to 17 years during clinical well-being were inspected. The question on possibility of immunological examination of organized groups of children and the need of seasonal prophylaxis of ARVI using multicomponent herbal preparation hase been submitted with the city department of health, city department of education, with heads of children's homes as official guardians of children, being in full compliance with the requirements of the biotic committee, considering ICH GCP guidelines and Helsinki Declaration on Bioethics, taking into account the rights of a child. The evaluation of the local immunity system in all children from orphanages during clinical well-being by non-invasive methods was done twice - before and after seasonal prophylaxis of ARVI. Standardized microbiological examination of nose and throat mucosa was used; the content of antimicrobial lactoferrin protein (test system Human Lactoferrin, Hycult ® biotech, NTV, "BioKhimMak»), α-defensins 1-3 (test system Human HNP 1-3, Hycult ® biotech, NTV, "BioKhimMak") with assessment of SIgA concentration (test system "Vector - BEST", Russia) in secretion of oropharyngeal cavity was determined. The presence of significant changes in the system of local immunity in the upper respiratory tract mucosa in children (101 humans) with frequent episodes of ARVI due to α-defensins 1-3 reduction and deficit of secretory immunoglobulin A concentrations in oropharyngeal secretions was shown. In 83.3% of cases this occurred in combination with dysbiosis of throat and nasal mucous membranes, the effect of dysbiosis on the local immunity state was confirmed by a correlation analysis. The efficacy of multicomponent herbal preparation in scheme of seasonal ARVI prevention in children was 88%, being proved by the formation of eubiosis of nose and throat mucous membranes in 78% of cases in combination with a significant increase of lactoferrin content and increase of S IgA concentration in the oropharyngeal secretions in these children.Посилання
Абатуров А.Е. Антимикробные энзимы сис¬те¬мы неспецифической защиты респираторного тракта / А.Е. Абатуров // Здоровье ребенка. – 2009 - №3(18) – С. 122 - 125.
Абатуров А.Е. Катионные антимикробные пе¬п¬тиды системы неспецифической защиты респи¬ра¬торного тракта: дефензины и кателицидины. Дефензины – молекулы переживающие ренессанс. Ч. 4 / А.Е. Аба¬туров // Здоровье ребенка. – 2012. – № 2. – С. 154-161.
Альбицкий В.Ю. Часто болеющие дети. Кли¬нико–социальные аспекты. Пути оздоровления / В.Ю. Альбицкий, А.А. Баранов. – Саратов: Изд-во Саратов. ун-та, 1986. – 184 с.
Аналіз та тенденції захворюваності дитячого населення України / Р.О. Моісеєнко, Я.І. Соколовська, Т.К. Кульчицька, Т.М. Бухановська // Соврем. педи¬а¬т¬рия – 2010 - №3(31) – С. 13-17.
Андрианова Е.Н. Дисбиоз верхнего отдела респираторного тракта и изменение функционального состояния органов дыхания у часто болеющих детей / Е.Н. Андрианова, Н.Ю. Снегирева, А.И.Рывкин // Пе¬диатрия. – 2009. – Т.87, №2 – С. 34 -39.
Герасимов А.Н. Медицинская статистика / А.Н. Герасимов. - М: Мед. информ. агентство, 2007. – 475 с.
Демографічна політика та соціальне сирітство: аналіз та прогноз сучасної ситуації / Т.А. Сіротченко, О.М. Гєтта, А.О. Бобришева, О.А. Топоркова // Здо¬ро¬вье ребенка. – 2011. - №3 (30) – С. 42- 46.
Извин А.И. Микробный пейзаж слизистой обо¬лочки верхних дыхательных путей в норме и патологи / А.И. Извин, Л.В. Катаева // Вестник отола¬рингологи. – 2009. – № 2. – С. 64-68.
Справочник «Компендиум 2012 — лекар¬ствен¬ные препараты» / под ред. В.Н. Коваленко - ISBN: 978-966-2066-46-3 [електронний ресурс http://compendium.com.ua]
Можливості корекції адаптивного та врод¬женого мукозального імунітету у дітей з повторними респіраторними захворюваннями / С.А. Якимович, Л.І. Чернишова, А.В. Чернишов [та ін.] // Соврем. пе¬ди¬а¬трия. – 2010. – № 4 (32). – С. 234.
Human defensins and LL-37 in mucosal immunity // M. Doss, M.R.White, T. Tecle, K.L. Hart¬shorn // J. Leukoc. Biol. – 2010. - Vol.87 – Р. 79 – 92.
Kelly D. Commensal gut bacteria: mechanisms of immune modulation / D. Kelly, S. Conway, R. Aminov // Trends. Immunol. – 2005. – Vol. 26, N 6. – Р. 326-333.
Abaturov AE. Antimikrobnye enzimy sistemy nespetsificheskoy zashchity respiratornogo trakta. Zdo¬rov'e rebenka. 2009;3(18):122-5.
Abaturov AE. Kationnye antimikrobnye peptidy sistemy nespetsificheskoy zashchity respiratornogo trakta: defenziny i katelitsidiny. Defenziny - molekuly perezhi¬vayushchie renessans (Ch. 4). Zdorov'e rebenka. 2012;2(37):154-61.
Al'bitskiy VYu, Baranov AA. Chasto boleyu¬shchie deti. Kliniko–sotsial'nye aspekty. Puti ozdorov¬leniya. Iz-vo Saratovskogo universiteta. 1986:184.
Moіseєnko RO, Sokolovs'ka YaІ, Kul'chits'ka TK, Bukhanovs'ka TM. Analіz ta tendentsії zakhvo¬ryuvanostі dityachogo naselennya Ukraїni. Sovremennaya pediatriya. 2010;3(31):13-7.
Andrianova EN, Snegireva NYu, Ryvkin AI. Dis¬bioz verkhnego otdela respiratornogo trakta i izmenenie funktsional'nogo sostoyaniya organov dykhaniya u chasto boleyushchikh detey. Pediatriya. 2009;87(2):34-9.
Gerasimov AN. Meditsinskaya statistika. M: Med. informatsionnoe agentstvo. 2007:475.
Sіrotchenko TA, Gєtta OM, Bobrisheva AO, To¬porkova OA. Demografіchna polіtika ta sotsіal'ne si¬rіtstvo: analіz ta prognoz suchasnoї situatsії. Zdorov'e rebenka. 2011;3(30):42-
Izvin AI, Kataeva LV. Mikrobnyy peyzazh sli¬zistoy obolochki verkhnikh dykhatel'nykh putey v norme i patologi.Vestnik otolaringologi. 2009;2:64-8.
Spravochnik «Kompendium 2012 — lekar¬stven¬nye preparaty» / Pod redaktsiey VN. Kovalenko - ISBN: 978-966-2066-46-3 [elektronniy resurs http://com¬pen¬dium.com.ua]
Yakimovich SA, Chernishova LІ, Cherni¬shov AV, Dons'koy BV, Galazyuk LV. Mozhlivostі ko¬rek¬tsії adaptivnogo ta vrodzhenogo mukozal'nogo іmunі¬tetu u dіtey z povtornimi respіratornimi zakhvoryuvan¬nyami. Sovremennaya pediatriya. 2010;4(32):234.
Doss M, White MR, Tecle T, Hartshorn KL. Hu¬man defensins and LL-37 in mucosal immunity. J. Leu¬koc. Biol. 2010;87:79-92.
Kelly D, Conway S, Aminov R. Commensal gut bacteria: mechanisms of immune modulation. Trends Im¬munol. 2005;26(6):326-33.
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