Features of biochemical indices and content of enzymes in the serum of syphilis patients with viral hepatites B and C in the course of treatment
DOI:
https://doi.org/10.26641/2307-0404.2021.3.241971Ключові слова:
functional state of the liver, results of treatment, syphilis, viral hepatitis B, viral hepatitis CАнотація
Objective – before and after the treatment to determine the functional state of the liver, serum levels of enzymes and biochemical indices in syphilis patients with viral hepatites B and C. The results of the study are based on the data from a comprehensive examination of 35 patients with syphilis alone and 127 patients with syphilis co-infected with viral hepatites B and C before and after treatment. Test methods: hepatology, rheogeopathography, enzyme content and biochemical parameters determined in the serum. According to the results of radionuclide hepatology it has been established that disorders of the functional capacity of the liver already occur in the early stages of the disease. The most significant disorders have been in the patients with the prescription of infection for more than 12 months and in the patients co-infected with viral hepatites B and C. A disorder of pigment metabolism and increased activity of transaminases have been revealed in early latent syphilis. In co-infection with viral hepatites B and C an increase in total bilirubin, Lactate dehydrogenase, Alanine transaminase, Aspartate aminotransferase and albumin has been revealed. Dysproteinemia has been revealed in patients with early latent syphilis co-infected with hepatitis C. Patients with early latent syphilis treated with immunomodulators tend to normalize these indices. In patients with syphilis a disorder of the functional state of the liver have been revealed already at an early stage of the disease. The most pronounced disorder of biochemical parameters and activity of liver enzymes are observed in syphilis patients with viral hepatites B and C, as well as in patients with early latent syphilis only with the prescription of the infection for more than 12 months; in such a case it is advisable to use drugs affecting the immune system.
Посилання
Antomonov MYu. [Mathematical processing and analysis of biomedical data]. 2nd ed. Kyiv; 2017. p. 578. Russian.
Zakharov SV, Zakharov VK. [Syphilis and the liver]. Dermatovenerologiya. Kosmetologiya. Seksopatologiya. 2015;1-2:81-85. Ukrainian.
Kamyshnikov VS. [Clinical laboratory diagnostics (methods and interpretation of laboratory studies)]. Мoskva: MEDpres-inform; 2015. p. 720. Russian.
Polukhina EV, Glazun LO. [Rheographic methods for studying the vascular system]. Tutorial. Khabarovsk: Institute for Advanced Training of Health Professionals; 2006. p. 98. Russian.
[On the approval of clinical protocols of granting medicare to the patients with the dermatological diseases. Order of the Ministry of Health of Ukraine dated 08.05.2009 No. 312]. Ukrainian. Available from: https://zakon.rada.gov.ua/rada/show/v0312282-09#Text
[On improvement of dermatological help to the population of Ukraine]. Order of the Ministry of Health of Ukraine dated 07.06.2004 No. 286]. Ukrainian. Available from: https://zakon.rada.gov.ua/rada/show/v0286282-04#Text
Radionov DV. [Seroresistance after treatment of syphilis and some reasons for its oc-currence]. Ukrainskyi zhurnal dermatolohii, venerolohii, kosmetolohii. 2014;1(52):7-13. Russian.
Rebrova OYu. [Statistical analysis of medical data. Application of Statistica applications]. Moskva: MediaSfera; 2018. p. 312. Russian.
[Modern approaches to laboratory diagnosis of syphilis. Guidelines. Order of the Ministry of Health of Ukraine dated 22.11.2013 No. 997]. Ukrainian. Available from: https://zakon.rada.gov.ua/rada/show/v0997282-13#n11
Seña AC, Zhang X-H, Li T, Zheng H-P, Yang B, Yang L-G, Salazar JC, Cohen MS, Moody MA, Radolf JD, Tucker JD. A systematic review of syphilis serological treatment outcomes in HIV-infected and HIV-uninfected persons: rethink-ing the significance of serological non-responsiveness and the serofast state after therapy. BMC Infect Dis. 2015;15:479. doi: https://doi.org/10.1186/s12879-015-1209-0
Russell NK, Nazar K, Pino S del, Gonzalez MA, Bermúdez XPD, Ravasi G. HIV, syphilis, and viral hepatitis among Latin American indigenous peoples and Afro-descendants: a systematic review. Rev Panam Salud Publica. 2019;43:e17. doi: https://doi.org/10.26633/RPSP.2019.17
Pizzarossa AC, Rebella M. Hepatitis in patients with syphilis: an overlooked asso-ciation. BMJ Case Rep. 2019;12(1):bcr-2018-226918. doi: https://doi.org/10.1136/bcr-2018-226918
Mutagoma M, Nyirazinyoye L, Sebuhoro D, Riedel DJ, Ntaganira J. Syphilis and HIV prevalence and associated factors to their co-infection, hepatitis B and hepatitis C viruses prevalence among female sex workers in Rwanda. BMC Infect Dis. 2017;17:525. doi: https://doi.org/10.1186/s12879-017-2625-0
Zakharov SV, Zakharov VK, Gorbuntsov VV. The content of cytokines in the blood serum of patients with early latent syphilis in process of treatment. Medicni perspektivi. 2019;24(3):96-101. doi: https://doi.org/10.26641/2307-0404.2019.3.181889
Zhang C, Ren Q, Chang W. Epidemiological Features and Risk Factors for Acquiring Hepatitis B, Hepatitis C and Syphilis in HIV-Infected Patients in Shaanxi Province, Northwest China. Int J Environ Res Public Health. 2020 Mar;17(6):1990. doi: https://doi.org/10.3390/ijerph17061990
Angeleri P, Levite V, Vidiella G, Solari J, Coronel E, Adaszko D, Adaszko A, Moyano C, Bouchet D, Cuello H, Molfese V, Skarzauskas R, Vila M, Falistoc¬co C, Pando MA. Viral hepatitis and Treponema pallidum prevalence in persons who underwent premarital blood tests in Argentina. Sci Rep. 2019;9:9611. doi: https://doi.org/10.1038/s41598-019-45891-9
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