Modern aspects of surgical treatment of patients with endometrial cancer (own experience)
DOI:
https://doi.org/10.26641/2307-0404.2022.1.254370Ключові слова:
endometrial cancer, laparotomy, laparoscopy, surgery, lymph dissection, pelvic, paraaortic, complicationsАнотація
In recent years, endometrial cancer has taken the lead among oncological processes of the female reproductive system. The high prevalence of this disease leads to disability of the working-age population, large socio-economic losses, which determines the relevance of this problem and the search for new methods of screening, diagnostics, optimal selection of treatment, thereby affecting the quality of future life. The choice of the method of treatment of patients depends on the following main factors: age, general condition, reproductive plans of the patient, histological type of tumor, degree of its differentiation, size, localization in the uterine cavity, prevalence of the tumor process. The main treatment for endometrial cancer is surgical treatment. The principles of surgical treatment consist in the individual selection of the volume of surgical intervention, adequate lymphadenectomy, prevention of recurrence and metastases. Lymph node dissection for cancer of the uterine body has always been a controversial issue. Lymphadenectomy is necessary to accurately establish the stage of endometrial cancer. In recent years, the discussion about laparoscopic lymph node dissection in comparison with open access, to what level lymphadenectomy should be performed, how many lymph nodes, frequency of complications, prognosis of patient survival, frequency of relapses has been developing. The article highlights own vision of the role of lymphadenectomy both in laparotomy and in laparoscopy, the importance of the volume of surgical intervention and complications for each type of treatment.
Посилання
Antomonov MYu. [Mathematical processing and analysis of medical and biological data]. Kyiv: MYTs «Medynform»; 2018. p. 579. ISBN 978-966-409-202-6. Russian.
Fedorenko Z, Goulak L, Gorokh Ye, Ryzhov A, Soumkina O, Koutsenko L. [Cancer in Ukraine: incidence, mortality, activities of the oncological service]. [Internet]. 2020. Available from: www.ncru.inf.ua/publications/
ACOG practice bulletin, clinical management guidelines for obstetrician-gynecologists, number 65, August 2018: management of endometrial cancer. Obstet Gynecol. 2018 Aug;106(2):413-25.
Amanta F, Mirzab M, Creutzbergc C. FIGO cancer report 2015. Cancer of the corpus uteri. Int J Gynaecol Obstet. 2018 Oct;143 Suppl 2:37-50. doi: https://doi.org/10.1002/ijgo.12612
American Joint Committee on Cancer. Corpus Uteri-Carcinoma and Carcinosarcoma. In: AJCC Cancer Staging Manual. 8th ed. New York, NY: Springer; 2017:661-669. doi: https://doi.org/10.1007/978-3-319-40618-3_53
Bell JG, Patterson DM, Klima J, Harvison M, Rath K, Reid G. Outcomes of patients with low-risk endo¬metrial cancer surgically staged without lymphadenec¬tomy based on intra-operative evaluation. Gynecol Oncol. 2014;134 doi: https://doi.org/10.1016/j.ygyno.2014.06.028
Paño B, Sebastià C, Ripoll E, Paredes P, Salvador R, Buñesch L, et al. Pathways of Lymphatic Spread in Gynecologic Malignancies RadioGraphics. 2015 May-Jun;35:916-45. doi: https://doi.org/10.1148/rg.2015140086
Bolliger M, Kroehnert AJ, Molineus F, Kandioler D, Schindl M, Riss P. Experiences with the standardized classification of surgical complications (Clavien-Dindo) in general surgery patients. Eur Surg. 2018;50:256-61. doi: https://doi.org/10.1007/s10353-018-0551-z
Colombo N, Creutzberg C, Amant F, et al. ESMO-ESGO-ESTRO Consensus conference on endometrial cancer. Diagnosis, treatment and follow-up. Int J Gynecol Cancer. 2016;26(1):2-30. doi: https://doi.org/10.1097/IGC.0000000000000609
Egemann H, Ignatov T, Kaiser K, et al. Survival of lymphadenectomy in endometrial cancer. J Cancer Res Clin Oncol. 2016;142:1051-60. doi: https://doi.org/10.1007/s00432-015-2109-9
Bray F, Ferlay J, Soerjomataram I, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. Cancer J Clin. 2018;68(6):394-424. doi: https://doi.org/10.3322/caac.21492
Kim M, Choi C, Kim K, Lim MC, Park JY, Hong JH, et al. Three-year recurrence-free survival in patients with a very low risk of endometrial cancer who did not undergo lymph node dissection (tree retro): a Korean Multicenter Study. Int J Gynecol Cancer. 2018 Jul;28(6):1123-9. doi: https://doi.org/10.1097/IGC.0000000000001270
Lin Li, Mingming Tang, Dan Nie, Jinhai Gou, Zhengyu L. Para‐aortic lymphadenectomy did not im¬prove overall survival among women with type I endometrial cancer. Int J Gynaecol Obstet. 2020 Aug;150(2):163-8. Epub 2020 Jun 17. doi: https://doi.org/10.1002/ijgo.13228
Toptas T, Simsek T. Survival analysis only after pelvic lymphadenectomy compared with combined pelvic and para-aortic lymphadenectomy in patients with endo¬metrial endometrial cancer. Oncol Lett. 2015 Jan;9(1):355-64. doi: https://doi.org/10.3892/ol.2014.2653
Turkler C, Kulhan M, Kulhan N, Ata N, Sanci M, Ozeren M. Role of lymphadenectomy in disease-free and overall survival on low risk endometrium cancer patients-Ginekol Pol. 2018;89(6):311-5. doi: https://doi.org/10.5603/GP.a2018.0053
##submission.downloads##
Опубліковано
Як цитувати
Номер
Розділ
Ліцензія
Авторське право (c) 2022 Медичні перспективи
Ця робота ліцензується відповідно до Creative Commons Attribution 4.0 International License.
Submitting manuscript to the journal "Medicni perspektivi" the author(s) agree with transferring copyright from the author(s) to publisher (including photos, figures, tables, etc.) editor, reproducing materials of the manuscript in the journal, Internet, translation into other languages, export and import of the issue with the author’s article, spreading without limitation of their period of validity both on the territory of Ukraine and other countries. This and other mutual duties of the author and all co-authors separately and editorial board are secured by written agreement by special form to use the article, the sample of which is presented on the site.
Author signs a written agreement and sends it to Editorial Board simultaneously with submission of the manuscript.