Role of adjuvant therapy in the treatment of helicobacter pylori infection in children.

O. N. Gerasymenko

doi:10.26641/2307-0404.2014.2.28340

Автор(и)

O. N. Gerasymenko

DOI:

https://doi.org/10.26641/2307-0404.2014.2.28340

Ключові слова:

children, chronic gastroduodenitis, Helicobacter pylori, eradication, probiotic, sCD14

Анотація

The aim was to study the effect of combined probiotic containing Lactobacillus acidophilus, Bifidobacterium infantis, Enterococcus faecium, on H.pylori eradication efficacy in the treatment of children with chronic H.pylori- associated gastroduodenitis in the scheme of "triple" therapy of H.pylori eradication. Determination of total serum Ig M , A, G protein to Ag SagA H. pylori, breathing "Helik" test, rapid urease "Helpil" test ; that of concentration of serum sCD14 was conducted. The study group included 20 children who received standard "triple" eradication therapy for 7 days and 1 caps. of probiotic 3 times a day for 4 weeks, control group (20 children) – who received only standard eradication therapy. It is shown that combined use of probiotics in the treatment of Helicobacter pylori infection enhances effectiveness of eradication of H.pylori. In the basis of action of probiotic strains of the drug is an anti-inflammatory effect mediated by the impact on non-specific mechanisms of innate immunity, provided by molecular mechanism responsible for induction of sCD14 synthesis.

Біографія автора

O. N. Gerasymenko

SE "Dnipropetrovsk medical academy of Health Ministry of Ukraine"
Department of Faculty of Pediatrics and Medical Genetics
Dzerzhinsky st., 9, Dnipropetrovsk, 49044, Ukraine

Посилання

Абатуров О.Є.Модуляція активності TLR4 епітеліоцитів слизової оболонки шлунка при хелікобактерній інфекції / О.Є. Абатуров, О.М. Герасименко // Соврем. педиатрия. – 2009. - №6(28). – С. 141-146.

Антомонов М.Ю. Математическая обработка и анализ медико-биологических данных / М.Ю. Антомонов– К.: Фірма малого друку, 2006. – 558 с.

Дефензины и дефензин-зависимые заболевания /А.Е. Абатуров, О.Н. Герасименко, И.Л. Высочина, Н.Ю.Завгородняя.- Одесса: «Изд-во ВМВ», 2011.– 265 с.

Микробиологическая диагностика дисбактериозов: метод. рекомендации. - К., 1998. - 14 с.

Adjuvant probiotics improve the eradication effect of triple therapy for Helicobacter pylori infection / Y.Q. Du, T. Su, J.G. Fan [et al] // World J. Gastroenterol. – 2012. – Vol. 18, N 43. – P. 6302-6307.

Eradication of Helicobacter pylori infection by the probiotic strains Lactobacillus johnsonii MH-68 and L. salivarius ssp. salicinius AP-32 / P.S. Hsieh, Y.C. Tsai, Y.C. Chen [et al.] // Helicobacter. – 2012. – Vol. 17, N 6. – P. 466-77.

Gotteland M. Modulation of Helicobacter pylori colonization with cranberryjuice and Lactobacillus johnsonii La1 in children / M. Gotteland, M. Andrews, M. Toledo // Nutrition. – 2008. – Vol. 24, N 5. – P.421-426.

Helicobacter pylori eradication: sequential therapy and Lactobacillus reuteri supplementation / C. Efrati, G. Nicolini, C. Cannaviello [et al.] // World J. Gastro¬enterol. – 2012. – Vol. 18, N 43. – P. 6250-6254.

Meta-analysis of randomized controlled trials on the efficacy of probiotics in Helicobacter pylori eradication therapy in children / S. Li, X.L. Huang, J.Z. Sui, [et al.] // Eur. J. Pediatr. – 2013. – N 10.

Vidal K. Lipoteichoic Acids from Lactobacillus johnsonii Strain La1 and Lactobacillus acidophilus Strain La10 Antagonize the Responsiveness of Human Intestinal Epithelial HT29 Cells to Lipopolysaccharide and Gram-Negative Bacteria / K. Vidal, A. Donnet-Hughes, D. Granato // Infect Immun. – 2002. – Vol. 70, N 4. – P. 2057-2064.

Zheng X. Lactobacillus-containing probiotic sup¬plementation increases Helicobacter pylori eradication rate: Evidence from a meta-analysis / X. Zheng, L.Lyu, Z.Mei // Rev. Esp. Enferm Dig. – 2013. –Vol. 105, N 8. – P. 445-453.

Abaturov AE, Gerasymenko ON, Vysochyna IL, Zavhorodnyaya NYu. [Defensins and defensin-dependent diseases]. Odessa. 2011;265. Russian.

Antomonov MJu. [Mathematical processing and analysis of biomedical data]. K.: Fіrma malogo druku. 2006;558. Russian.

Abaturov OYe, Gerasymenko OM. [Modulation of TLR4 epithelial cells of the gastric mucosa by H. pylori infection]. Modern Pediatrics. 2009;6(28):141-6. Ukrainian.

[Microbiological diagnosis dysbiosis: Guidelines]. Kiev. 1998;14. Russian.

Du YQ, Su T, Fan JG, Lu YX, Zheng P, Li XH, Guo CY, Xu P, Gong YF, Li ZS. Adjuvant probiotics improve the eradication effect of triple therapy for Helicobacter pylori infection. World J Gastroenterol. 2012;18(43):6302-07. doi:10.3748/wjg.v18.i43.6302.

Hsieh PS, Tsai YC, Chen YC, Teh SF, Ou CM, King VA. Eradication of Helicobacter pylori infection by the probiotic strains Lactobacillus johnsonii MH-68 and L. salivarius ssp. salicinius AP-32. Helicobacter. 2012;17(6):466-77. doi: 10.1111/j.1523-5378.2012.00992.x.

Gotteland M, Andrews M, Toledo M, Munoz L, Caceres P, Anziani A, Wittig E, Speisky H, Salazar G. Modulation of Helicobacter pylori colonization with cranberryjuice and Lactobacillus johnsonii La1 in children. Nutrition. 2008;24(5):421-6. doi: 10.1016/j.nut.2008.01.007.

Efrati C, Nicolini G, Cannaviello C, O'Sed NP, Valabrega S. Helicobacter pylori eradication: sequential the¬rapy and Lactobacillus reuteri supplementation. World J Gastroenterol. 2012;18(43):6250-4. doi: 10.3748/ wjg.v18.i43.6250.341.

Li S, Huang XL, Sui JZ, Chen SY, Xie YT, Deng Y, Wang J, Xie L, Li TJ, He Y, Peng Q.L., Qin X., Zeng Z.Y. Meta-analysis of randomized controlled trials on the efficacy of probiotics in Helicobacter pylori eradication therapy in children. Eur J Pediatr; 2013.

Vidal K, Donnet-Hughes A, Granato D. Lipoteichoic Acids from Lactobacillus johnsonii Strain La1 and Lactobacillus acidophilus Strain La10 Antagonize the Responsiveness of Human Intestinal Epithelial HT29 Cells to Lipopolysaccharide and Gram-Negative Bacteria. In¬fect Immun. 2002;70(4):2057-64. doi: 10.1128/ IAI.70.4.2057 -2064.2002.

Zheng X, Lyu L, Mei Z. Lactobacillus-containing probiotic supplementation increases Helicobacter pylori eradication rate: Evidence from a meta-analysis. Rev Esp Enferm Dig. 2013;105(8):445-53.