Behavioral disorders in rats with chronic myocardial dysfunction.

A. G. Rodinskiy; Yu. V. Kozlova

doi:10.26641/2307-0404.2014.3.28506

Автор(и)

A. G. Rodinskiy
Yu. V. Kozlova

DOI:

https://doi.org/10.26641/2307-0404.2014.3.28506

Ключові слова:

behavioral disorders, myocardial dysfunction, doxorubicin, emotion, anxiety

Анотація

Observation of cardiologists and psychiatrists suggest that cardiovascular diseases and depression are the most common and frequent comorbid conditions. Therefore the aim of the study was to identify behavioral disorders in rats on the background of myocardial dysfunction in the experiment. Material of the research: 60 adult male rats of Wistar line, weighing 200-220 g, divided into 2 groups - control and experimental. Myocardial dysfunction was modeled by intraperitoneal injection of doxorubicin by 5 mg/kg of animal weight. To verify the model of myocardial dysfunction ECG and histological examination of the myocardium were performed. Evaluation of higher divisions of the CNS reactions was performed using the "open field" method by such indicators: vertical and horizontal motor activity (decreased by 71,4%), acts and defecation boluses (down by 85-88%), the number of burrows (decreased by 57-90%), grooming (decreased by 23%), all parameters were reliable (in p<0,05). There was a gradual decline of rats’ emotionality, CNS depression and increased anxiety. It was found that behavioral disorders in the experiment were typical for anxiety and depression states.

Біографії авторів

A. G. Rodinskiy

SE "Dnipropetrovsk medical academy of Health Ministry of Ukraine"
Department of physiology
Dzerzhins'kogo str., 9, Dnipropetrovsk, 49044, Ukraine

Yu. V. Kozlova

SE "Dnipropetrovsk medical academy of Health Ministry of Ukraine"
Department of physiology
Dzerzhins'kogo str., 9, Dnipropetrovsk, 49044, Ukraine

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