Experimental study of effectiveness of local application of electroneurostimulation, cortexin and methylprednisolone in acute spinal cord injury.
DOI:
https://doi.org/10.26641/2307-0404.2014.3.30345Ключові слова:
electroneurostimulation, cortexin, spinal injuryАнотація
The tasks were to investigate the effect of topical electroneurostimulation, cortexin and methylprednisolone in acute spinal cord injury in electrophysiological experiments on laboratory rats. The animals underwent half transection of the spinal cord in the lower-thoracic area to simulate Brown-Sequard’s syndrome. Drugs were administered subdurally once daily in the dose of 0.03 mg for cortexin and 0.7 mg for methylprednisolone during 72 hours. Electrophysiological studies were carried out using standard electrophysiological apparatus. Reliable changes of bioelectric indicators in neuromuscular complex during topical application of electrical stimulation, as well as in administered methylprednisolone, failed to be found. However, local application of cortexin in terms of traumatic spinal cord injury due the antioxidant and neurotrophic effect results in improvement of bioelectrical indicators; this is manifested in reliable (p<0.05) increase of amplitude of the background electromyogram impulses at rest by 33% and increase of spontaneous oscillations frequency by 29.82%.Посилання
Акрас А. Церебролизин: общие сведения / А. Акрас // 3–й междунар. симпозиум по церебролизину. – М., 1991. – C. 5.
Виндиш М. Церебролизин – последние резуль¬таты в оценке мультимодального действия препарата / М. Виндиш // 3–й междунар. симпозиум по церебро¬ли¬зину. – М., 1991. – С. 81–86.
Гейли P.JI. Неотложная ортопедия. Позвоноч¬ник / P.JI. Гейли, Д.У. Спайт, P.P. Симон [пер. с англ.]. – М.: Медицина, 1995.– 432 с.
Громова О.А. Церебролизин: новые грани воз¬действия / О.А. Громова, Т.В. Авдеенко, Е.М. Бурцев // Журнал неврологии и психиатрии им. С.С. Корса¬ковка. – 1998. – № 1. – С. 36–37.
Кластогенные, анеугенные, прооксидантные и антиоксидантные свойства некоторых нейротропных препаратов / Д.Д. Гайнетдинова, В.В. Семенов, М.Ф. Ис¬маги¬лов, B.C. Харитонов // Эксперим. и кли¬нич. фар¬ма¬кология. – 2006. – Т. 69, № 3. – С. 58-62.
Нейротрофические факторы мозга. Спра¬воч¬но–информационное издание / под ред. О.А. Го¬маз¬гова. – М., 2004. – С. 299.
Ромоданов А.П. Некоторые проблемы травмы поз¬воночника и спинного мозга по данным зару¬бежной литературы текст. / А.П. Ромоданов, К.Э. Ру¬дяк // Вопросы нейрохирургии. – 1980. – № 1. – С. 56–61.
Стихина Н.Г. Екатеринбург Клинико–нейро¬фи¬зиологические аспекты последствий тяжелой по¬зво¬ночно–спинномозговой травмы при разных уров¬нях повреждения спинного мозга и возможности вос¬становительного лечения: автореф. дис. на соискание учен. степени канд. мед. наук / Н.Г. Стихина. – Екате¬ринбург, 2006. – 21 с.
Цимбалюк В.І. Реконструктивно–відновна хі¬рур¬гія спинного мозку / В.І. Цимбалюк, Ю.Я. Ямінсь¬кий. – К.: Авіцена, 2009. – 248с.
An imposed oscillating electrical field improves the recovery of function in neurologically complete pa¬raplegic dogs / R.B. Borgens, J.P. Toombs, G. Breur [et al.] // J. Neurotrauma. – 1999.–Vol. 16, N 7. – P. 639–657.
Antiapoptotic effects of the peptidergic drug cerebrolysin on primary cultures of embryonic chick cor¬tical neurons / M. Hartbauer, B. Hutter–Paier, G. Sko¬fitsch [et al.] // J. Neural. Transm. – 2001. – Vol. 108, N 4. – P. 459–473.
Bowes M.P. Monoclonal antibody to the ICAM–1 adhesion site reduces neurological damage in a rabbit cerebral embolism stroke model / M.P. Bowes, J.A. Zivin, R. Rothlein // Exp. Neurol. – 1993. – Vol. 119. – P. 215–219.
Bracken M.B. Steroids for Acute Spinal Cord Injury (Review) / M.B. Bracken // Cochrane Library. – 2012. – Issue 10. – P. 1–51.
Cerebrovascular Disease / E.I. Gusev, V.I. Skvort¬sova, N.F. Myasoedov [et al.]. – 1999. – Vol. 9. – Р. 126.
Functional electrical stimulation helps replenish progenitor cells in the injured spinal cord of adult rats / D. Becker, D.S. Gary, E.G. Rosenzweig [et al.] // Exp. Neurol. – 2010. – Vol. 222, N 2. – P. 211–218.
Holtz A. Spinal Cord Injury / A. Holtz, R. Levi // Oxford university press, 2010. — Р. 9–162, 175–186, 253–302.
Windisch M. Neuropsychiatry / M. Windisch, A. Piswanger – 1987. – Vol. 1, N 2. – P. 83–88.
Akras A. [Cerebrolysin: general information]. 3–y mezhdunarodnyy simpozium po tserebrolizinu. Moscow. 1991;5. Russian.
Vindish M. [Cerebrolysin – latest results in the evaluation of multimodal drug action]. 3–y mezhdu¬narod¬nyy simpozium po tserebrolizinu. Moscow. 1991;81–86. Russian.
Geyli RL, Spayt DU, Simon PP. [Emergency orthopedics. spine text]. Moscow. Meditsina. 1995;432. Russian.
Gromova OA, Avdeenko TV, Burtsev EM. [Ce¬rebro¬lysin new faces exposure] Zhurn. nevrol. i psikhiatr. 1998;1:36–37. Russian.
Gaynetdinova DD, Semenov VV, Ismagilov MF, Kharitonov BC [Clastogenic, aneugenic, prooxidant and antioxidant properties of some neurotropic drugs]. Eks¬pe¬ri¬men¬tal'naya i klinicheskaya farmakologiya. 2006;3(69):58–62. Russian.
[Neurotrophic factors brain. Reference edition]. Gomazgov OA, editor. Мoscow. 2004;12–61, 258–99. Rus¬sian.
Romodanov AP, Rudyak KE. [Some injury prob¬lems of the spine and spinal cord according to foreign lite¬rature]. Voprosy neyrokhirurgii. 1980;1:56–61. Russian.
Stikhina NG. [Clinical and neurophysiological aspects of the consequences of a severe spinal cord injury at different levels of spinal cord injury and the possibility of rehabilitation treatment (dissertation)]. Ekaterinburg; 2006. Russian.
Tsimbalyuk VI, Yamіns'kiy YY. [Reconstructive surgery of the spinal cord]. Кiiv. Аvicena. 2009;248. Russian.
Borgens RB, Toombs JP, Breur G, Widmer WR, Waters D, Harbath AM, March P, Adams LG. An im¬posed oscillating electrical field improves the recovery of function in neurologically complete paraplegic dogs. J Neurotrauma. 1999;16(7):639–57.
Hartbauer M, Hutter–Paier B, Skofitsch G et al. Antiapoptotic effects of the peptidergic drug cerebrolysin on primary cultures of embryonic chick cortical neurons J. Neural. Transm. 2001;108(4):459–73.
Bowes MP, Zivin JA, Rothlein R. Monoclonal antibody to the ICAM–1 adhesion site reduces neuro¬logical damage in a rabbit cerebral embolism stroke mo¬del. Exp Neurol. 1993;119:215–9.
Bracken M.B. Steroids for Acute Spinal Cord Injury (Review). The Cochrane Library. 2012;10:1–51.
Gusev EI, Skvortsova VI, Myasoedov NF et al. Cerebrovascular Disease 1999;9:126.
Becker D, Gary DS, Rosenzweig EG, Grill WM, McDonald JW. Functional electrical stimulation helps rep¬lenish progenitor cells in the injured spinal cord of adult rats. Exp. Neurol. 2010;222(2):211–8.
Holtz A, Levi R. Spinal Cord Injury. Oxford uni¬versity press. 2010. 9–162, 175–86, 253–302.
Windisch M, Piswanger A. Neuropsychiatry. 1987;1(2):83–88.
##submission.downloads##
Опубліковано
Як цитувати
Номер
Розділ
Ліцензія
Авторське право (c) 2017 Медичні перспективи
Ця робота ліцензується відповідно до Creative Commons Attribution-NonCommercial 4.0 International License.
Submitting manuscript to the journal "Medicni perspektivi" the author(s) agree with transferring copyright from the author(s) to publisher (including photos, figures, tables, etc.) editor, reproducing materials of the manuscript in the journal, Internet, translation into other languages, export and import of the issue with the author’s article, spreading without limitation of their period of validity both on the territory of Ukraine and other countries. This and other mutual duties of the author and all co-authors separately and editorial board are secured by written agreement by special form to use the article, the sample of which is presented on the site.
Author signs a written agreement and sends it to Editorial Board simultaneously with submission of the manuscript.
