Morphologic and immune-histochemic peculiarities of placenta in its dysfunction in anemia of pregnancy.

I. A. Ancheva

doi:10.26641/2307-0404.2014.4.35595

Автор(и)

I. A. Ancheva

DOI:

https://doi.org/10.26641/2307-0404.2014.4.35595

Ключові слова:

pregnancy, placenta dysfunction, iron deficiency anemia, macroscopy of placenta

Анотація

Placental dysfunction occurs in 17-35% of pregnant women. Iron deficiency anemia complicating pregnancy and childbirth affects fetal development. In its turn, pregnancy contributes to the rapid progress of iron deficiency anemia. The aim of the study was to evaluate the morphological and immunohistochemical features of the placenta in its dysfunction in women with anemia during pregnancy. The study was performed on clinical bases of the Department of Obstetrics and Gynecology №1 of ONMedU (Odessa) and pathologic department of SI " IPOG NAMSU" (Kiev). The complex dynamic examination of pregnant women with subsequent examination of the placenta was performed. Patients were divided into 3 groups. 1^stgroup consisted of pregnant women with physiological pregnancy and childbirth (n=10), 2^nd group included women suffering from anemia during pregnancy (n=10); 3^rd group consisted of women with pregnancy accompanied with placental dysfunction and anemia (n=10). Organometric, macroscopic, general histological, micrometer, histochemical and immunohistochemical methods were used. It is shown that reduction of incidence of regeneration - proliferative marker Ki -67 in the nuclei of villous syncytial structure is more pronounced in the development of placental dysfunction against a background of anemia during pregnancy.

Біографія автора

I. A. Ancheva

Odessa National Medical University
Valihovs'ky bystr., 2, Odessa, 65000, Ukraine

Посилання

Айламазян, Э.К. Молекулярные маркеры ста¬ре¬ния и зрелости плаценты / Э.К. Айламазян, И.М. Кри¬ветной // Мать и дитя: материалы VII Рос. форума. – М., 2005. – С. 12-13.

Давиденко І.С. Гістоморфологія порушень до¬зрі¬ван¬ня плаценти при залізодефіцитній анемії вагіт¬них / І. С. Давиденко // Вісник наукових досліджень. – 2002. – № 2, додаток. – С. 33-35.

Коноводова Е.Н. Профилактика и лечение же¬лезо¬дефицитных состояний у беременных и родиль¬ниц / Е.Н. Коноводова, В.А. Бурлев, Р.Г. Шмоков // Ле¬ча¬щий врач – 2010. - № 3 - С. 33-36.

Радзинский В.Е. Акушерская агрессия / В.Е. Рад¬зинский. – М.: Изд-во журнала StatusPraesens, 2011. – 688 с.

Фетоплацентарная недостаточность и пери¬на¬тальные осложнения у беременных с железоде¬фи¬цит¬ной анемией / Л.С. Логутова, К.Н. Ахвледиани, В.А. Пет¬рухин [и др.] // Рус. мед. журнал. – 2010. – Т. 18, № 19. – С. 1215-1219.

A quantitative analysis of transcriptionally active syncytiotrophoblast nuclei across human gestation. / N.M Fo¬garty, T.M. Mayhew, A.C. Ferguson-Smith, G.J. Burton // J. Anat – 2011 – Vol. 219, N 5. – P. 601-610.

Burton G.J. Oxygen, the Janus gas; its effects on human placental development and function / G.J. Burton // J. Anat. – 2009 – Vol. 215, N 1. – P. 27-35.

Burton G.J. The influence of the intrauterine en¬vironment on human placental development / G.J. Burton, E. Jauniaux, D.S. Charnock-Jones // Int. J. Dev. Biol. – 2010 – Vol. 54, N 2–3. – P. 303-312.

Hargitai B. Examination of the human placenta / B. Hargitai, T. Marton, B. Cox // J. Clin. Pathol. – 2004 – Vol. 57. – P. 785-792.

Induction versus expectant monitoring for in¬trauterine growth restriction at term: randomised equiva¬lence trial (DIGITAT) / K.E. Boers, S.M. Vijgen, D. Bijlenga [et al.] // BMJ. – 2010 – Vol. 341. – P. 7087.

Mayhew T.M. Turnover of human villous tropho¬blast in normal pregnancy: what do we know and what do we need to know? / T.M. Mayhew // Placenta. - 2014 – Vol. 35, N 4. – P. 229-240.

Promotion of angiogenesis by human endometrial lymphocytes / C. Dunk, S. Smith, A. Hazan [et al.] // Im¬munol Invest. – 2008 – Vol. 37, N 5. – P. 583-610.

Rheological and physiological consequences of conversion of the maternal spiral arteries for utero¬pla¬cental blood flow during human pregnancy / G.J. Burton, A.W. Woods, E. Jauniaux, J.C. Kingdom // Placenta. – 2009. – Vol. 30, N 6. – P. 473–482.

Rounded intraplacental haematomas due to de¬cidual vasculopathy have a distinctive morphology / B. Fitzgerald, P. Shannon, J. Kingdom, S..Keating // J. Clin. Pathol. – 2011. – Vol. 64, N 8. – P. 729-732.

The impact of ultrasonographic placental archi¬tecture on antenatal course, labor and delivery in a low-risk primigravida population / S.M. Cooley, J.C. Don¬nel¬ly, T. Walsh [et al.] // J. Matern. Fetal Neonatal Med. – 2011. – Vol. 24, N 3. – P. 493-497.

REFERENCES

Ailamazyan EK. [Molecular markers of aging and maturity of the placenta Mother and Child: Materials VII Ros. offline]. Moscow, 2005;12-13. Russian.

Davydenko ІS. [Histomorphology of disorder of placenta maturation in iron deficiency anemіa of pre¬g¬nants News of scientific researches]. 2002;2:33-35. Ukrainian.

Konovodova EN, BurleVA, Shmokov RG. [Pre¬vention and treatment of iron deficiency in pregnant and postpartum women]. EN Physician. 2010;3:33-36. Russian.

Radzinsky VE [Obstetric aggression]. Moscow: Publishing House of Journal StatusPraesens, 2011;688. Russian.

Logutova LS, KN Akhvlediani, Petruhin VA, Pavlova TV, Melnikov AP, Bashakin NF, Zhilyaeva OD, Kovalenko TS, Magilevskaya EV. [Placental insuf¬ficien¬cy and perinatal complications in pregnant women with iron deficiency anemia]. Russian Medical Journal. 2010;18(19):1215-19. Russian.

Fogarty NM, Mayhew TM, Ferguson-Smith AC, Burton GJ. A quantitative analysis of transcriptionally ac¬tive syncytiotrophoblast nuclei across human gestation. J Anat. 2011;219(5):601–10.

Burton GJ. Oxygen, the Janus gas; its effects on human placental development and function. J Anat. 2009;215(1):27–35.

Burton GJ, Jauniaux E, Charnock-Jones DS. The in¬fluence of the intrauterine environment on human pla¬cen¬tal development. Int J Dev Biol. 2010;54(2–3):303–12.

Hargitai B, Marton T, Cox BM. Examination of the human placenta. Journal of Clinical Pathology. 2004;57:785-92.

Boers KE, Vijgen SM, Bijlenga D, van der Post JA, Bekedam DJ, Kwee A, van der Salm PC, van Pampus MG, Spaanderman ME, de Boer K, Duvekot JJ, Bremer HA, Ha¬saart TH, Delemarre FM, Bloemenkamp KW, van Meir CA, Willekes C, Wijnen EJ, Rijken M, le Cessie S, Roumen FJ, Thornton JG, van Lith JM, Mol BW, Scherjon SA; DIGITAT study group. Induction versus expectant monitoring for intrauterine growth restriction at term: randomised equivalence trial (DIGITAT). BMJ. 2010;21:341:c7087.

Mayhew TM. Turnover of human villous trophoblast in normal pregnancy: what do we know and what do we need to know? Placenta. 2014;35(4):229-40.

Dunk C, Smith S, Hazan A, Whittle W, Jones RL. Promotion of angiogenesis by human endometrial lymphocytes. Immunol Invest. 2008;7(5);583–610.

Burton GJ, Woods AW, Jauniaux E, Kingdom JC. Rheological and physiological consequences of conversion of the maternal spiral arteries for uteroplacental blood flow during human pregnancy. Placenta. 2009;30(6):473–82.

Fitzgerald B, Shannon P, Kingdom J, Keating S. Rounded intraplacental haematomas due to decidual vasculopathy have a distinctive morphology. J Clin Pathol. 2011;64(8):729–32.

Cooley SM, Donnelly JC, Walsh T, McMahon C, Gillan J, Geary MP. The impact of ultrasonographic placental architecture on antenatal course, labor and delivery in a low-risk primigravid population. J Matern Fetal Neonatal Med. 2011;24(3):493-7.