The role of thyroid hormones in regulating of fatty acid spectrum of brain lipids: ontogenetic aspect.
DOI:
https://doi.org/10.26641/2307-0404.2016.2.71747Ключові слова:
hypothyroidism, neocortex, hipokam, polyunsaturated fatty acids, ontogenesisАнотація
In experiments on rats of three age groups the role of thyroid hormones in the regulation of fatty acid spectrum of cortical and hippocampus lipids was studied. It was found that on the background of decreased thyroid status content of polyunsaturated fractions of free fatty acids, significantly changed depending on the age of the animals. In particular, in juvenile rats hypothyroidism was accompanied by a decrease almost twice the number of pentacodan acid decreased lipids viscosity in neurocortex. In old rats reduce of pentacodan acid in the cortex (38%) was supplemented by significant (77%) decrease in linoleic and linolenic acids. Unlike the two age groups deficiency of thyroid hormones in young animals caused accumulation of free polyunsatarated fatty acids (C18: 2.3) in the cerebral cortex by 74%, which may be associated with a decrease of this fraction in fatty acid spectrum of lipids and increase of viscosity properties of the membranes. These restructuring may be associated with modulation of synaptic transmission of specific neurotransmitter systems in the brain.Посилання
Demchenko OM. [Cognitive activity of rats under thyroid dysfunction]. Visnyk problem biologii' i me-dycyny. 2014;2(109):127-32. Ukrainian.
Zolotuhyn SE, Mahneva AV Shpachenko NN, et al. [Changing activity of oxidant-antioxidant systems in hypothyroidism]. Ukraїns'kiy morfologіchniy al'manakh. 2011;9(3):114-6. Russian.
Kokunyn VA. [Statistical data processing with a small number of trials] Ukrai'ns'kyj biohimichnyj zhurnal. 1975;47(6):776-91. Russian.
Prokhorova MI. [Methods of biochemicaly re-search (lipid exchange and power machinery]. Izd-vo Leningrad. 1982;250. Russian.
Saatov TS, Abduvaliyev AA. [Biological effects of thyroid hormones]. Ukrai'ns'kyj biohimichnyj zhurnal. 2013;1:690-8. Ukrainian.
Tuchak AI, Emelianenko IV. [State of peroxide-oxidative processes in the body in experimental hypothy-roidism and the correction of "iodide-100"]. Ekspe-remental'na ta klinichna fiziologija i biohimija. 2007;40(4):7-9. Ukrainian.
Rumors LS, Surushkyna SY. [Panicheskoe ras-stroystvo. Klinicheskie osobennosti i podkhodі k leche-niyu]. Terapevticheskiy arkhiv. 2014;8:133-7. Russian.
Bagatolli LA, Ipsen JH, Simonsen AC, et al. An outlook on organization of lipids in membranes: Sear-ching for a realistic connection with the organization of biological membranes. Prog. Lipid Res. 2012;49:378-89.
Aksoy D.Y., Cinar N., Harmanci A, et al. Serum resestin and high sensitive CRP levels in patients with subclinical hypothyroidism before and after L-thyroxin therapy. J. Med. Sci. Monit. 2013;19(22):210-15.
Tata JR. Looking for the mechanism of action of thyroid hormone. Journal of Thyreoid Research. 2011;2:12.
##submission.downloads##
Опубліковано
Як цитувати
Номер
Розділ
Ліцензія
Авторське право (c) 2017 Медичні перспективи
Ця робота ліцензується відповідно до Creative Commons Attribution-NonCommercial 4.0 International License.
Submitting manuscript to the journal "Medicni perspektivi" the author(s) agree with transferring copyright from the author(s) to publisher (including photos, figures, tables, etc.) editor, reproducing materials of the manuscript in the journal, Internet, translation into other languages, export and import of the issue with the author’s article, spreading without limitation of their period of validity both on the territory of Ukraine and other countries. This and other mutual duties of the author and all co-authors separately and editorial board are secured by written agreement by special form to use the article, the sample of which is presented on the site.
Author signs a written agreement and sends it to Editorial Board simultaneously with submission of the manuscript.
