The influence of the hematological complications on the efficiency of the systemic therapy of breast cancer.

Анотація

The interest in studying the effect of haematological complications on survival of patients with solid tumors during chemotherapy has increased in recent years. The results of  various global studies are ambiguous and often opposite. The objectives of our study was to investigate the dynamics of hematological parameters during the course of chemotherapy, their impact on health outcomes and indicators of survival of patients. Retrospectively, medical records of 110 patients with inoperable breast cancer, who received palliative chemotherapy courses by the scheme taxanes + anthracyclines,were analyzed. Dynamics of neutrophils indicators, hemoglobin, platelets, tumor response according to RECIST criteria of 1.1., as well as the long-term outcomes were studied. It was found that the most intensivelylevel of hemoglobin reduced at the first cycle of treatment (81.1% of patients), later it stabilized (17.7-37.3%) (p<0.05). During the first treatment cycle neutropenia occursin 71.1-78.2% of patients, thrombocytopenia – in 3.6-5.55%. Later, thrombocytopenia rate reduced to 1.2-1.9%, neutropenia – to 58.3-63.5% (p<0.05). The presence of neutropenia causes significantly positive impact on the results of treatment of patients with metastatic breast cancer. In the presence of neutropenia during chemotherapy, indicators of general and disease-free survival arereliably higher.