The influence of intravenous solution «Neoreodez» on the course of experimental endotoxemia and evaluation of the regenerative properties of drug in the conditions of application.
DOI:
https://doi.org/10.26641/2307-0404.2016.3.81658Ключові слова:
solution «Neoreodez», detoxication, regenerative propertiesАнотація
In the experiment it was shown that experimental endotoxemia induced by introduction of carbon tetrachloride and bacterial lipopolysaccharide is characterized by activation of free radical oxidation and failure of antioxidant defense system. Intravenous injection of solution «Neoreodez» under these experimental conditions has a positive impact on the course of endogenous intoxication, which is manifested by decrease in the concentration of MDA and DC in the liver on average by 1½ times (p≤0.05), decrease in the level of AlAT and AsAT serum by 2 times (p≤0.05) and to restore the balanced functioning of antiradical protection – increased activity of SOD by 1.6 times (p<0.05) in comparison with the performance of the active control. It is established that two-week application «Neoreodez» of solution potentiate the processes of natural reparation of damaged skin.
Посилання
Hurevych VS. [A comparative analysis of the two methods for determining the activity of superoxide dis-mutase]. Lab. delo. 1990;4:44-47. Russian.
Dronov SN. [The detoxifying properties and acute toxicity of the fixed combination of a low-concentration solution of sodium hypochlorite and taurine, intended for parenteral use]. Pharmakolohiia i likarska toksykolohiia. 2014;4-5(40):32-39. Russian.
Dubovaia AV. [Exogenous and endogenous into-xication. Functional detoxification system]. Zdorove re-benka. 2011;5(32):93-96. Russian.
Kazymyrko VK, Mal'tsev VI. [Antioxidant sys-tem and its operation in the human body]. Zdorovia Ukrainy. 2007;5:15-24. Russian.
Lapach SN, Chubenko AV, Babich PN. [Statis-tical methods in biomedical research using EXCEL]. K.: «Moryon», 2001;408. Russian.
Miazyn RH. [The use of sodium hypochlorite for the treatment of patients with chronic diffuse liver diseases]. Monohrafyia, Volhohrad. 2010;118. Russian.
Kozhemiakin YuM, Khromov OS, Filonenko MA, Sairetdynova HA. [Scientific and practical advice on keeping laboratory animals and work with them]. K. 2002;155. Ukrainian.
Novochadov VV, Pisarev VB. [Endotoxicosis: mo¬deling and organopathology]. Volhohrad: Yzd-vo VolHMU. 2005;240. Russian.
Ivanov VK, Belen'kiy GZ, Snezhko ZI. [Patent №2488382, YiSh, MPK A61K. Desintoxication infusion solution "Neoreodez"]. 07.02.12, published 27.07.13. Russian.
[The statistical analysis program. WEB-resource]. Available frome: www.analystsoft.com/ru. Russian.
[Wound healing and antimicrobial agent. Russian patent RU 2317818. WEB-resource]. Available frome: www.fmdpatent.ru/patent/231/2317818.html. Russian.
Serhyenko VY, Petrosyan EA. [Sodium hypo-chlorite in the treatment of purulent wounds]. Vestnyk khyrurhyy.1991;2:40-43. Russian.
[Reference Laboratory Methods]. Danylovoi LA. SPb.: Pyter, 2003;736. Russian.
Fedorovskyi NM, Gostishchev VK, Dolina OA. [Methods of intravenous indirect electrochemical deto-xification in treatment of endogenous intoxication]. Vestnik intensivnoy terapii. 1993;1:31-33. Russian.
Shylova NA, Bitsunov NS. [Measurement of the blood acid-base status and glycosylated hemoglobin under the influence of sodium hypochlorite in diabetic coma ketoatsidoticheskaya]. Vestnik intensivnoy terapii. 1996;2:122. Russian.
Bustamante J, Lobo MV, Alonso FJ. [An osmo¬tic-sensitive taurine pool is localized in rat pancreatic islet cells containing glucagon and somatostatin]. Am J Physiol Endocrinol Metab. 2001;281(6):1275-85.
Das J, Vasan V, Sil PC. [Taurine exerts hypogly-cemic effect in alloxan-induced diabetic rats, improves insulin-mediated glucose transport signaling pathway in heart and ameliorates cardiac oxidative stress and apoptosis]. Toxicol. Appl. Pharmacol. 2012;258(2):296-308.
El Idrissi A, Trenkner E. [Taurine as a modulator of excitatory and inhibitory neurotransmission]. Neuro-chem Res. 2004;29(1):189-97.
##submission.downloads##
Опубліковано
Як цитувати
Номер
Розділ
Ліцензія
Авторське право (c) 2017 Медичні перспективи
Ця робота ліцензується відповідно до Creative Commons Attribution-NonCommercial 4.0 International License.
Submitting manuscript to the journal "Medicni perspektivi" the author(s) agree with transferring copyright from the author(s) to publisher (including photos, figures, tables, etc.) editor, reproducing materials of the manuscript in the journal, Internet, translation into other languages, export and import of the issue with the author’s article, spreading without limitation of their period of validity both on the territory of Ukraine and other countries. This and other mutual duties of the author and all co-authors separately and editorial board are secured by written agreement by special form to use the article, the sample of which is presented on the site.
Author signs a written agreement and sends it to Editorial Board simultaneously with submission of the manuscript.
