Comparative evaluation of bioprotective action of zinc in organic and inorganic form on osteotropism of lead in experimental conditions.
DOI:
https://doi.org/10.26641/2307-0404.2016.4.91481Ключові слова:
zinc, plumbum, calcium, osteoporosis, boneАнотація
Chemical aggression of technogenic pollution of the environment, according to experts, is the leading risk factor for population health. A systematic entry of contaminants in the related life-supporting environments – air, water, plant and animal food products by direct and indirect migration chains creates both integrated and combined effect on the body. It should be noted that a chemical factor, on the one hand, is the least studied in this respect, on the other hand it represents the most significant and rapidly growing environmental threat to human health. In the human body bone tissue has the highest cumulative properties against many xenobiotics, in particular to heavy metals, among which lead is the leader in relationship to the bone tissue. In this regard, the goal is to study peculiarities of different forms of zinc on calcium content in bone tissue in lead intoxication. As a result of researches it is established that low dosed effect of lead during subacute experience causes a significant decrease of calcium content in the bone tissue by 28% in comparison with those of control group of animals, this reduces its density and becomes a risk factor for the development of osteopenic and osteoporotic state of the organism. Combined effect of lead and organic and inorganic forms of zinc zeliably increases calcium content by 16.43% and 22,04% respectively, as compared with lead group, suggesting protective properties of zinc in lead intoxication due to the effect of bioantagonism. In the isolated introduction of organic and inorganic forms of zinc, calcium content in the bone tissue increases by 1.4 and 2.04 times respectively, as compared with the control group. The obtained results confirm osteoprotective action of zinc, particularly of organic forms in lead intoxication and give reason to believe that in the system "lead – zinc" effect of biological antagonism is formed.
Посилання
Antomonov MYu. [Mathematical processing and analysis of biomedical data]. Kiev, 2006;558. Russian.
Beletskaya EN, Golovkova TA, Onul NM. [Biological prevention of ecologically dependent con-ditions in the population of industrialized territories]. Ak-tual'nye problemy transportnoy meditsiny. 2011;3(2):48-56. Russian.
Beletskaya EN, Onul NM, Bezub OV. [Hygienic aspects of osteotropism of lead as a risk factor cal-ciomercato pathology in humans (literature review)]. Medicnі perspektivi. 2014;19(2):130-9. Russian.
[GOST 26570-95 Interstate standard. Feed, mixed fodders, feed raw materials. Methods for the deter-mination of calcium]. Russian. 5. Ershov YuA, Pletneva TV. [Mechanisms of toxic action of inorganic compounds]. Moskva: Meditsina, 1989;272. Russian.
Kutsenko SA. [Fundamentals of toxicology]. Sankt-Peterburg, 2002;395. Russian.
Pіshak VV, Visots'ka VG, Magalyas VM. [Labo-ratory animals in biomedical experiments]. Chernіvtsі: Med. un-t, 2006;350. Ukrainian.
Antonovich EA, Kagan YuS, Spynu EI. [Metho-dical instructions on hygienic evaluation of new pes-ticides]. Ministerstvo zdravookhraneniya SSSR; VNII gigieny i toksikologii pestitsidov, polimerov i plasti-cheskikh mass. Kiev; 1988. Russian.
Allen LH. Food Safety: Heavy Metals. Ency-clopedia of Human Nutrition. Third Edition. 2013;331-6.
González-Estecha M, Trasobares E, Fuentes M. Blood lead and cadmium levels in a six hospital employee population. PESA study, 2009. J Trace Elem Med Biol. 2011;25:22-29.
Boscolo P, Carmignani M. Neurohumoral blood pressure regulation in lead exposure. Environ Health Perspect. 1988;78:101-6.
Bushak L. China tops WHO list for deadly outdoor air pollution. WHO.-2016 . Available from: https://www.theguardian.com/environment/2016/sep/27/more-than-million-died-due-air-pollution-china-one-year
Lu H, Yuan G, Yin Z. Effects of subchronic exposure to lead acetate and cadmium chloride on rat’s bone: Ca and Pi contents, bone density, and histo¬patho-logical evaluation. Int J Clin Exp Pathol. 2014;7:640-7.
Kupraszewicz E, Brzóska MM. Excessive ethanol consumption under exposure to lead intensifies disorders in bone metabolism: A study in a rat model. Chem Biol Interact. 2013;203:486-501.
Moser-Veillon RB. Zinc needs and homeostasis during lactation. Analyst. 1995;120:895-7.
Persicov АV, Brodsky B. Unstable molecules form stable tissues. Proc. Natl. Acad. Sci. 2002;99(3):1101-3.
Boscolo P, Galli G, Iannaccone A. Plasma renin activity and urinary kallikrein excretion in lead-exposed workers as related to hypertension and nephropathy. Life Sci. 1981;28:175-84.
Dai S, Yin Z, Yuan G. Quantification of metal-lothionein on the liver and kidney of rats by subchronic lead and cadmium in combination. Environ Toxicol Pharmacol. 2013;36:1207-16.
Schoenau E, Frost HM. The "Muscle-Bone-Unit" in Children and Adolescents. Calcif Tissue Int. 2002;70:405-7.
##submission.downloads##
Опубліковано
Як цитувати
Номер
Розділ
Ліцензія
Авторське право (c) 2017 Медичні перспективи
Ця робота ліцензується відповідно до Creative Commons Attribution-NonCommercial 4.0 International License.
Submitting manuscript to the journal "Medicni perspektivi" the author(s) agree with transferring copyright from the author(s) to publisher (including photos, figures, tables, etc.) editor, reproducing materials of the manuscript in the journal, Internet, translation into other languages, export and import of the issue with the author’s article, spreading without limitation of their period of validity both on the territory of Ukraine and other countries. This and other mutual duties of the author and all co-authors separately and editorial board are secured by written agreement by special form to use the article, the sample of which is presented on the site.
Author signs a written agreement and sends it to Editorial Board simultaneously with submission of the manuscript.
