A comparative analysis of european and german pharmacopoeias requirements to the "bitterness value" test
DOI:
https://doi.org/10.15587/2313-8416.2016.67687Keywords:
centaury herb, "Bitterness value" test, sekoiridoid glycosides (bitters), European pharmacopoeia, German pharmacopoeia, State Pharmacopoeia of UkraineAbstract
A comparative analysis of European (PhEur 8.4) and «Tausendgüldenkraut» German (DAB 10) pharmacopoeias requirements to the "Bitterness value" test was carried out. It has been shown, that the results of research of 21 series of centaury herb, collected in different regions of Ukraine, meets the PhEur 8.4 requirements "Bitterness value" and are characterized by poor convergence of results.
Aim. The aim of our research was to compare PhEur 8.4 and DAB 10 requirements to the "Bitterness value" test, and to substantiate the choice of method according to the PhEur requirements.
Methods. 2.8.15. "Bitterness value" test, described in 2.8. “Pharmacognosy methods” chapter (PhEur/SPhU), which allows determining general bitters content in herbal material.
Results. Bitters content in 21 series of centaury herb was determined. Results of research show that the analyzed samples of centaury herb meet the requirements of PhEur 8.4. Monograph "Bitterness value".
Conclusion. National samples of centaury herb study in terms of "Bitterness value" according to the «Centaury» PhEur 8.4. and «Tausendgüldenkraut» DAB 10 Monographs requirements was carried out. A comparative analysis of the normative documents has shown that the "Bitterness value" test is rational to carry out in accordance to 2.8.15. "Bitterness value" PhEur 8.4/SPhU. The given method is based on subjective assessment and sensitivity of experts’ taste receptors, which can lead to poor convergence of results of bitters content determination by different expertsReferences
Sinjakova, L. A., Kosova, I. V. (2009). Profilaktika recidivov infekcij mochevyh putej. Urologija, 2, 22–25.
Perepanova, T. S., Hazan, P. L. (2005). Rastitel'nyj preparat Kanefron®N v lechenii i profilaktike infekcij mochevyh putej. Vrachebnoe soslovie, 5, 44–46.
Kalinina, S. N., Tiktinskij, O. L., Semenov, V. A. et. al (2006). Rol' Kanefrona®N pri lechenii hronicheskogo pielonefrita i profilaktike ego oslozhnenij. Urologija, 1, 22–25.
Kunle, O. F. (2012). Standardization of herbal medicines – A review. International Journal of Biodiversity and Conservation, 4 (3), 101–112. doi: 10.5897/ijbc11.163
Ahmed, E., Alaa, M. N., Mohamed, A. E. et. al (2015). New secoiridoid ester of swertiamarin and secoxyloganic acid with hepatoprotective activity from Centaurium spicatum L. Journal of Pharmacy & Pharmacognosy Research, 3 (3), 69–76.
Munir, A., Mansoor, A., Muhammad, A. et. al (1996). Enicostema littorale: A new source of swertiamarin. Pakistan Journal of Pharmaceutical Sciences, 9 (1), 29–35.
Jerković, I., Gašo-Sokač, D., Pavlović, H., Marijanović, Z., Gugić, M., Petrović, I., Kovač, S. (2012). Volatile Organic Compounds from Centaurium erythraea Rafn (Croatia) and the Antimicrobial Potential of Its Essential Oil. Molecules, 17 (12), 2058–2072. doi: 10.3390/molecules17022058
Aberhama, A., Pieri, V., Croom, E. M., Ellmerer, E., Stuppner, H. (2011). Analysis of iridoids, secoiridoids and xanthones in Centaurium erythraea, Frasera caroliniensis and Gentiana lutea using LC–MS and RP-HPLC. Journal of Pharmaceutical and Biomedical Analysis, 54 (3), 517–525. doi: 10.1016/j.jpba.2010.09.030
Pokaznyk girkoty (2.8.15). Derzhavna Farmakopeja Ukrai'ny. Vol. 1 (2015). Kharkiv: DP «Ukrai'ns'kyj naukovyj farmakopejnyj centr jakosti likars'kyh zasobiv», 384.
European Pharmacopoeia (2015). Strasbourg: European Department for the Quality of Medicines.
Tausendgüldenkraut. DAB 10. Kommentar (1991). Stuttgart: Wissenschaftliche Verlagsgesellshaft, 152.
Kommentar zum DAB 10 (1991). V.4.4.N1 Bestimmung des Bitterwertes». Grundlfg.
Sur, S., Grycenko, O. (2002). Problemy ta perspektyvy rozrobky i vprovadzhennja suchasnyh likars'kyh zasobiv roslynnogo pohodzhennja. Liky Ukrai'ny, 4, 47–49.
Herbal Drugs and Phytopharmaceuticals (1994). Medpharm Scientific Publishers. Stuttgart, 566.
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