Metabolic role of connective tissue in the development of pathological processes of different intensity in the stomach
DOI:
https://doi.org/10.15587/2313-8416.2015.37581Keywords:
connective tissue metabolism, degradation, biosynthesis of collagen, hydroxyproline, the stomach, the severity of the pathological processAbstract
Aim: To study changes in exchange of connective tissue at development of pathological process in a stomach.
Methods: Patients with inflammatory processes in a stomach of various severity and cancer patients were examined. Groups were created so that weight of pathological process in a stomach and risks for health increased from group to group. 5 groups on 50 people were surveyed. In each of groups the CEA level, and the level of various fractions of hydroxyproline was defined.
Results: It was revealed that the CEA levels, free- and peptide-bound hydroxyproline levels were more in groups with higher severity of pathological process. But the levels of the protein-bound hydroxyproline were less in the same groups. It is possible to assume that it is connected with growth of extent of degradation of CT in process of increase of severity of pathological process. Increasing the severity of the pathological process above a certain level causes disbalance in system of CT. It can reflect failure of adaptation in system of CT, and may be one of factors of irreversibility (chronization) of pathological process.
Conclusion: The connective tissue is essentially involved in pathological processes in a stomach. At a superficial inflammation processes of synthesis and degradation of collagen are in some balance, and the increase in severity of pathological process leads to violation of this balance
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