Functional activity of the adrenal glands and abdominal obesity index as markers of dyslipidemia in patients with diabetes mellitus type 2
DOI:
https://doi.org/10.15587/2313-8416.2015.52261Keywords:
obesity, diabetes mellitus type 2, corticosteroids, cortisol, DHEA, visceral obesity index, dyslipidemiaAbstract
Cortisol and DHEA disbalance that appears in patients with diabetes mellitus type 2 leads to certain metabolic changes especially hyperglycemia, dyslipidemia, accumulation of abdominal fats, increase of proteins decay.
Aim. The study of correlations between cortisol/DHEA ratio, constitutional parameters (degree of obesity, character of fat distribution), abdominal obesity index, rates of blood lipid spectrum in patients with diabetes mellitus (DM) type 2.
Methods. For this aim there were examined 19 patients with DM type 2. There were used general clinical (body mass, height, waist and hips size, body mass and visceral obesity indices), biochemical (glycemia level, blood serum lipid spectrum rates), hormonal (C-peptide, cortisol, dehydroepiandrosterone sulfate) and statistical (Student criterion) methods of research.
Results. There was established that increase of cortisol/DHEA ratio rate is followed with growth of glycemia and glycated hemoglobin ( HbA1c) levels and also has a negative influence on blood serum lipid spectrum, that is favors an increase of triglycerindes, atherogenic fractions of cholesterol lipoproteins of the low density (LPLD) and lipoproteins of the very low density (LPVLD) concentration, decrease of anti-atherogenic lipoproteins of the high density (LPHD) content at the stable C-peptide level. The aforesaid negative processes took place simultaneously with the changes of visceral obesity index (VOI) that includes both the character of distribution and the function of adipose tissue.
Conclusion. Calculation of VOI in patients with diabetes mellitus type 2 as the marker of lipid metabolism disorder and stress/anti-stress corticosteroid disbalance is useful and reasonable
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