Щодо значення окремих генотипових характеристик для формування бронхіальної астми фізичної напруги у дітей
DOI :
https://doi.org/10.15587/2313-8416.2015.51274Mots-clés :
діти, бронхіальна астма фізичної напруги, лабільність бронхів, гени глутатіонтрансферази, NO-синтазиRésumé
В роботі досліджено значення делеційного поліморфізму генів GSTT1 та GSTM1 та мутацій гену еNOS у формуванні лабільності бронхів у дітей, хворих на бронхіальну астму фізичної напруги. У дітей із бронхіальною астмою фізичного зусилля частіше виявляється «нульовий» генотип генів GSTT1 та GSTM1, показники бронхоспазму найвищі у пацієнтів з генотипом GSTT1delM1+. У кожної другої дитини, хворої на бронхіальну астму, трапляються мутації гену еNOS
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