The analysis of blood coagulation changes in patients with hypertension in combination with chronic obstructive pulmonary disease varying degrees of severity
DOI:
https://doi.org/10.15587/2519-4798.2017.100358Keywords:
hypertension, chronic obstructive pulmonary disease, coagulation hemostasis, snake venomAbstract
Aim of research was to determine the influence of COPD severity on the plasma hemostasis condition in patients with HT combined with COPD.
Materials and methods. 79 patients were examined: 15 almost healthy (control) and 64 patients with stage II HT with concomitant COPD. Depending on the COPD severity, the patients were divided into 3 groups: group A- 11 patients with HT and COPD of the I severity degree; Group B - 28 patients with HT and COPD of the II severity degree; Group B - 25 patients HT and COPD of the III severity degree. Special laboratory tests: coagulation indicators - activated partial thromboplastin time, prothrombin time, thrombin time, fibrinogen, soluble fibrin monomer complexes, ancistron test, Lebetox test, and echitox test were carried out.
Results: in result of the study it was found that comorbid HT and COPD course is characterized by increased activity of hemostasis system coagulation level, which intensity is associated with bronchial obstruction severity. In particular, COPD of the III severity degree hyperfibrinogenemia, as well as soluble fibrin monomer complexes significant increase were observed in all subgroups of the patients with HT and COPD, accompanied by activation of external pathway of coagulation and combined with accelerated processes of prothrombinase-, trombino- and fibrin formation according to specific snake venoms tests.
Conclusion. Comorbid HT and COPD course is characterized by the activation of hemostasis system coagulation level, which intensity is associated with bronchial obstruction severity. Hyperfibrinogenemia and a significant increase of the SFMC content, observed in all subgroups of the patients with HT and COPD, at COPD of the III severity degree are accompanied by activation of external pathway of coagulation and combined with accelerated processes of prothrombinase-, trombino- and fibrin formation according to specific snake venoms tests. The patients with HT combined with COPD of the III severity degree need careful laboratory monitoring to solve the problem of the additional antithrombotic correction necessityReferences
- Pastukhov, M. V. (2015). Statistical Review and ways progression of COPD in Ukraine. Ukrainian Scientific Medical Youth Journal, 1, 136–137.
- Korotchenko, О. V. (2014). Current international recommendations on the diagnosis of chronic obstructive pulmonary disease according to the Global Initiative for the diagnosis and treatment of COPD (GOLD) GOLD 2011 with amendments 2012. Therapeutic Ukrainian magazine, 2, 5–9.
- Stupnytskyi, G. Y. (2014). The state of hemostasis in chronic obstructive pulmonary disease, combined with obesity. Stupnytskyi circulation and hemostasis, 1-2, 119–122.
- Rasputin, L. V. (2010). Features of clinical course of hypertension in patients with chronic obstructive pulmonary disease. Actual problems of modern medicine, 10 (2), 96–99.
- Medvedev, I. N. (2015). Aggregational properties of blood elements and vascular control over them in patients with arterial hypertension with dyslipidemia. Russian Cardiology Journal, 4, 18–22.
- Roka-Moya, Y. M., Bilous, V. L., Zhernossekov, D. D., Grinenko, T. V. (2014). Novel aspects of platelet aggregation. Biopolymers and Cell, 30 (1), 10–15. doi: 10.7124/bc.000874
- Ikeda, N., Yasu, T., Tsuboi, K., Sugawara, Y., Kubo, N., Umemoto, T. et. al. (2010). Effects of Submaximal Exercise on Blood Rheology and Sympathetic Nerve Activity. Circulation Journal, 74 (4), 730–734. doi: 10.1253/circj.cj-09-0758
- Samoilova, S. O., Plienova, O. M. (2016). Determination of coagulation factors activity in patients with II stage hypertension in combination with COPD using highly specific tests containing snake venom. ScienceRise: Medical Science, 6 (2), 4–9. doi: 10.15587/2519-4798.2016.72549
- Samoilova, S. O. (2016). Effect of concomitant chronic obstructive pulmonary disease on blood clotting in patients with stage II hypertension. Family Medicine, 4 (66), 146–149.
- Order "On approval and introduction of medical and technological documents and standardization of medical care in hypertension" (2012). Ministry of Health of Ukraine, No. 384.
- Order "On Amendments to the Ministry of Health of Ukraine" (2014). Ministry of Health of Ukraine, No. 270.
- Barkagan, Z. S., Momot, A. P. (2001). Diagnosis and therapy controlled hemostasis disorders. Moscow: Nyudiamed, 296.
- Kravchenko, N. K., Vovk, T. B., Raksha, N. G., Savchuk, O. M., Ostapchenko, L. I. (2015). The systems approach to the study of protein-protein interactions in disorders of hemostasis. Kyiv: "TOV "Interservice", 194.
- Kim, V., Goel, N., Gangar, J., Zhao, H., Ciccolella, D., Silverman, E. et. al. (2014). Risk Factors for Venous Thromboembolism in Chronic Obstructive Pulmonary Disease. Chronic Obstructive Pulmonary Diseases: Journal of the COPD Foundation, 1 (2), 239–249. doi: 10.15326/jcopdf.1.2.2014.0133
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