Evaluation of life quality in patients with postinfarction cardiosclehrosis on the background of metabolitic therapy

Authors

DOI:

https://doi.org/10.15587/2519-4798.2017.109226

Keywords:

life quality, ischemic heart disease, postinfarction cardiosclerosis, metabolic therapy, glutargin, MacNew

Abstract

Aim of research – to estimate the dynamics of life quality indices in patients with postinfarction cardiosclerosis on the background of the metabolic therapy using the questionnaire MacNew Heart Disease Health-related Quality of Life.

Materials and methods: in the research took part 99 patients (71 % of men and 29 % of women) with postinfarction cardiosclerosis, stable angina of effort of ІІ-ІІІ functional class. Patients of the group of comparison (n=49) continued to take the basis therapy of the ischemic heart disease, whereas patients of the main group (n=50) additionally took glutargin. All groups were representative by age and sex. The patients’ life quality estimation was realized by the questionnaire MacNew.

Results: The determination of the life quality was carried out using the questionnaire MacNew Heart Disease Health-related Quality of Life, most effective for patients with the ischemic heart disease. At the comparative analysis of initial life quality indices by the questionnaire MacNew in both groups, all patients with postinfarction cardiosclerosis demonstrated the decrease of all indices of scales and didn’t differ statistically. It was established, that on the background of glutargin treatment took place the statistically reliable increment of the physical activity (from 4,3±1,0 to 5,2±0,9 points, p<0,05) and reliable increase of the routine activity, limited by the pain influence (from 4,6±0,8 to 5,9±0,9 points, p<0,05).

Conclusions: All patients with postinfarction cardiosclerosis demonstrated the essential decrease of life quality indices in physical, emotional and social spheres. Glutargin inclusion into the standard therapy of patients with the ischemic heart disease allows to improve the life quality of patients with postinfarction cardiosclerosis essentially

Author Biographies

Svitlana Semenchuk, Vinnytsia National Pirogov Memorial Medical University Pyrohova str., 56, Vinnytsia, Ukraine, 21018

Postgraduate student

Department of Clinical Pharmacy and Clinical Pharmacology

Tamara Stotska, Trade-Union sanatorium "Khmilnyk" Kurortna str., 2, Khmilnyk, Vinnytsia region, Ukraine, 22003

Head of department

Department of rehabilitation of postinfarction patients

References

  1. Handzyuk, V. A. (2014). Analiz zakhvoryuvanosti na ishemichnu khvorobu sertsya v Ukrayini [Analysis of the incidence of ischemic heart disease in Ukraine]. Ukrainian Journal of Cardiology, 3, 45–52.
  2. Surmach, M. Yu. (2011). Kachestvo zhizni, svyazannoye so zdorov'yem, kak predmet izucheniya sotsiologii meditsiny [Health-related quality of life as the study object of medical sociology]. Sociology, 2, 100–104.
  3. Krom, I. L., Erugina, M. V., Sazanova, G. Yu. (2015). Vektory optimizatsii kachestva zhizni bol'nykh ishemicheskoy bolezn'yu serdtsa [Vectors for optimizing the quality of life of patients with ischemic heart disease]. Saratov Scientific Medical Journal, 1, 62–65.
  4. Pogosova, N. V., Baichorov, I. Kh., Yufereva, Yu. M., Koltunov, I. E. (2010). Kachestvo zhizni bol'nykh s serdechno-sosudistymi zabolevaniyami: sovremennoye sostoyaniye problem [Quality of life of patients with cardiovascular diseases: current status of the problem]. Cardiology, 50 (4), 66–78.
  5. Yagenskiy, A. V., Hofer, S., Sichkaruk, I. M., Oldridge, N. (2013). Otsinka yakosti zhyttya u patsiyentiv z ishemichnoyu khvoroboyu sertsya: rezulʹtaty validyzatsiyi ukrayinomovnoyi versiyi opytuvalʹnyka MacNew Heart Disease Health-related Quality of Life [Quality of life assessment in patients with ischemic heart disease: validation of Ukrainian-language version of MacNew Heart Disease Health-related Quality of Life]. Ukrainian journal of cardiology, 3, 22–28.
  6. Oldridge, N., Hofer, S., McGee, H., Conroy, R., Doyle, F., Saner, H. (2012). The HeartQoL: Part I. Development of a new core health-related quality of life questionnaire for patients with ischemic heart disease. European Journal of Preventive Cardiology, 21 (1), 90–97. doi: 10.1177/2047487312450544
  7. Babak, O. Ya. (2005). Glutargin – farmakologicheskoye deystviye i klinicheskoye primeneniye [Glutargin – pharmacological action and clinical application]. Kharkiv–Lugansk: Elton-2, 456.
  8. Schlesinger, S., Sonntag, S. R., Lieb, W., Maas, R. (2016). Asymmetric and Symmetric Dimethylarginine as Risk Markers for Total Mortality and Cardiovascular Outcomes: A Systematic Review and Meta-Analysis of Prospective Studies. PLOS ONE, 11 (11), e0165811. doi: 10.1371/journal.pone.0165811
  9. Tain, Y.-L., Hsu, C.-N. (2017). Interplay between Oxidative Stress and Nutrient Sensing Signaling in the Developmental Origins of Cardiovascular Disease. International Journal of Molecular Sciences, 18 (4), 841. doi: 10.3390/ijms18040841
  10. Kanaan, G. N., Harper, M.-E. (2017). Cellular redox dysfunction in the development of cardiovascular diseases. Biochimica et Biophysica Acta (BBA) – General Subjects. doi: 10.1016/j.bbagen.2017.07.027
  11. Zhang, J. X., Wang, Z. M., Zhang, J. J., Zhu, L. L., Gao, X. F., Chen, S. L. (2014). Association of glutathione peroxidase-1 (GPx-1) rs1050450 Pro198Leu and Pro197Leu polymorphisms with cardiovascular risk: a meta-analysis of observational studies. Journal of Geriatric Cardiology, 11 (2), 141–150.
  12. Indyka, S. Ya. (2012). Poshyrenist depresiyi ta zvyazok z inshymy faktoramy ryzyku sertsevo-sudynnykh zakhvoryuvan u patsiyentiv pislya infarktu miokarda na ambulatornomu etapi reabilitatsiyi [Prevalence of Depression and Relationship with Other Risk Factors for Cardiovascular Diseases Among Patients After Myocardial Infarction in Ambulatory Stage of Rehabilitation]. Physical education, sports and health culture in modern society, 4 (20), 369–372.

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Published

2017-08-31

How to Cite

Semenchuk, S., & Stotska, T. (2017). Evaluation of life quality in patients with postinfarction cardiosclehrosis on the background of metabolitic therapy. ScienceRise: Medical Science, (8 (16), 42–44. https://doi.org/10.15587/2519-4798.2017.109226

Issue

No. 8 (16) (2017)

Section

Medical Science

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Copyright (c) 2017 Svitlana Semenchuk, Tamara Stotska

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