Effect of atorvastatin on clinical manifestations of gout comorbid with arterial hypertension

Authors

DOI:

https://doi.org/10.15587/2519-4798.2017.113499

Keywords:

gout, arterial hypertension, clinical course, pleitropic effects, anti-inflammatory action, atorvastatin

Abstract

Aim of the work was to determine a possible effect of atorvastatin on clinical symptoms of gout, comorbid with arterial hypertension.

Materials and methods: 56 patients of middle age with gout and arterial hypertension were divided in groups of the standard treatment (n=26) and one with additional atorvastatin in 20 mg/day (n=30), the observation period was 43±9 days.

Results: There were observed the significant decrease of hyperemia of injured articulations (р=0,03 for metatarsophalangeal articulations), insignificant decrease of the circle (р=0,17), increase of motility of involved articulations (р=0,19), compared with the control group, and wasn’t revealed any influence on the pain intensity by VAS and on clinical manifestations of arterial hypertension or office arterial pressure.

Conclusion: atorvastatin addition to the standard gout therapy and arterial hypertension has the moderate anti-inflammatory effect, without influencing the pain intensity, arterial pressure and clinical manifestations of arterial hypertension

Author Biographies

Natalya Zolotariova, Odessa National Medical University Valykhovskyi lane, 2, Odessa, Ukraine, 65082

MD, Professor, Head of the Department

Department  of Internal Medicine No. 4

Maksym Romanchenko, Odessa National Medical University Valykhovskyi lane, 2, Odessa, Ukraine, 65082

Assistant

Department of Internal Medicine No. 4

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Published

2017-10-31

How to Cite

Zolotariova, N., & Romanchenko, M. (2017). Effect of atorvastatin on clinical manifestations of gout comorbid with arterial hypertension. ScienceRise: Medical Science, (10 (18), 39–44. https://doi.org/10.15587/2519-4798.2017.113499

Issue

No. 10 (18) (2017)

Section

Medical Science

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Copyright (c) 2017 Natalya Zolotariova, Maksym Romanchenko

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