Dynamics of indicators of oxidative stress and bone metabolism during treatment with thiotriazolin in patients with combined type 2 diabetes mellitus and osteoporosis course who reside in anthropogenic pressure conditions
DOI:
https://doi.org/10.15587/2519-4798.2019.155320Keywords:
thiotriazolin, oxidative stress, bone metabolism, type 2 diabetes mellitus, osteoporosisAbstract
The aim of the study. To investigate the effect of thiotriazolin on oxidative stress and bone metabolism in patients with a combined course of type 2 diabetes and osteoporosis, who permanently reside in industrial region.
Materials and methods. On the basis of the educational and scientific medical center "University Hospital" of Zaporizhzhia State Medical University, 44 patients with combined course of type 2 diabetes and osteoporosis, who permanently resided in Zaporizhzhia, were examined for the period from 2016–2017. 22 patients received standard basic therapy for type 2 diabetes and osteoporosis, and 22 patients additionally received thiotriazolin. Patient groups were comparable in age, sex, and duration of type 2 diabetes mellitus. All patients studied the concentration of markers of oxidative stress (nitrotyrosine, 8-hydroxyguanine) and bone metabolism (osteocalcin and deoxypyridinoline).
Results. Patients with a combined course of type 2 diabetes mellitus and osteoporosis who received basic therapy with thiotriazolin supplementation registered a significant decrease in the concentration of oxidative stress. Thus, in patients of the second group, there was a significant decrease in the serum level of nitrotyrosine by 5.5 times (p<0.05) and 8-hydroxyguanine by 2.1 times (p<0.05). When evaluating markers of bone metabolism in patients of the second group, the level of osteocalcin increased by 24 % (p<0.05), and the concentration of deoxypyridinoline significantly decreased in individuals of both groups, but in the group with the addition of thiotriazolin, its rate decreased by 30%, and in the first group only 16 % (p<0.05).
Conclusions. In patients with a combined course of type 2 diabetes and osteoporosis, which, in addition to basic therapy, thiotriazolin was included, a significant decrease in markers of oxidative stress was registered in a daily dose of 600 mg for 3 months. Under the influence of basic therapy with the addition of thiotrazoline, a significant increase in bone formation and a decrease in bone resorption were observed in patients with a combined course of type 2 diabetes and osteoporosis
References
- Raška, I., Rašková, M., Zikán, V., Škrha, J. (2017). Prevalence and Risk Factors of Osteoporosis in Postmenopausal Women with Type 2 Diabetes Mellitus. Central European Journal of Public Health, 25 (1), 3–10. doi: http://doi.org/10.21101/cejph.a4717
- Yamagishi, S. (2011). Role of Advanced Glycation End Products (AGEs) in Osteoporosis in Diabetes. Current Drug Targets, 12 (14), 2096–2102. doi: http://doi.org/10.2174/138945011798829456
- Nagornaya, N. V., Chetverik, N. V. (2010). Oksidativnyi stress: vliyaniye na organizm cheloveka, metody otsenki [Oxidative stress: effect on the human body, assessment methods]. Zdorov'ye rebenka, 2 (23), 140–145.
- Mytnik, Z. N., Kolesnik, M. Yu. (2010). Tiotriazolin – gordost' otechestvennoy meditsiny i farmatsii [Thiotriazoline – the pride of native medicine and pharmacy]. Zaporozhskiy meditsinskiy zhurnal, 5 (12), 7–9.
- Prykhodʹko, V. Yu., Mykropulo, Y. R., Maslennykova, N. A. (2011). Metabolycheskaya terapyya v klynycheskoy praktyke: vybor optymalʹnoho preparata. [Metabolic therapy in clinical practice: the choice of the optimal drug]. Suchasni preparaty ta tekhnolohiyi, 1 (77), 80–85.
- Chekman, I. S., Belenichev, I. F., Gorchakova, N. A., Kucherenko, L. I., Bukhtiyarova, N. V., Pogotova, G. A. (2014). Antioksidanty: kliniko-farmakologicheskiy aspect [Antioxidants: Clinical and Pharmacological Aspect]. Ukrains'kiy medichniy chasopis, 1, 22–28.
- Gennari, L., Merlotti, D., Valenti, R., Ceccarelli, E., Ruvio, M., Pietrini, M. G. et. al. (2012). Circulating Sclerostin Levels and Bone Turnover in Type 1 and Type 2 Diabetes. The Journal of Clinical Endocrinology & Metabolism, 97 (5), 1737–1744. doi: http://doi.org/10.1210/jc.2011-2958
- Official Positions of The International Society for Clinical Densitometry – 2015 (2015). Available at: https://iscd.app.box.com/v/OP-ISCD-2015-Adult
- Makurina, G. I. (2015) Nitroziruyushchiy stress pri psoriaticheskoy bolezni v sochetanii s essentsial'noy gipertenziyey [Nitrosative Stress in Psoriatic Diseases Combined with Essential Hypertension]. Vestnik problem biologii i meditsiny, 3, 159–165.
- Pesta, D., Roden, M. (2017). The Janus Head of Oxidative Stress in Metabolic Diseases and During Physical Exercise. Current Diabetes Reports, 17 (6). doi: http://doi.org/10.1007/s11892-017-0867-2
- Zaytseva, O. V., Shandarenko, S. H., Velykyy, M. M. (2015). Vplyv nitrozatyvnoho stresu na mineralʹnyy metabolizm kistkovoyi tkanyny shchuriv za umov alimentarnoho osteoporozu [Influence of nitrosatitative stress on the mineral metabolism of bone tissue of rats under conditions of alimentary osteoporosis]. Medychna ta klinichna khimiya, 17 (1), 5–11.
- Belenіchev, І. F., Mazur, І. A., Voloshin, M. A., Gorchakova, N. O., Chekman, І. S. (2008). Mekhanіzm energotropnoi ta antioksidantnoi dіi tіotriazolіnu // Novosti meditsiny i farmatsii, 13-14 (249–250). Available at: http://www.mif-ua.com/archive/article/5699
- Effect of 1-year dietary supplementation with vitaminized olive oil on markers of bone turnover and oxidative stress in healthy post-menopausal women / Mazzanti L. et. al. // Endocrine. 2015. Vol. 50, Issue 2. P. 326–334. doi: http://doi.org/10.1007/s12020-015-0529-6
- Sandukji, A., Al-Sawaf, H., Mohamadin, A., Alrashidi, Y., Sheweita, S. (2010). Oxidative stress and bone markers in plasma of patients with long-bone fixative surgery: Role of antioxidants. Human & Experimental Toxicology, 30 (6), 435–442. doi: http://doi.org/10.1177/0960327110374203
- Khopta, N. S. (2010). Zastosuvannya preparatu «artyshoka ekstrakt-zdorovʺya» dlya korektsiyi porushenʹ kistkovoho metabolizmu za umov diyi ksenobiotykiv [Application of the drug "artichoke extract-health" for correction of bone metabolism disorders under the conditions of xenobiotics]. Klinichna ta eksperymentalʹna medytsyna, 4 (90), 161–165.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2019 Vitaliy Kryvenko, Olga Borodavko
This work is licensed under a Creative Commons Attribution 4.0 International License.
Our journal abides by the Creative Commons CC BY copyright rights and permissions for open access journals.
Authors, who are published in this journal, agree to the following conditions:
1. The authors reserve the right to authorship of the work and pass the first publication right of this work to the journal under the terms of a Creative Commons CC BY, which allows others to freely distribute the published research with the obligatory reference to the authors of the original work and the first publication of the work in this journal.
2. The authors have the right to conclude separate supplement agreements that relate to non-exclusive work distribution in the form in which it has been published by the journal (for example, to upload the work to the online storage of the journal or publish it as part of a monograph), provided that the reference to the first publication of the work in this journal is included.