Undifferentiated connective tissue dysplasia as a predictor of heart rate disorders in combination with gastroesophageal reflux disease in children

Authors

DOI:

https://doi.org/10.15587/2519-4798.2021.238132

Keywords:

undifferentiated connective tissue dysplasia, gastroesophageal reflux disease, arrhythmias, children, predictor

Abstract

The aim: to improve the early diagnosis of arrhythmia in combination with gastroesophageal reflux disease (GERD) in children, by studying the risk of connective tissue dysplasia on the occurrence of this pathology.

Materials and methods. We examined 100 children aged 8 to 18 years, mean age 13.7±2.7 years, of which 32 children with arrhythmias without combined pathology were group I, 36 children with concomitant GERD - group II and 32 children with GERD without concomitant arrhythmias - group III. Patients underwent clinical and instrumental studies (electrocardiography, Holter daily ECG monitoring, esophagogastroduodenoscopy and pH-metry) and evaluation of phenotypic signs of NDST according to the criteria of T. Milkovskaya-Dimitrova and A. Karkasho.

Results. A risk factor for the formation of combined pathology in children in the form of arrhythmia and GERD was identified, namely the next main phenotypic feature of NDST (undifferentiated connective tissue dysplasia) – dysplastic tooth growth.

Also, predictors of both an isolated variant of arrhythmia in children and arrhythmia in combination with GERD – high height and scoliotic posture were identified.

In this case, the risk factor for an isolated variant of arrhythmia in children, according to the results of the study is asthenic constitution.

The severity of NDST in the studied groups was determined. The analysis of the results revealed the absence of a statistically significant relationship between the severity of NDST and study groups, although it should be noted that in children of group III the first degree of NDST was not observed in general.

Conclusions. It was found that asthenic constitution, dysplastic tooth growth, tall stature and scoliotic posture are statistically significant risk factors for the development of the studied pathologies.

There were no statistically significant differences between the study groups regarding the severity of NDST, but there was a complete lack of detection in children of group III (children with isolated GERD without concomitant arrhythmia) of the first degree of NDST

Author Biographies

Oksana Herasymova, Kharkіv Medical Academy of Postgraduate Education

Postgraduate Student

Department of Pediatrics

Tetiana Filonova, Kharkіv Medical Academy of Postgraduate Education

PhD, Аssistant Professor

Department of Pediatrics

References

  1. Skirda, I. Y., Petishko, O. P., Zavgorodnyaya, N. Y. (2017). Epidemiological features of diseases of the digestive system in children and adolescents in Ukraine. Gastroenterology, 51 (4), 229–236. doi: http://doi.org/10.22141/2308-2097.51.4.2017.119287
  2. Yang, A., Kang, B., Choe, J. Y., Kim, H. S., Kim, K., Choe, Y. H. (2017). Prevalence and Epidemiological Characteristics of Endoscopically Proven Reflux Esophagitis in Children in Korea. Pediatric Gastroenterology, Hepatology & Nutrition, 20 (3), 160–166. doi: http://doi.org/10.5223/pghn.2017.20.3.160
  3. Melnyk, O., Samoilenko, I., Ptyshnyk, I. (2021). Problema hastroezofahealnoi refliuksnoi khvoroby u nemovliat ta ditei shkilnoho viku. Hraal Nauky, 2-3, 583–584. doi: http://doi.org/10.36074/grail-of-science.02.04.2021.118
  4. Hunt, R., Armstrong, D., Katelaris, P., Afihene, M., Bane, A., Bhatia, S. et. al. (2017). World Gastroenterology Organisation Global Guidelines. Journal of Clinical Gastroenterology, 51 (6), 467–478. doi: http://doi.org/10.1097/mcg.0000000000000854
  5. Gonzalez Ayerbe, J. I., Hauser, B., Salvatore, S., Vandenplas, Y. (2019). Diagnosis and Management of Gastroesophageal Reflux Disease in Infants and Children: from Guidelines to Clinical Practice. Pediatric Gastroenterology, Hepatology & Nutrition, 22 (2), 107–121. doi: http://doi.org/10.5223/pghn.2019.22.2.107
  6. Rybak, A., Pesce, M., Thapar, N., Borrelli, O. (2017). Gastro-Esophageal Reflux in Children. International Journal of Molecular Sciences, 18 (8), 1671. doi: http://doi.org/10.3390/ijms18081671
  7. Blaufox, A. D. (2018). Irregular heart rhythm (arrhythmias) in children. Waltham.
  8. Osteraas, N. (2021). Neurologic complications of brady-arrhythmias. Heart and Neurologic Disease. Elsevier, 163–174. doi: http://doi.org/10.1016/b978-0-12-819814-8.00006-8
  9. Lakshmanadoss, U. (Ed.). (2020). Differential Diagnosis of Chest Pain. BoD–Books on Demand. DOI: 10.5772/intechopen.7887
  10. Rees, C. J., Cantor, R. M., Pollack, Jr. C. V., Riese, V. G.; Pollack, Jr. C. (Ed.) (2019). Gastroesophageal Reflux Disease. Differential Diagnosis of Cardiopulmonary Disease. Cham: Springer, 441–449. doi: http://doi.org/10.1007/978-3-319-63895-9_30
  11. Romash, I. B., Mishchuk, V. G. (2020). The frequency of visceral and phenotypic markers in patients with the combination of undifferentiated connective tissue disease and gastroesophageal reflux disease. Wiadomości Lekarskie, 73 (7), 1492–1498. doi: http://doi.org/10.36740/wlek202007134
  12. Lukianenko, N. S., Petritsa, N. A., Kens, K. A. (2015). Place of undifferentiated connective tissue dysplasia in childhood pathology (literature review). Zdorove rebenka, 2, 80–85. Available at: http://nbuv.gov.ua/UJRN/Zd_2015_2_18
  13. Shodikulova, G. Z. (2017). Special features of clinical and functional disorders in patients with undifferentiated connective tissue dysplasia. European Science Review, 72–74. doi: http://doi.org/10.29013/esr-17-3.4-72-74
  14. Apenchenko, Yu. S., Basalaeva, N. V., Kapustina, L. V., Ivanova, I. I. (2014). Klinicheskie i biokhimicheskie priznaki displazii soedinitelnoy tkani u detey s gastroezofagealnoy reflyuksnoy boleznyu. Vestnik Ivanovskoy meditsinskoy akademii, 19 (3), 17–19.
  15. Nica, A. E., Alexa, L. M., Ionescu, A. O., Andronic, O., Păduraru, D. N. (2016). Esophageal disorders in mixed connective tissue diseases. Journal of medicine and life, 9 (2), 141.
  16. Shnitkova, E. V., Sesorova, I. S., Terenteva, T. V., Mozhaeva, A. N. (2016). Phenotypic features and body signs connective tissue dysplasia in neonates with hypoxic-ischemic central nervous system. Mezhdunarodniy nauchno-issledovatelskiy zhurnal, 11-3 (53), 173–175. doi: http://doi.org/10.18454/IRJ.2016.53.195
  17. Yagoda, A. V., Novikova, M. V., Gladkikh, N. N. (2015). Faktory riska prognosticheski znachimykh narusheniy serdechnogo ritma pri displazii soedinitelnoy tkani. Arkhiv vnutrenney meditsiny, 1, 60–63.

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Published

2021-07-30

How to Cite

Herasymova, O., & Filonova, T. (2021). Undifferentiated connective tissue dysplasia as a predictor of heart rate disorders in combination with gastroesophageal reflux disease in children . ScienceRise: Medical Science, (4(43), 41–45. https://doi.org/10.15587/2519-4798.2021.238132

Issue

No. 4(43) (2021)

Section

Medical Science

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Copyright (c) 2021 Oksana Herasymova, Tetiana Filonova

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