Clinical significance of calcium-sensing receptors in the development and course of recurrent wheezing and asthma in young children

Authors

DOI:

https://doi.org/10.15587/2519-4798.2023.295489

Keywords:

asthma, recurrent wheezing, calcium-sensing receptors, children

Abstract

The aim of the study: to evaluate the role of CaSR in the formation and course of recurrent wheezing and asthma in young children.

Materials and methods: a total of 70 patients participated in the study, including 20 children (8 boys and 12 girls) diagnosed with mild asthma, 30 patients (20 boys and 10 girls) with recurrent wheezing, and 20 relatively healthy children. The level of CaSR protein in the peripheral blood was measured twice: in the first 2 days of clinical manifestations and in remission. The levels of blood calcium (Ca), phosphorus (P), vitamin D (25(OH) D3) and indicators of cellular, phagocytic and humoral immunity were also studied. The level of CaSR in the blood serum was analyzed by ELISA using commercial kits (CaSR ELISA Kit Human E-EL-H0621, Elabscience, USA, protocol No. 2301070). Statistical processing was performed using StatSoft STATISTICA version 8.0 (Tulsa, Oklahoma) and MedCalc statistical software version 17.2.

Results: the lowest levels of CaSR protein were found in the group of children with asthma both during exacerbation and remission, which is associated with its redistribution from peripheral blood to smooth muscle. The level of CaSR protein in the group with recurrent wheezing did not differ during exacerbation and remission, which may be due to the low severity of the obstructive component of this group and the number of obstructions, which, in turn, does not lead to an obvious redistribution of this indicator to the smooth muscle of the bronchi. The level of CaSR protein is obviously the lowest in young children, which is confirmed by correlations. The available correlations with blood electrolytes and IgE confirm the involvement of CaSR protein in phosphorus-calcium metabolism and the development of the inflammatory process of allergic genesis.

Conclusions: level of CaSR protein in the serum of children depends on the number of obstructions, their course and severity of the disease. CaSR protein is directly involved in calcium-phosphorus metabolism

Author Biographies

Viktoriia Kolisnyk, Kharkiv National Medical University

Postgraduate Student

Department of Pediatrics No. 2

Yuriy Odynets, Kharkiv National Medical University

Doctor of Medical Sciences, Professor

Department of Pediatrics No. 2

References

  1. Al-Shamrani, A., Bagais, K., Alenazi, A., Alqwaiee, M., Al-Harbi, A. S. (2019). Wheezing in children: Approaches to diagnosis and management. International Journal of Pediatrics and Adolescent Medicine, 6 (2), 68–73. doi: https://doi.org/10.1016/j.ijpam.2019.02.003
  2. Tenevo, L., Piazza, M., Piacentini, G. (2016). Recurrent wheezing in children. Translational Pediatrics, 5 (1), 31–36. doi: https://doi.org/10.3978/j.issn.2224-4336.2015.12.01
  3. Zhai, J., Zou, Y., Liu, J., Jin, X., Ma, C., Li, J., Guo, R., Huang, B. (2019). Analysis of the predicting factors of recurrent wheezing in infants. Italian Journal of Pediatrics, 45 (1). doi: https://doi.org/10.1186/s13052-019-0609-y
  4. Padem, N., Glick Robison, R. (2019). The infant and toddler with wheezing. Allergy and Asthma Proceedings, 40 (6), 393–395. doi: https://doi.org/10.2500/aap.2019.40.4255
  5. Gillis, R. M. E., van Litsenburg, W., van Balkom, R. H., Muris, J. W., Smeenk, F. W. (2017). The contribution of an asthma diagnostic consultation service in obtaining an accurate asthma diagnosis for primary care patients: results of a real-life study. Npj Primary Care Respiratory Medicine, 27 (1). doi: https://doi.org/10.1038/s41533-017-0027-9
  6. José, B. P. de S., Camargos, P. A. M., Cruz Filho, Á. A. S. da, Corrêa, R. de A. (2014). Diagnostic accuracy of respiratory diseases in primary health units. Revista Da Associação Médica Brasileira, 60 (6), 599–612. doi: https://doi.org/10.1590/1806-9282.60.06.021
  7. Hoch, H. E., Houin, P. R., Stillwell, P. C. (2019). Asthma in Children: A Brief Review for Primary Care Providers. Pediatric Annals, 48 (3), 103–109. doi: https://doi.org/10.3928/19382359-20190219-01
  8. Pertseva, T. O. (2016). Trudnoshchi dyferentsiinoi diahnostyky pry bronkhialnii astmi. Zdorovia Ukrainy, 3 (34), 24–26.
  9. Bakirtas, A. (2017). Diagnostic challenges of childhood asthma. Current Opinion in Pulmonary Medicine, 23 (1), 27–33. doi: https://doi.org/10.1097/mcp.0000000000000338
  10. Matvienko, Yu. O., Yanovskoho, F. H. (2012). The features of immunogramma in patients with bronchial asthma and their practical implication. Astma ta alerhiia, 1, 51–56.
  11. Ruzanova, E. V. (2009). Porushennia kaltsii-fosfornoho metabolizmu i yoho korektsiia u ditei iz retsydyvuiuchym bronkhitom. Odesa.
  12. Bolbot, Yu. K., Hodiatska, K. K., Bordii, T. A. (2018). The importance of vitamin D deficiency in the formation of recurrent episodes of broncho-obstructive syndrome in young children. Problemy klinichnoi pediatrii, 1 (39), 17–27.
  13. Hall, S. C., Fischer, K. D., Agrawal, D. K. (2015). The impact of vitamin D on asthmatic human airway smooth muscle. Expert Review of Respiratory Medicine, 10 (2), 127–135. doi: https://doi.org/10.1586/17476348.2016.1128326
  14. Carroll, K. N., Gebretsadik, T., Larkin, E. K., Dupont, W. D., Liu, Z., Van Driest, S., Hartert, T. V. (2011). Relationship of maternal vitamin D level with maternal and infant respiratory disease. American Journal of Obstetrics and Gynecology, 205 (3), 215.e1–215.e7. doi: https://doi.org/10.1016/j.ajog.2011.04.002
  15. Ogeyingbo, O. D., Ahmed, R., Gyawali, M., Venkatesan, N., Bhandari, R., Botleroo, R. A. et al. (2021). The Relationship Between Vitamin D and Asthma Exacerbation. Cureus, 13 (8), e17279. doi: https://doi.org/10.7759/cureus.17279
  16. Yarova, P. L., Stewart, A. L., Sathish, V., Britt, R. D., Thompson, M. A., P. Lowe, A. P. et al. (2015). Calcium-sensing receptor antagonists abrogate airway hyperresponsiveness and inflammation in allergic asthma. Science Translational Medicine, 7 (284). doi: https://doi.org/10.1126/scitranslmed.aaa0282
  17. Xiang, Z., & Tao, D. (2022). The role of calcium‐sensitive receptor in ovalbumin‐induced airway inflammation and hyperresponsiveness in juvenile mice with asthma. The Kaohsiung Journal of Medical Sciences, 38 (12), 1203–1212. doi: https://doi.org/10.1002/kjm2.12601
  18. Roesler, A. M., Wicher, S. A., Ravix, J., Britt, R. D., Manlove, L., Teske, J. J. et al. (2019). Calcium sensing receptor in developing human airway smooth muscle. Journal of Cellular Physiology, 234 (8), 14187–14197. doi: https://doi.org/10.1002/jcp.28115
  19. Wen, T., Wang, Z., Chen, X., Ren, Y., Lu, X., Xing, Y. et al. (2021). Structural basis for activation and allosteric modulation of full-length calcium-sensing receptor. Science Advances, 7 (23). doi: https://doi.org/10.1126/sciadv.abg1483
  20. Centeno, P. P., Binmahfouz, L. S., Alghamdi, K., Ward, D. T. (2023). Inhibition of the calcium-sensing receptor by extracellular phosphate ions and by intracellular phosphorylation. Frontiers in Physiology, 14. doi: https://doi.org/10.3389/fphys.2023.1154374
Clinical significance of calcium-sensing receptors in the development and course of recurrent wheezing and asthma in young children

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Published

2023-09-30

How to Cite

Kolisnyk, V., & Odynets, Y. (2023). Clinical significance of calcium-sensing receptors in the development and course of recurrent wheezing and asthma in young children. ScienceRise: Medical Science, (5(56), 29–35. https://doi.org/10.15587/2519-4798.2023.295489

Issue

No. 5(56) (2023)

Section

Medical Science

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Copyright (c) 2023 Viktoriia Kolisnyk, Yuriy Odynets

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