Effect of vacuum therapy on reparative tissue regeneration in wound area
DOI:
https://doi.org/10.15587/2519-4798.2016.72045Keywords:
purulent surgical infection, vacuum therapy, tissues reparative regeneration, proliferative indexAbstract
Aim of research was to study the influence of a low-dose vacuum therapy, as the most effective method for local wound treatment, on reparative tissue regeneration, compared with the traditional treatment methods. The object of research was patients with purulent surgical diseases of soft tissues. The subject of study was changes in dynamics of tissues proliferative activity.
Methods: the control group consisted of patients with purulent surgical diseases (16 patients), being examined comprehensively and treated by the traditional scheme. The main group consisted of patients with purulent surgical diseases (16 patients), in which a low-dose vacuum therapy method was used for local wound treatment.
Results. The obtained results show high reparative effect of a low-dose vacuum on wound area tissues, due to proliferative processes activation in wound. The effect of the negative pressure on wound area tissues leads to increasing the amount of cells in high proliferative activity, which activates reparative processes in wound defect area.
Conclusion. The use of immunohistochemistry method for determination of the reparative regeneration level in tissues at KI 67 antigen expression study allows evaluating objectively the level of proliferative activity and give guidelines for wound closure this or that way
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Copyright (c) 2016 Алексей Николаевич Велигоцкий, Роман Владимирович Савицкий, Алексей Николаевич Довженко
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